EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ROSCOE (GINGER) ON ACUTE AND CHRONIC INFLAMMATION IN ADULT ALBINO RATS

Authors

  • Nagaraj B Malipatil Private Practice
  • Manjunath S
  • Shruthi Dp

Abstract

 

Objective: Zingiber officinale (ZO) Roscoe (Ginger) is known to have many medicinal properties. The present study was carried out to evaluate the
anti-inflammatory activity of aqueous extract of ginger in adult albino rats, both in acute and chronic inflammatory settings and to compare the same
with standard anti-inflammatory agent diclofenac sodium.
Methods: Anti-inflammatory activity of ginger at the dose of 500 mg/kg body weight administered orally was evaluated in adult albino rats divided
into different groups as control, test and standard. Effect of ginger on acute inflammation was evaluated by carrageenan in induced rat paw edema
method and chronic inflammation was evaluated by rexin pellet granuloma method. Histopathological analysis was also done to evaluate effect of
ginger on leukocyte migration and lymphocyte accumulation at the site of acute and chronic inflammation respectively.
Results: Aqueous extract of ginger decreased the signs of both acute and chronic inflammation. The percent inhibition of edema (for acute
inflammation) with ZO extract was 28.80%, whereas with diclofenac sodium 63.46%. Percentage inhibition of granulation tissue (for chronic
inflammation) for ginger was 31.04% and 63.42% for diclofenac sodium.
Conclusion: Aqueous extract of ginger decreased the signs of both acute and chronic inflammation and was comparable to standard anti-inflammatory
drug diclofenac sodium. As currently available anti-inflammatory drugs are associated with number of side-effects, ginger can be potentially explored
as an anti-inflammatory agent with minimal or no side-effects.

Keywords: Zingiber officinale Roscoe, Ginger, Acute inflammation, Chronic inflammation, Rat paw oedema, Rexin pellet granuloma, Diclofenac sodium.

Downloads

Download data is not yet available.

References

Nadkarni AK. Dr. KM Nadkarni’s Indian Materia Medica. 3rd ed., Vol. I. Panvel: Dhootapapeshwar Prakashan Ltd.; 1927. p. 1309.

Available from: http://www.plants.usda.gov/java/profile?symbol=210F. [Last accessed on 2011 Jul 18].

Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr 2006;96(4):660-6.

Penna SC, Medeiros MV, Aimbire FS, Faria-Neto HC, Sertié JA, Lopes-Martins RA. Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine 2003;10:381-5.

Baskar V, Selvakumar K, Madhan R, Srinivasan G, Muralidharan M. Study on improving bioavailability ratio of anti-inflammatory compound from ginger through nano transdermal delivery. Asian J Pharm Clin Res 2012;5(3):241-6.

Ahmed RS, Seth V, Banerjee BD. Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: Comparison with ascorbic acid. Indian J Exp Biol 2000;38(6):604-6.

Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res 2006;20(9):764-72.

Penna SC, Medeiros MV, Aimbire FS, Faria-Neto HC, Sertie JA, Lopes-Martins RA. Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes in rat paw and skin oedema; phytomedicine 2003;10:381-5.

Sharma SS, Kochupillai V, Gupta SK, Seth SD, Gupta YK. Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in dogs. J Ethnopharmacol 1997;57(2):93-6.

Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids 2002;67(6):475-8.

Shukla Y, Singh M. Cancer preventive properties of ginger: A brief review. Food Chem Toxicol 2007;45(5):683-90.

Jagetia G, Baliga M, Venkatesh P. Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: Mechanism of action. Cancer Biother Radiopharm 2004;19(4):422-35.

Ficker CE, Arnason JT, Vindas PS, Alvarez LP, Akpagana K, Gbéassor M, et al. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses 2003;46(1-2):29-37.

Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 2008;46(2):409-20.

Wang WH, Wang ZM. Studies of commonly used traditional medicine-ginger. Zhongguo Zhong Yao Za Zhi 2005;30(20):1569-73.

Surh YJ, Park KK, Chun KS, Lee LJ, Lee E, Lee SS. Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. J Environ Pathol Toxicol Oncol 1999;18(2):131-9.

Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo) 1992;40(2):387-91.

Ghosh MN. Toxicity studies. Fundamentals of Experimental Pharmacology. 4th ed. Calcutta: Hilton and Company; 2008. p. 178.

Laurence DR, Bacharach AL. Evaluation of Drug Activities: Pharmacometrics. Vol. 2. London: Academic Press; 1964. p. 873.

Finney RS, Somers GF. The antiinflammatory activity of glycyrrhetinic acid and derivatives. J Pharm Pharmacol 1958;10(10):613-20.

Kumar VS, Dwajani S, Gurjar D, Patil U, Vinodkumar CS. Effect of rosuvastatin as an anti-inflammatory agent in albino rats. Asian J Pharm Clin Res 2011;4 Suppl 2:74-6.

Published

01-03-2015

How to Cite

Malipatil, N. B., M. S, and S. Dp. “EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ROSCOE (GINGER) ON ACUTE AND CHRONIC INFLAMMATION IN ADULT ALBINO RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 2, Mar. 2015, pp. 113-6, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/3968.

Issue

Section

Original Article(s)