ALENDRONATE-INDUCED RESPIRATORY DISTRESS

PRAVALIKA M; SRIVANI V; SAGAR PAMU

doi:10.22159/ajpcr.2020.v13i7.37811

Authors

PRAVALIKA M Department of Pharmaceutical Analysis, Geethanjali College of Pharmacy, Hyderabad, Telangana, India. http://orcid.org/0000-0003-0518-3742
SRIVANI V Department of Pharmaceutical Analysis, Geethanjali College of Pharmacy, Hyderabad, Telangana, India.
SAGAR PAMU Department of Pharmacy Practice, Guru Nanak Institutions Technical Campus - School of Pharmacy, Ibrahimpatnam, Ranga Reddy, Hyderabad, Telangana, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i7.37811

Keywords:

Alendronate, Respiratory distress, Dyspnoea, Wheezing, Allergic bronchopulmonary aspergillosis, Basophilia, Elevated immunoglobulin E

Abstract

Respiratory distress is a rare adverse effect of alendronate that is typically associated with severe dyspnoea and wheezing and typically requires hospitalization. The patient with a history of dyspnoea and wheezing during the strenuous workload was treated promptly with alendronate for newly diagnosed osteoporosis. After 2 days, respiratory distress complications were restarted and we accurately reported the patient with basophilia, elevated immunoglobulin E (with a blood test), and allergic bronchopulmonary aspergillosis (with computed tomography scan image). The prospective patient was adequately understood as alendronate-induced respiratory distress with an unfortunate rechallenge method. Although there is no direct causal relationship from this adverse case report, the possible mechanism has discussed typically based on peer-reviewed literature.

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