ANALYTICAL APPLICATIONS OF MEFENAMIC ACID BY HYDROTROPE APPROACH: TITRIMETRIC ESTIMATION AND ULTRAVIOLET METHOD VALIDATION

DEVIKA TRIPATHI; DINESH KUMAR SHARMA; JAGANNATH SAHOO

doi:10.22159/ajpcr.2021.v14i7.41682

Authors

DEVIKA TRIPATHI Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, India.
DINESH KUMAR SHARMA Department of Pharmacy, Himalayan Institute of Pharmacy, Dehradun, Uttarakhand, India.
JAGANNATH SAHOO Department of Pharmacy, School of Pharmaceutical and Population Health Informatics, Dehradun Institute of Technology University, Dehradun, Uttarakhand, India.

DOI:

https://doi.org/10.22159/ajpcr.2021.v14i7.41682

Keywords:

Hydrotropy, Solubility enhancement, Titrimetric analysis, Ultraviolet method, Development, Validation, Mefenamic acid, Sodium benzoate

Abstract

Objectives: Mefenamic acid is used as a modal nonsteroidal anti-inflammatory drug for analytical estimation. Due to the poor aqueous solubility, mefenamic acid liberated reduced bioavailability.

Methods: The hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. Experimentally, 2 M sodium benzoate has been employed in the prior titrimetric estimation of mefenamic acid and shows synergistic enhancement in the solubility of mefenamic acid by many folds as compared to the distilled water. Similarly, sodium benzoate approach was further applied in analytical estimation of marketed oral dosage forms in tablets, capsules, and suspension for checking the reproducibility of applied approach by ultraviolet (UV) method. Validation of UV method was further done and checked for linearity, accuracy, and precision. Drug degradation studies were also performed successfully to investigate the sustainability of mefenamic acid in various dosage forms under various stress conditions and to establish the preferred storage conditions for the drug.

Results: In the present experimental investigation, obtained mean % recoveries were close to 100 indicating the accuracy of the proposed approach. Similarly, in analytical estimation of mefenamic acid in oral marketed forms, results have reported lower values of standard deviation, % coefficient of variation, and standard error facilitated the reproducibility and precision of the proposed approach in the titrimetric estimation and analytical validation of UV method mefenamic acid in bulk and marketed forms.

Conclusion: Therefore, a new, simple, precise, and inexpensive proposed method was executed by validating the result statistically.

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