CLINICOPATHOLOGICAL STUDY OF OVARIAN NEOPLASMS – AN INSTITUTIONAL PERSPECTIVE

Authors

  • VASUNDARA GARDAS Department of Pathology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.
  • PRASANTHI CHERUKURI Department of Pathology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.
  • SUMERA SALOMI Department of Physiology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i1.43429

Keywords:

Ovarian neoplasm, Benign borderline, Malignant

Abstract

Objective: The objective of the study was to know the frequency and histomorphological patterns of ovarian neoplasms concerning age.

Methods: A 2-year retrospective study was done in the pathology department, GITAM Institute of Medical Sciences and Research. Data were retrieved from laboratory records, H & E slides of ovarian biopsies of diagnosed neoplasms were screened.

Results: During the study period, 70 ovarian neoplasms were reported. Ovarian tumors were categorized according to the WHO classification. In this study surface, epithelial tumors were most common at 87.14% followed by germ cell tumors at 11.42% and sex cord-stromal tumors at 1.42%. Serous cystadenoma was the most common benign surface epithelial tumor.

Conclusion: Histopathology is the gold standard for diagnosing ovarian neoplasms. Newer diagnostic techniques such as immunohistochemistry and morphometric analysis help decide management and prognosis.

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References

Parkin DM. The evolution of the population-based cancer registry. Nat Rev Cancer 2006;6:603-12.

Modan B, Hartge P, Hirsh-Yechezkel G, Chetrit A, Lubin F, Beller U, et al. Parity, oral contraceptives, and the risk of ovarian cancer among carriers and non-carriers of a BRCA1 or BRCA2 mutation. N Engl J Med 2001;345:235-40.

Kurian AW, Balise RR, McGuire V, Whittemore AS. Histologic types of epithelial ovarian cancer: Have they different risk factors? Gynecol Oncol 2005;96:520-30.

Zhou B, Sun Q, Cong R, Gu H, Tang N, Yang L, et al. Hormone replacement therapy and ovarian cancer risk: A meta-analysis. Gynecol Oncol 2008;108:641-51.

Smith LH, Morris CR, Yasmeen S, Parikh-Patel A, Cress RD, Romano PS. Ovarian cancer: Can we make the clinical diagnosis earlier. Cancer 2005;104:1398-407.

Goff BA, Mandel L, Muntz HG, Melancon CH. Ovarian carcinoma diagnosis. Cancer 2000;89:2068-75.

Bell DA, Weinstock MA, Scully RE. Peritoneal implants of ovarian serous borderline tumors. Histologic features and prognosis. Cancer 1988;62:2212-22.

Akeson M, Jakobsen AM, Zetterqvist BM. A population-based 5-year cohort study including all epithelial ovarian cancer cases in western Sweden: 10-year survival and prognostic factors. Int J Gynecol Cancer 2009;19:116-23.

Barlin JN, Jelinic P, Olvera N, Bogomolniy F, Bisogna M, Dao F, et al. Validated gene targets associated with curatively treated advanced serous ovarian carcinoma. Gynecol Oncol 2013;128:512-7.

Suidan RS, Ramirez PT, Sarasohn DM, Teicher JB, Mironov S, Iyer RB, et al. A multicenter prospective trial evaluates the ability of preoperative computed tomography scan and serum CA-125 to predict suboptimal cytoreduction at primary debulking surgery for advanced ovarian, fallopian tube, and peritoneal cancer. Gynecol Oncol 2014;134:455-61.

Kurman RJ, Ellenson LH, Ronnett BM. Blaustein’s Pathology of the Female Genital Tract. 6th ed. USA: Springer; 2011.

Ranjana H, Sadhna S, Ekta P. Histopathological spectrum of ovarian tumors-a two-year retrospective study. Indian J Pathol Oncol 2017;4:450-3.

Prakash A, Chinthakindi S, Duraiswami R, Indira V. Histopathological study of ovarian lesions in a tertiary care center in Hyderabad, India: A retrospective five-year study. Int J Adv Med 2017;4:745-9.

Vinitha S, Shreya H, Zulfikar A, Umaru N. Histopathological study of malignant soft tissue tumors. J Evol Med Den Sci 2015;14:3320-8.

Garg N, Anand AS, Annigeri C. Study of histomorphological spectrum of ovarian tumors. Int J Med Health Res 2017;3:12-20.

Hardik HM, Maru A, Lakum N, Ashok A, Naresh T, Jayesh J. Relative frequency and histopathological pattern of ovarian masses. Int J Med Sci Public Health 2014;3:81-4.

Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumors: A study of 282 cases. J Indian Med Assoc 2002;100:420, 423-4, 447.

Manoja V, Pramod M, Jyothi V, Chandrashekar KP. Clinicopathological study of ovarian tumors: A 2-year study. Int J Sci Stud 2017;5:300-5.

Mankar DV, Jain GK. Histopathological profile of ovarian tumors: A twelve-year institutional experience. Muller J Med Sci Res 2015;6:107-11.

Garg N, Anand AS, Annigeri C. Study of the histomorphological spectrum of ovarian tumors. Int J Med Health Res 2017;3:12-20.

Kanpurwala SH, Chavan SM, Agrawal S. A study of clinicomorphological profile of ovarian tumours in Western India. J Med Sci Clin Res 2016;4:15040-7.

Modepalli N, Venugopal SB. Clinicopathological study of surface epithelial tumours of the ovary: An institutional study. J Clin Diagn Res 2016;10:EC01-4.

Patil RK, Bhandari BJ, Kittur SK, Haravi RM, Aruna S, Jadhav MN. Histomorphological study of ovarian tumours at a tertiary care centre. Ann Pathol Lab Med 2017;4:638-45.

Sanjeev N, Anjali S, Shrikant N, Rahul K. Spectrum of ovarian tumours-a five year study. J Pathol Nepal 2017;7:1180-3.

Malli M, Vyas B, Gupta S, Desai H. A histological study of ovarian tumours in different age groups. Int J Med Sci Public Health 2014;3:338-41.

Published

07-01-2022

How to Cite

GARDAS, V., P. CHERUKURI, and S. SALOMI. “CLINICOPATHOLOGICAL STUDY OF OVARIAN NEOPLASMS – AN INSTITUTIONAL PERSPECTIVE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 1, Jan. 2022, pp. 72-76, doi:10.22159/ajpcr.2022.v15i1.43429.

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