EVALUATING RISK FACTORS, CLINICAL AND THERAPEUTIC PROFILE OF STROKE PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL

LAKSHMI P; SUCHITHA S; SAI ASWANI V; DHANYA SREE V; ZAFEER SK

doi:10.22159/ajpcr.2021.v14i2.40243

Authors

LAKSHMI P Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati.
SUCHITHA S Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati.
SAI ASWANI V Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati.
DHANYA SREE V Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati.
ZAFEER SK Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i2.40243

Keywords:

Prescribing patterns, Risk factors, Stroke

Abstract

Objective: According to the World Health Organization, stroke is the second leading cause of death for people above the age of 60 years, and the fifth leading cause in people aged 15–59 years old. This study mainly aims to evaluate the prevalence of risk factors, clinical features, pattern of drugs prescribed, and severity of stroke among patients.

Methods: A cross-sectional study was carried out in a tertiary care teaching hospital on 210 patients for a period of 6 months. Patients aged 18 years and above were included in the study. The severity of stroke was assessed using National Institute of Health Stroke Scale (NIHSS).

Results: The majority of the patients were under the age group of 61–70 years (31%). The incidence of ischemic stroke (81%) was more common compared to hemorrhagic stroke (19%). Males (66%) are prone to stroke compared to females (34%). The most common risk factor was hyperlipidemia (29%) followed by hypertension (17%). Antihypertensives (28%) were most commonly used drugs followed by antihyperlipidemics (23%). Most of the prescriptions were prescribed with 4–6 drugs per prescription (62%). Moderate stroke (69%) was most commonly observed in patients. A total of 147 drug-drug interactions were observed. Among 147 drug-drug interaction, the most commonly observed drug-drug interaction was aspirin with metformin (15%).

Conclusion: The present study emphasizes on the need to identify risk factors and providing awareness among the patients by a pharmacist in minimizing the disease burden. Early identification of risk factors and pattern of therapy based on therapeutic guidelines plays a crucial role in qualitative patient care.

Downloads

Download data is not yet available.

References

Smith WS, Kasper DL. Harrison’s Principles of Internal Medicine. 19th ed. New York: McGraw-Hill Medical Publishing Division; 2015.

Chandrashekar G, Reddy H. Etiology and risk factors of stroke in young: A prospective study. Int J Sci Study 2016;4:79-83.

Kuriakose C, Shifafiya MN, Tharakan NS, Sattanathan K, Kumar S. A prospective study of clinical profile of stroke in a tertiary care hospital. Asian J Pharm Clin Res 2016;9:178-81.

Kumar NS, Padala R, Vallampalli G, Thatikonda A, Prasad PN. Clinical and Etiological profile of ischemic stroke in young adults: A prospective, observational, hospital based study from seacoast population of South India. Austin J Cerebrovasc Dis Stroke 2017;4:1-4.

Kumar P, Devi P, Athmika N. A retrospective study of clinical profile of stroke victims in Coimbatore medical college hospital. IOSR J Dent Med Sci 2016;15:67-70.

Chanu KJ, Patrick SR, Marak S, Devi B. A study on risk factors of stroke. IOSR J Dent Med Sci 2017;16:35-40.

Innes JA, Maxwell S. Davidson’s Essentials of Medicine. 2nd ed. New York: Elsevier; 2016.

Jadhav YL, Bondarde SA. Study of risk factors and clinical profile of stroke in young adults. MVP J Med Sci 2015;2:15-9.

DiPiro JT, Talber Rl, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy A Pathophysiologic Approach. 7th ed. New York: McGraw-Hill; 2005.

Tomar AP, Ramteke SK, Singh R, Ramteke S. Study of risk factors and clinical profile of acute stroke. J Evol Med Dent Sci 2014;3:5688-94.

Available from: https://www.saebo.com/blog/nih-stroke-scale-nihss.

Pasha SA, Bhuvana CH, Kumudini V, Haribabu R, Arif Pasha SK, Bhaskara Rao B. Drug utilization patterns of stroke patients in a tertiary care teaching hospital. World J Pharm Res 2017;6:997-1005.

Himaja J, Rakesh B. A study of clinical profile, risk factors and drug utilization pattern in cerebrovascular stroke. Eur J Biomed Pharm Sci 2017;4:258-73.

Patne SV, Chintale KN. Study of clinical profile of stroke patients in rural tertiary health care centre. Int J Adv Med 2016;3:666-70.

Vaidya CV, Majmudar DK. A retrospective study of clinical profile of stroke patients from GMERS medical college and hospital, Gandhinagar, Gujarat. Int J Clin Trials 2014;1:62-6.

Konduru SS, Ranjan A, Nallajerla JS, Gonuguntala S. Study of symptoms, risk factors and prescribing patterns in cerebral stroke patients. Indian J Pharm Pract 2017;10:20-5.

Raghuvanshi S. A study of clinical profile and subtypes of acute ischemic stroke in a tertiary care center. Int J Sci Study 2014;4:128-30.

Singh S, Swetha K. A retrospective study of prescription pattern of drugs in the management of stroke, at BRIMS teaching hospital, Bidar, India. Int J Basic Clin Pharmacol 2018;7:1929-33.

Vurumadla S, Rakshith V, Murari CH, Venkateshwarlu K. A study on symptoms, risk factors and prescribing pattern of drugs used in stroke patients. Int J Pharm Pharm Sci 2015;7:421-6.

Isaac BS, Bharathi DR, Priyanka N, John J. A study on management of stroke in a tertiary care hospital. Int J Sci Res Multidiscip Stud 2019;5:26-41.

Abbasi MY, Ali A. Prescribing pattern of drugs in stroke patients: A prospective study. Arch Pharm Pract 2012;3:283-8.

Jena SS, Jena M, Mishra S, Meher BR. Utilization pattern of different drugs in different types of stroke in a tertiary care teaching hospital. Int J Pharm Sci Rev Res 2018;49:85-90.

Sah B, Bhandari S, Yadav A, Yadav S, Dharshini NM, Mahadevamma L, et al. A prospective study on prescribing patterns of antiplatelet drugs. World J Pharm Pharm Sci 2018;7:1668-711.