PRESCRIBING TRENDS IN ASTHMA IN PEDIATRICS: A LONGITUDINAL, OBSERVATIONAL STUDY
DOI:
https://doi.org/10.22159/ajpcr.2021.v14i5.40894Keywords:
Pediatrics, Asthma, PrescriptionAbstract
Objectives: In recent years, the prevalence of asthma has globally increased. Despite intensive treatment, many children with asthma are not achieving good symptom control. The present study aims to analyze the prescribing trends in pediatric asthma according to the World Health Organization (WHO) prescribing indicators.
Methods: This was an observational, longitudinal study conducted for the duration of 6 months with a sample size of 62. Children with age 1–14 years with asthma, who fulfilled the inclusion criteria, were enrolled after obtaining the written informed consent. Data were collected from outpatient department prescription slips for 2 times, one at 1st enrollment and the next after 1 month and changes in the prescription were noted. Peak expiratory flow rate (PEFR) was measured on both visits and the change in PEFR was noted.
Results: Male predominance was seen (67.74%) with age of 5–9 years (40.32%). Average number of drugs per prescription was 1.96. The most commonly prescribed anti-asthmatic drug was inhaled corticosteroids (ICS) (78.22%). Only 1.5% drugs were prescribed by generic names and 22.22% drugs from the essential drug list. Inhalational route (38.71%) was preferred over the oral route (20.97%). After 1 month of treatment, change in PEFR was found to be statistically significant.
Conclusion: The study concluded that average number of drugs per prescription and use of antibiotics was conforming to the WHO prescribing standards but prescribing from essential medicines list and by generic name need to be encouraged.
Downloads
References
Ferrante G, La Grutta S. The burden of pediatric asthma. Front Pediatr 2018;6:186.
Sharma HL, Sharma KK. Principles of Pharmacology. 3rd ed. New Delhi: Paras Medical Publisher; 2017.
The Global Asthma Report, Auckland, New Zealand; 2018. Available from: http://www.globalasthmareport.org. [Last assessed on 2021 Feb 25].
Kleigman RM, Jeme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, et al. Nelson Textbook of Paediatrics. In: Liu AH, Spahn JD, Sicherer SH, editors. Childhood Asthma. 21st ed. Canada: Elsevier; 2019. p. 4945-9.
Burbank AJ, Sood AK, Kesic MJ, Peden DB, Hernandez ML. Environmental determinants of allergy and asthma in early life. J Allergy Clin Immunol 2017;140:1-12.
Gupta A, Bhat G, Pianosi P. What is new in the management of childhood asthma? Indian J Pediatr 2018;85:773-81.
Klok T, Kaptein AA, Brand PL. Non-adherence in children with asthma reviewed: The need for improvement of asthma care and medical education. Pediatr Allergy Immunol 2015;26:197-205.
Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep 2017;17:19.
Schatz M, Camargo CA Jr. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann Allergy Asthma Immunol 2003;91:553-8.
Kamfar HZ, Koshak EE. The impact of some demographic factors on the severity of asthma in children. J Family Community Med 2002;9:19-24.
Gupta S, Awasthi S. Assessment of treatment pattern of childhood asthma reporting to outpatient’s facility in a tertiary care hospital in Lucknow, North India: A cross-sectional study. Clin Epidemiol Glob 2016;6-11.
Shah RD, Burute SR, Ramanand SJ, Murthy MB, Shah ND, Kumbhar AV. Drug utilization study in patients with bronchial asthma of a tertiary care hospital in Western Maharashtra. Indian J Allergy Asthma Immunol 2019;33:105-11.
Friedman HS, Eid NS, Crespi S, Wilcox TK, Reardon G. Retrospective claims study of fluticasone propionate/salmeterol fixed-dose combination use as initial asthma controller therapy in children despite guideline recommendations. Clin Ther 2009;31:1056-63.
Thomas M, Murray-Thomas T, Fan T, Williams T, Taylor S. Prescribing patterns of asthma controller therapy for children in UK primary care: A cross-sectional observational study. BMC Pulm Med 2010;10:29.
Pandey A, Tripathi P, Pandey RD. Prescription pattern in asthma therapy at Gorakhpur hospitals. Lung India 2010;27:8-10.
Prasad A, Pradhan SP, Datta PP, Samajdar SS, Panda P. Drug prescription pattern for bronchial asthma in a tertiary-care hospital in Eastern India. Natl J Physiol Pharm Pharmacol 2015;5:263-6.
Srivastava R, Sharma S, Keshri L, Wal P. Assessment of prescription pattern in asthma therapy at Shamli hospitals. Rev Recent Clin Trials 2012;7:158-64.
World Health Organization. Introduction to Drug Utilization Research. Geneva: World Health Organization; 2003. Available from: https:// www.apps.who.int/medicinedocs/pdf/s4876e/s4876e.pdf.
International Network for Rational Use of Drugs. The Development of Standard Values for the WHO Drug Use Prescribing Indicators. Geneva: World Health Organization; 2004. Available from: http://www. archives.who.int/prduc2004/rducd/ICIUM_Posters/1a2_txt.htm.
Michael B, James N, Sreena S, Sindhuja K, Nanjwade BK. Drug utilization evaluation of bronchial asthma in tertiary care hospital. World J Pharm Pharm Sci 2016;5:1075-91.
Aleemuddin NM, Bahmed F, Bashir MS, Ali A, Khatoon S, Hussain MM, et al. A cross-sectional study on prescribing patterns on patients suffering from respiratory disorders in a teaching hospital of South India. J Contemp Med Dent 2014;2:12-7.
Olurishe CO, Mohammed M. Evaluation of steroid utilization in management of asthma in a tertiary hospital in Northern Nigeria. Afr J Pharmacol Ther 2015;4:33-9.
Lovinsky S, Rastogi D. Prescription habits for preventative medications among pediatric emergency department physicians at an inner-city teaching hospital. J Asthma 2010;47:1011-4.
Shiyas KP, Gopi M. Factors affecting peak expiratory flow rates in children of 9-12 years of age. Int J Pediatr Res 2017;4:651-56.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.