EFFECTS OF AQUEOUS EXTRACT OF PURIFIED CURCUMA LONGA ON MOTOR PERFORMANCE IN MICE

ASHISH SHARMA; ARNAV SHARMA

doi:10.22159/ajpcr.2023.v16i4.45731

Authors

ASHISH SHARMA Department of Pharmacology, Adesh Medical College and Hospital, Shahbad, Haryana, India.
ARNAV SHARMA Department of Psychiatry, LHMC and Associated Hospitals, New Delhi, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i4.45731

Keywords:

Curcuma longa, Aqueous extract, Motor performance

Abstract

Objective: This study was performed to see the effects of aqueous extract of purified Curcuma longa (CL) on motor performance of albino mice using rota test.

Methods: CL at 50mg/kg body weight (b.w.) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±2 standard deviation, p was set at < 0.05. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney U-test.

Results: As compared to CL200, DW (distilled water 10 ml/kg p.o.) group fall off time was significantly less (p=0.004). Diazepam (5 mg/kg i.p.) group stayed for lesser time on the rotating rod than CL50, CL100, and CL200 groups (p=0.004). Fall off time in CL100 group was significantly lesser than CL 200 group (p=0.019).

Conclusion: This study showed that CL possesses motor performance increasing effects at 200 mg.

Downloads

Download data is not yet available.

References

Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett 1995;94:79-83.

Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol 1995;47:59-67.

Balakrishnan KV. Postharvest technology and processing of turmeric. In: Ravindran PN, Babu KN, Sivaraman K, editors. Turmeric: The Genus Curcuma. 1st ed. Boca Raton, FL: CRC Press; 2007. p. 193-256.

Goud VK, Polasa K, Krishnaswamy K. Effect of turmeric on xenobiotic metabolising enzymes. Plant Foods Hum Nutr 1993;44:87-92.

Ohshiro M, Kuroyanag M, Keno A. Structures of sesquiterpenes from Curcuma longa. Phytochemistry 1990;29:2201-5.

Kapoor LD. Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press; 1990.

Kirtikar KR, Basu BD, Blatter E, Caius JF, Mhaskar KS. In: Basu LM, editor. Indian Medicinal Plants. 2nd ed. Allahabad, India: Lalit Mohan Basu; 1993. p. 1182.

Peterson CM, Johannsen DL, Ravussin E. Skeletal muscle mitochondria and aging: A review. J Aging Res 2012;2012:194821.

Hood DA, Uguccioni G, Vainshtein A, D’souza D. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle: Implications for health and disease. Compr Physiol 2011;1:1119-34.

Hamidie RD, Yamada T, Ishizawa R, Saito Y, Masuda K. Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism 2015;64:1334-47.

Huang HC, Jan TR, Yeh SF. Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur J Pharmacol 1992;221:381-4.

INSA. Guidelines for Care and Use of Animals in Scientific Research. New Delhi: INSA; 2012.

Baxla SL, Gora RH, Kerketta P, Kumar N, Roy BK, Patra PH. Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats. Vet World 2013;6:664-7.

Kumar R, Gupta D, Mukul S, Singh AK, Kumar A, Ali MD, et al. Effect of Curcuma longa on ovary of endosulfan exposed mice. IJPBA 2012;3:617-21.

Diehl KH, Hull R, Morton D, Pfister R, Rabemampianina Y, Smith D, et al. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol 2001;21:15-23.

Tsuda M, Suzuki T, Misawa M, Nagase H. Involvement of the opioid system in the anxiolytic effect of diazepam in mice. Eur J Pharmacol 1996;307:7-14.

Kalakonda R, Kadiri SK. Screening of skeletal muscle relaxant activity of plant Vicia faba. Int J Pharm 2013;4:237-40.

Egerman MA, Glass DJ. Signaling pathways controlling skeletal muscle mass signaling pathways controlling skeletal muscle mass. Crit Rev Biochem Mol Biol 2014;49:59-68.

Kim KY, Ku SK, Lee KW, Song H, An WG. Muscle-protective effects of Schisandrae fructus extracts in old mice after chronic forced exercise. J Ethnopharmacol 2018;212:175-87.

Gumucio JP, Mendias CL. Atrogin-1, MuRF-1, and sarcopenia. Endocrine 2013;43:12-21.

Kim S, Kim K, Park J, Jun W. Curcuma longa L. Water extract improves dexamethasone-induced sarcopenia by modulating the muscle-related gene and oxidative stress in mice. Antioxidants (Basel) 2021;10:1000.

Ono T, Takada S, Kinugawa S, Tsutsui H. Curcumin ameliorates skeletal muscle atrophy in Type 1 diabetic mice by inhibiting protein ubiquitination. Exp Physiol 2015;100:1052-63.

Labban L. Medicinal and pharmacological properties of Turmeric (Curcuma longa): A review. Int J Pharm Biomed Res 2014;5:17-23.

Kobori M, Takahashi Y, Akimoto Y, Sakurai M, Matsunaga I, Nishimuro H, et al. Chronic high intake of quercetin reduces oxidative stress and induces expression of the antioxidant enzymes in the liver and visceral adipose tissues in mice. J Funct Foods 2015;15:551-60.

Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S. Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact 2012;195:154-64.