A RANDOMIZED CONTROLL TRIAL TO COMPARE THE EFFICACY OF SACCHAROMYCES BOULARDII, BACILLUS CLAUSII, AND LACTOBACILLUS RHAMNOSUS GG PREPARATION IN THE TREATMENT OF ACUTE DIARRHEA IN CHILDREN

Authors

  • ABHISHEK KUMAR SHARMA Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India. https://orcid.org/0000-0002-2358-1923
  • NEERAJ PURI Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.
  • MADHU MATHUR Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India. https://orcid.org/0000-0003-0780-6958
  • AMIT MATHUR Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i4.44199

Keywords:

Probiotics, Saccharomyces Boulardii, Bacillus Clausii, Lactobacillus RhamnosusGG

Abstract

Objective: Probiotics have been recommended as an adjunct to standard treatment of acute diarrhea but the choice of probiotics is unclear. The aim of study is to compare the efficacy of Saccharomyces boulardii, Bacillus clausii versus Lactobacillus rhamnosus in children with acute diarrhea and to expand the tolerability of S. boulardii, B. clausii versus L. rhamnosus GG in acute diarrhea.

Methods: Hospital based Randomized Controlled Clinical trial (chit in box) carried out at the Department of Pediatrics, Mahatma Gandhi Hospital, Jaipur Rajasthan from January 2020 to June 2021. 120 Children were enrolled in the study and randomized to either Group A or Group B or Group C. Group A received S. boulardii, Group B received B. clausii and Group C received L. rhamnosus GG. Sample size was 40 samples for each group. Statistical analysis was done with the SPSS software.

Results: There was statistically significant improvement in consistency observed in Group C as compared to Group A an Group B (p<0.001). Significant higher cases (87.5%) were improved in Group C compare to Group B (67.5%), followed by Group A (65%). While all patients were observed well tolerated and accepted during the study.

Conclusions: In our study, L. rhamnosus GG significantly reduce the frequency, improve the consistency of stools in diarrhea as compared to B. clausii and S. boulardii while tolerability of S. boulardii, B. clausii and L. rhamnosus GG was good with no adverse effect.

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Author Biographies

MADHU MATHUR, Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

Professor,

Department of pediatrics,

Mahatma Gandhi Medical College & Hospital, Jaipur

AMIT MATHUR, Department of Pediatrics, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

JUNIOR RESIDENT,

DEPARTMENT OF PEDIATRICS, 

MAHATMA GANDHI MEDICAL COLLEGE & HOSPITAL, JAIPUR

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Published

07-04-2022

How to Cite

SHARMA, A. K., N. PURI, M. MATHUR, and A. MATHUR. “A RANDOMIZED CONTROLL TRIAL TO COMPARE THE EFFICACY OF SACCHAROMYCES BOULARDII, BACILLUS CLAUSII, AND LACTOBACILLUS RHAMNOSUS GG PREPARATION IN THE TREATMENT OF ACUTE DIARRHEA IN CHILDREN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 15, no. 4, Apr. 2022, pp. 63-67, doi:10.22159/ajpcr.2022.v15i4.44199.

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