A COMPARATIVE STUDY OF FETOMATERNAL OUTCOME IN WOMEN WITH OLIGOHYDRAMNIOS INDUCED WITH MISOPROSTOL

ANJLINA BHATI; JYOTI NAGAR; MAYANKJAIN; MONIKA RAHAR; SURENDRASINGH; AISHWARYA RAVIKRISHAN

doi:10.22159/ajpcr.2022.v15i10.45370

Authors

ANJLINA BHATI Department of Obstetrics and Gynaecology, Jhalawar Medical College, Jhalawar, Rajasthan, India. https://orcid.org/0000-0003-3680-2948
JYOTI NAGAR Department of Obstetrics and Gynaecology, Jhalawar Medical College, Jhalawar, Rajasthan, India.
MAYANKJAIN Department of PSM, Jhalawar Medical College, Jhalawar, Rajasthan, India.
MONIKA RAHAR Department of Obstetrics and Gynaecology, Jhalawar Medical College, Jhalawar, Rajasthan, India.
SURENDRASINGH Department of General Medicine, Jhalawar Medical College, Jhalawar, Rajasthan, India.
AISHWARYA RAVIKRISHAN Department of General Medicine, Jhalawar Medical College, Jhalawar, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i10.45370

Keywords:

FETOMATERNAL OUTCOME, OLIGOHYDRAMNIOS, INDUCTION WITH MISOPROSTOL

Abstract

Objectives: The objectives of this study were to compare the effect of misoprostol on fetomaternal outcome among women with oligohydramnios and normal amniotic fluid.

Methods: An intervention study was carried out at Obstetrics and Gynecology Department of Jhalawar Medical College during September 2021–February 2022. Based on inclusion and exclusion criteria, 42 women with oligohydramnios at term gestation (Group I) and 42 matched control (Group II) were enrolled in the study. All women were undergone for induction of labor using 50 microgram misoprostol. Data were entered and analyzed using SPSS 23.0 software.

Results: Mean age of Group I was 25.9±4.3 and Group II was 26.4±5.8 years. Nearly, equal dose of misoprostol was required to induce labor in both groups (p=0.28). Induction to delivery interval was significantly different (p=0.0001) in both group. Vaginal or assisted vaginal delivery was occur in 26 (61.90%) and 23 (54.76%) in Group I and Group II. Meconium staining was found significantly higher (p=0.033) among Group I (13, 30.95%) than Group II (05, 11.90%). APGAR score <7 at 1 min was found in 11 (26.19%) in Group I and 04 (9.52%) in Group II p=0.046).

Conclusion: Labor induction at term with misoprostol in both groups did not show significant difference as far as maternal outcome was concerned, although it does affect neonatal parameters in terms of meconium staining and APGAR score.

Downloads

Download data is not yet available.

References

Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Williams Obstetrics. 23rd ed. New York: McGraw-Hill; 2010.

National Health Data Authority; 1997. Available from: https://www.esundhed.dk/Emner#tabpanel61119A7221 6248AC86DB508579760DED [Last accessed on 2019 May 12].

Sanchez-Ramos L. Induction of labour. Obstet Gynecol Clin North Am 2005;32:181-200. doi: 10.1016/j.ogc.2004.12.004, PMID 15899354

World Health Organization. Recommendations for Induction of Labour. Geneva: World Health Organization; 2011.

Biradar KD, Shamanewadi AN. Maternal and perinatal outcome in oligohydramnios: Study from a tertiary care hospital, Bangalore, Karnataka, India. Int J Reprod Contracept 2016;5:2291-4. doi: 10.18203/2320-1770.ijrcog20162113

Amir F, Ara G, Basharat A, Amir S. Fetomaternal outcome in women with oligohydramnios induced with misoprostol. J Ayub Med Coll Abbottabad 2019;31:407-10. PMID 31535516

Divon MY, Marks AD, Henderson CE. Longitudinal measurement of amniotic fluid index in postterm pregnancies and its association with fetal outcome. Am J Obstet Gynecol 1995;172:142-6. doi: 10.1016/0002-9378(95)90103-5, PMID 7847525

ACOG committee opinion no. 560: Medically indicated late-preterm and early-term deliveries. Obstet Gynecol 2013;121:908-10. doi: 10.1097/01.AOG.0000428648.75548.00, PMID 23635709

ACOG practice bulletin no. 107: Induction of labor. Obstet Gynecol 2009;114:386-97. doi: 10.1097/AOG.0b013e3181b48ef5, PMID 19623003

Alfirevic Z, Aflaifel N, Weeks A. Oral misoprostol for induction of labour. Cochrane Database Syst Rev 2014;6:CD001338.

Carlan SJ, Blust D, O’Brien WF. Buccal versus intravaginal misoprostol administration for cervical ripening. Am J Obstet Gynecol 2002;186:229-33. doi: 10.1067/mob.2002.119630, PMID 11854640

Thakur S, Singh K, Saroha I, Sharma P, Sharma J. To study the perinatal outcome in women with labor induction by sublingual vs. Vaginal misoprostol. Ann Pediatr Res 2020;4:1030.

Yadav S, Shah P, Patel RV, Chavda A, Shah MK. Oligohydramnios: A common problem with increasing incidence in term pregnancy and its fetomaternal outcome. WJPMR 2019;5:181-3.

Hofmeyr GJ, Gülmezoglu AM, Pileggi C. Vaginal misoprostol for cervical ripening and induction of labour. Cochrane Database Syst Rev 2003;1:CD000941. doi: 10.1002/14651858.CD000941.pub2

Danielian P, Porter B, Ferri N, Summers J, Templeton A. Misoprostol for induction of labour at term: A more effective agent than dinoprostone vaginal gel. Br J Obstet Gynaecol 1999;106:793-7. doi: 10.1111/j.1471- 0528.1999.tb08399.x, PMID 10453828