A  study to assess Vitamin D deficiency and its association with sepsis in tertiary care centre

RUPESH KUMAR SINGH; ujjwal sourav

doi:10.22159/ajpcr.2022.v15i11.45793

Authors

RUPESH KUMAR SINGH Senior neonatologist, Yashshvi hospital, patna
ujjwal sourav assistant professor, Saraswathi Institute of medical sciences

DOI:

https://doi.org/10.22159/ajpcr.2022.v15i11.45793

Keywords:

sepsis, CRP, vit D, TLC

Abstract

Introduction : Sepsis is a life threatening organ dysfunction generated due to the dysregulation of the immune response to infection. A high mortality rate in sepsis is the result of multiple organ failure which often follows sepsis. Recent studies have shown the correlation between vitamin D deficiency and severe infections and sepsis

Aim and objective : To evaluate the correlation between serum levels of vitamin D and outcome of sepsis patients presenting to ED.

Methodology : This cross sectional study was performed in the Saraswathi institute of medical sciences, Hapur from October 2021 to March 2022. For all the eligible patients, blood sample was drawn for measuring serum level of vitamin D and finally the correlation between the level of this vitamin and the studied outcomes was evaluated.

Result : The mean vit d level of the study subjects who get cured were 23.09±11.20, whereas those patients who died had vit d level 16.12±10.60, on comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02. On assessing vit D level with TLC of study subjects, on applying regression analysis we found no correlation between vitd level and TLC value of the study subjects with R square 0.

Conclusion : On the basis of our study we can conclude that There is significant association of serum vit d level with outcome of sepsis in the study subjects. On comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02, CRP increases generally in infections, it was associated with vit D level, however association was statistically non-significant.

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Author Biography

RUPESH KUMAR SINGH, Senior neonatologist, Yashshvi hospital, patna

Senior neonatologist

References

Agrawal A, Gupta A. Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis : A Case – Control Study. Journal of Tropical Pediatrics, 2019;4:609–16.

Pant A, Mackraj I, Govender T. Advances in sepsis diagnosis and management : a paradigm shift towards nanotechnology. J Biomed Sci [Internet]. 2021;1–30. Available from: https://doi.org/10.1186/s12929-020-00702-6

Rajkondawar A, Karde D. Prevalence and association of Vitamin D Deficiency and Mortality in patients with Severe Sepsis. 2020;29(6):38–46.

Kiran M, Das S, Biswal N, Parameswaran N. Vitamin D Status at Admission and Its Association With Mortality in Children Admitted to the Pediatric Intensive Care Unit. 2020;12(6):1-7

Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis : a systematic review. BMC Anesthesiology, 2015; 15:84-9

Kempker JA, Tangpricha V, Ziegler TR, Martin GS. Vitamin D in sepsis : from basic science to clinical impact. . Critical Care 2012; 16:316-22

Ponnarmeni S, Angurana SK, Singhi S, Bansal A, Dayal D, Kaur R, et al. Vitamin D deficiency in critically ill children with sepsis. Paediatr Int Child Health. 2016;36(1):15–21.

Kafle SP, Ahmad E, Rauniyar LP, Koirala N. Vitamin D Deficiency among Children with Sepsis in a Tertiary Care Center in Eastern Nepal. J Univers Coll Med Sci. 2021;9(02):45–9.

Bayat M, Gachkar L, Zahirnia M, Hadavand F. Association between low serum vitamin d levels and sepsis: A single-center study in tehran, iran. Arch Clin Infect Dis. 2021;16(1):4–7.

bankole PK . Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in Nigerian children with asthma, Journal of Asthma, 2021;58(5):1-7

Murdoch DR, Slow S, Chambers ST, Jennings LC, Stewart AW, Priest PC, et al. Effect of vitamin D 3 supplementation on upper respiratory tract infections in healthy adults: The VIDARIS randomized controlled trial. JAMA - J Am Med Assoc. 2012;308(13):1333–9.

mark loeb. Randomized controlled trial of influenza vaccine in patients with heart failure to reduce adverse vascular events (IVVE): Rationale and design, Am Heart J. 2019 ; 212: 36–44.

Şişmanlar T, Aslan AT, Gülbahar Ö, Özkan S. The effect of vitamin D on lower respiratory tract infections in children. Turk Pediatr Ars. 2016;51(2):94–9.

Parekh D, Patel JM, Scott A, Lax S, Dancer RC, D'Souza V, Greenwood H, Fraser WD, Gao F, Sapey E, Perkins GD, Thickett DR. Vitamin D deficiency in human and murine sepsis. Crit Care Med. 2017 ;45(2):282-9

Megan A. Rech, Todd Hunsaker, DEFICIENCY IN 25-HYDROXYVITAMIN D AND 30-DAY MORTALITY IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK, C AMERICAN JOURNAL OF CRITICAL CARE, 2014; 23(5): e73-9

Nguyen HB, Eshete B, Lau KHW, Sai A, Villarin M, Baylink D. Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis. PLoS One. 2013;8(5):1–9.

arnson Y. Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients, QJM. 2012 ;105(7):633-9

adrian kruit. The association between vitamin D and C-reactive protein levels in patients with inflammatory and non-inflammatory diseases, Clinical Biochemistry,2016;49 (7):534-537