TO STUDY THE SERUM LIPID PROFILE IN ISCHEMIC AND HEMORRHAGIC STROKE AMONG THE PATIENTS IN TERTIARY HEALTH CENTRE

ANKUR CHHARI; KHANNA V N; RAHUL JAIN; VISHNU PAL

doi:10.22159/ajpcr.2022.v15i2.43732

Authors

ANKUR CHHARI Department of Medicine, PCMS and RC, Bhopal, Madhya Pradesh, India.
KHANNA V N Department of Medicine, PCMS and RC, Bhopal, Madhya Pradesh, India.
RAHUL JAIN Department of Medicine, PCMS and RC, Bhopal, Madhya Pradesh, India.
VISHNU PAL Department of Anatomy, PCMS and RC, Bhopal, Madhya Pradesh, India. https://orcid.org/0000-0002-3388-0273

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i2.43732

Keywords:

Stroke, Dyslipidemia, Correlation, Total cholesterol, HDL ratio

Abstract

Objectives: To assess, correlate and compare the levels of various parameters of lipid profile in patients with ischemic and hemorrhagic stroke.

Methods: The study was conducted as an observational study at the Department of Medicine, People’s Hospital on 100 patients presenting with focal neurological deficit, altered sensorium, or with CT/MRI findings suggestive of stroke during the study duration of 18 months. Based upon the type of stroke, patients were categorized into two groups, i.e. ischemic stroke and hemorrhagic stroke. NCEP-ATP III guidelines were used for estimation of dyslipidemia and association of dyslipidemia was observed with type of stroke.

Results: Of 100 cases, ischemic stroke was documented in 74% cases, whereas 26% of patients presented with hemorrhagic stroke. Two groups were comparable in terms of baseline characteristics (p>0.05). Mean total cholesterol levels and total cholesterol and total cholesterol to HDL ratio was significantly higher in ischemic stroke as compared to hemorrhagic stroke (p<0.05). However, mean serum HDL level was significantly lower in patients with ischemic stroke as compared to hemorrhagic stroke (p<0.05). Total cholesterol, and total cholesterol: HDL ratio showed statistically significantly negative correlation with type of stroke and positive correlation was noted between HDL and hemorrhagic stroke.

Conclusion: The prevalence of stroke is rising rapidly and the age of presentation of stroke is reducing. Ischemic stroke is the most common type of stroke whereas hemorrhagic stroke is less commonly observed in less than one-third of patients. Dyslipidemia is a significant risk factor for ischemic stroke. Raised Total cholesterol, and total cholesterol: HDL levels and lower HDL levels are independent predictors of ischemic stroke.

Downloads

Download data is not yet available.

Author Biography

VISHNU PAL, Department of Anatomy, PCMS and RC, Bhopal, Madhya Pradesh, India.

ANATOMY DEPARTMENT

ASSISTANT PROFESSOR

References

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al. An updated definition of stroke for the 21st century: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013;44:2064-89.

World Stroke Organization. WSO Global Stroke Fact Sheet. World Stroke Organization; 2020. Available from https://www.world-stroke. org/assets/downloads/WSO_Global_Stroke_Fact_Sheet.pdf [Last accessed on 2020 Oct 24].

Arboix A, Alió J. Cardioembolic stroke: Clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev 2010;6:150-61.

Adibhatla RM, Hatcher JF. Altered lipid metabolism in brain injury and disorders. Subcell Biochem 2008;49:241-68.

Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 1990;82:495-506.

Kirshner HS. Medical prevention of stroke. South Med J 2003;96:354-8.

Bhalla A, Gupta OP, Gupta SB. Predicting mortality in stroke. Neurol India 2002;50:279-81.

Eckel RH, Cornier MA. Update on the NCEP ATP-III emerging cardiometabolic risk factors. BMC Med 2014;12:115.

Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts. Lancet 1995;346:1647-53.

Grace MN, Shameer VK, Rajesh KR, Raghavan R, Sreejesh S. A prospective observational study on the clinical profile of ischemic stroke in a tertiary care centre in Thrissur, Kerala. Int J Med Res Rev 2016;4:1371-5.

Manorenj S, Siddiqui IA, Muralikrishna P, Anand K, Sagari N. Is low cholesterol a predisposing factor for primary intracerebral hemorrhage? A South Indian perspective. J Clin Diagn Res 2018;12:5.

Onwuegbuzie GA, Rifkatu SR. Serum lipid profile of patients with ischemic stroke in a tertiary centre in Nigeria. IOSR J Dent Med Sci 2016;15:60-4.

Togha M, Gheini MR, Ahmadi B, Khashaiar P, Razeghi S. Lipid profile in cerebrovascular accidents. Iran J Neurol 2011;10:1.

Shrivastav D, Singh AN, Kushwaha JS, Tripathi P, Verma MK,Saxena N. Diagnostic value of lipid profile in hemorrhagic stroke patients. Era J Med Res 2019;6:1-6.

Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF, et al. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag 2009;5:757.

Liu X, Yan L, Xue F. The associations of lipids and lipid ratios with stroke: A prospective cohort study. J Clin Hypertens 2019;21:127-35.

Zhang Y, Tuomilehto J, Jousilahti P, Wang Y, Antikainen R, Hu G. Total and high-density lipoprotein cholesterol and stroke risk. Stroke 2012;43:1768-74.