DESIGN, DEVELOPMENT AND EVALUATION OF FLUCONAZOLE TOPICAL GEL

Authors

  • Sudipta Das
  • Arnab Samanta
  • Ananya Bose

Abstract

 

Objective: The present study was designed to formulate and evaluate Fluconazole topical gel.
Methods: The gel was formulated by using polymer sodium carboxy methyl cellulose in different ratio. The drug-excipient compatibility studies were
confirmed by differential scanning calorimetry analysis. The evaluation of formulated fluconazole topical gel was carried out for physical appearance,
pH-value, spreadability, rheological behavior, drug content and in-vitro release study.
Results: The rheological behavior of the prepared gels showed a pseudo plastic flow, which is a good characteristic of topical pharmaceutical gels.
The formulated gel showed good physical characteristic and release profile. The release data was fitted into different kinetics equations by regression
analysis. Stability studies showed no significant change in physical appearance, rheological properties and drug release upon storage for 3 months at
ambient condition.
Conclusion: Fluconazole was successfully incorporated into the different topical gel formulations, and the developed formula could be very promising
topical alternative for the treatment of skin fungal infection.
Keywords: Fluconazole, Differential scanning calorimetry, Sodium carboxymethyl cellulose, Gel, Kinetic.

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References

Kaur LP, Guleri TK. Topical gel: A recent approach for novel drug delivery. Asian J Biomed Pharm Sci 2013;3(17):1-5.

Roychowdhury S, Singh DH, Gupta R, Masih D. A review on pharmaceutical gel. Int J Pharm Res Bio Sci 2012;1(5):21-36.

Alvarez-Lorenzo C, Concheiro A. Effects of surfactants on gel behavior: Design implications for drug delivery systems. Am J Drug Deliv 2001;1(2):77-101.

Tripathi KD. Essential of Medical Pharmacology. 5th ed. New Delhi: Jaypee Brothers; 2003. p. 721.

Tanwar YS, Jain AK. Formulation and evaluation of topical diclofenac sodium gel using different gelling agent. Asian J Pharm Res Healthc 2012;4(1):1-6.

Kumar TG, Kaur LP. Formulation and evaluation of topical gel of aceclofenac. J Drug Deliv Ther 2013;3(6):51-3.

Vinay W, Mohan MV, Manjunath SY. Formulation and evaluation of stomach specific in-situ gel of metoclopramide using natural, bio‑degradable polymers. Int J Res Pharm Biomed Sci 2011;2(1):193‑201.

Kaur LP, Garg R, Gupta GD. Development and evaluation of topical gel of minoxidil from different polymer bases in application of alopecia. Int J Pharm Pharm Sci 2010;2(3):43-7.

Ramchandani U, Sangameswaran B. Formulation and evaluation of topical gel of ketoprofen using different polymers. Int J Pharm Biol Arch 2013;4(2):323-6.

Jain D, Pathak K. Design, characterization, and evaluation of meloxicam gel prepared by suspension and solution polymerization using solubility parameter as the basis for development. AAPS PharmSciTech 2010;11(1):133-42.

Sakore S, Chakraborty B. Formulation and evaluation of enalapril maleate sustained release matrix. Int J Pharm Biomed Res 2013;4(1):21‑6.

Xin C, Lihong W, Qiuyuan L, Hongzhuo L. Injectable long-term control-released in situ gels of hydrochloric thiothixene for the treatment of schizophrenia: preparation, in vitro and in vivo evaluation. Int J Pharm 2014;469(1):23-30.

Published

01-03-2015

How to Cite

Das, S., A. Samanta, and A. Bose. “DESIGN, DEVELOPMENT AND EVALUATION OF FLUCONAZOLE TOPICAL GEL”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 2, Mar. 2015, pp. 132-5, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/4406.

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Original Article(s)