FORMULATION AND IN VITRO CHARACTERIZATION OF THIOCOLCHICOSIDE PRONIOSOMES FOR ORAL DELIVERY

Authors

  • Deepa Antil Department of Pharmaceutics, Hindu College of Pharmacy, Sonipat, Haryana, India.
  • Rahul Sharma Department of Pharmaceutics, Hindu College of Pharmacy, Sonipat, Haryana, India.
  • BHARAT BHUSHAN Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Sonipat, Haryana, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i4.46456

Keywords:

Thiocolchicoside, Proniosomes, Niosomes, Controlled release, Particle size, In-vitro release

Abstract

Objective: The main objective of the present study was to develop a controlled release formulation of proniosomes of thiocolchicoside.

Methods: The formulations of proniosomes were prepared with thiocolchicoside varying the Span 60 and cholesterol ratio in the range of 4.5:1–1:4.5 using sucrose stearate as carrier by slurry method. The different proniosomal formulations prepared were characterized for micromeritic properties and further %Entrapment efficiency, %Drug content, and loading efficiency were also determined. The best optimized formulation F8 was characterized for particle size distribution, zeta potential, scanning electron microscopy, in vitro dissolution studies, and in vitro release kinetics to determine the release pattern of the drug from the formulation. Further, the formulated proniosomes were subjected to stability studies.

Results: The Fourier-transform infrared spectroscopy study showed no interaction between drugs and other excipients. The entrapment efficiency of proniosomes formulations found within the range of 49.71–83.62%. The formulation F8 was characterized for the in vitro dissolution studies which showed drug release 94.30% within 24 h when compared with pure drug. Kinetic analysis of drug release profiles showed that the drug release was followed by Korsmeyer–Peppas model (R2=0.9413) resulted in controlled release. The mean particle size and zeta potential of proniosome derived niosomes were found to be 118.34 nm with polydispersity index 14.9% and −36.8, respectively, and has reasonably good stability characteristics as well.

Conclusion: Proniosomal formulation of thiocolchicoside may be used as controlled drug delivery system for oral administration. Hence, proniosomes could act as a promising alternative option for oral drug delivery.

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References

Patil S, Mhaiskar A, Mundhada D. A review on novel drug delivery system: A recent trend. Int J Curr Pharm Res 2016;6:89-93.

Adepu S, Ramakrishna S. Controlled drug delivery systems: Current status and future directions. Molecules 2021;26:1-48. doi: 10.3390/ molecules26195905, PMID 34641447

Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system: New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 2000;50:3- 12. doi: 10.1016/s0939-6411(00)00091-6, PMID 10840189

Kumar R, Kumar S, Jha SS, Jha AK. Vesicular system-carrier for drug delivery. Der Pharmacia Sinica 2011;2:192-202.

Betageri G, Habib M. Liposomes as drug carriers. Pharm Eng 1994;14:76-7.

Schreier H, Bouwstra J. Liposomes and niosomes as topical drug carriers: Dermal and transdermal drug delivery. J Control Release 1994;30:1-15. doi: 10.1016/0168-3659(94)90039-6

Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The preparation and properties of niosomes-non-ionic surfactant vesicles. J Pharm Pharmacol 1985;37:863-8. doi: 10.1111/j.2042-7158.1985. tb04990.x, PMID 2868092

Blazek-Welsh AI, Rhodes DG. Maltodextrin-based proniosomes. AAPS PharmSci 2001;3:E1. doi: 10.1208/ps030101, PMID 11741252

Gurrapu A, Jukanti R, Bobbala SR, Kanuganti S, Jeevana JB. Improved oral delivery of valsartan from maltodextrin based proniosome powders. Adv Powder Technol 2012;23:583-90. doi: 10.1016/j.apt.2011.06.005

Umarkar AR, Bavaskar SR, Yewale PN. Thiocolchicoside as muscle relaxant: A review. Int J Pharm Biol Sci 2011;1:364-71.

Shukla T, Pandey SP, Upmanyu N. Simultaneous estimation of thiocolchicoside and ketorolac tromethamine using UV spectroscopy. J Indian Chem Soc 2019;96:305-10.

Sachan AK, Kumar S, Singh S, Kumari K, Kumar K. Formulation and evaluation of floating microsphere of muscle relaxant drug thiocolchicoside. J Chem Pharm Res 2020;12:40-9.

Kumar D, Ali J, Baboota S. Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: Formulation, characterization and absorption studies. Drug Deliv 2016;23:591-600. doi: 10.3109/10717544.2014.916764, PMID 24892633

Patel TB, Patel TR, Patel MN, Suhagia BN. Design and development of ethosomes for enhanced transdermal delivery of thiocolchicoside. Pharm Lett 2015;7:58-68.

Rele VR. UV-spectrophotometric estimation of thiocolchicoside by derivative method in pharmaceutical dosage form. Pharm Lett 2015;7:221-6.

Khatoon M, Shah KU, Din FU, Shah SU, Ur Rehman A, Dilawar N, et al. Proniosomes derived niosomes: Recent advancements in drug delivery and targeting. Drug Deliv 2017;2:56-69.

Ravi GS, Charyulu NR, Dubey A, Hebbar S, Mathias AC. Phytosomes: A novel molecular nanocomplex between Phyto molecule and phospholipid as a value-added herbal drug delivery system. Int J Pharm Sci Rev Res 2018;51:84-90.

Nasr A, Qushawy M, Swidan S. Spray dried lactose based proniosomes as stable provesicular drug delivery carriers: Screening, formulation, and physicochemical characterization. Int J Appl Pharm 2018;10:125- 37. doi: 10.22159/ijap.2018v10i5.27732

Bhalerao A, Chaudhari PP. Formulation of Solid lipid nanoparticles of cilnidipine for the treatment of hypertension. J Drug Deliv Ther 2019;9:212-21. doi: 10.22270/jddt.v9i3.2849

Katrolia A, Chauhan SB, Shukla VK. Formulation and evaluation of metformin hydrochloride loaded curcumin-lycopene Niosomes. SN Appl Sci 2019;1:1-6. doi: 10.1007/s42452-019-1768-6

Annepogu H, Ahad HA, Nayakanti D. Determining the best poloxamer carrier for thiocolchicoside solid dispersions. Turk J Pharm Sci 2020;17:372-80. doi: 10.4274/tjps.galenos.2019.78800, PMID 32939132

Veerareddy PR, Bobbala SK. Enhanced oral bioavailability of isradipine via proniosomal systems. Drug Dev Ind Pharm 2013;39:909-17. doi: 10.3109/03639045.2012.717945, PMID 22998221

Cheriyan P, George BJ, Thomas N, Raj P, Samuel J, Carla SB. Formulation and characterization of maltodextrin based proniosomes of cephalosporins. World J Pharm Res 2015;3:62-74.

Published

07-04-2023

How to Cite

Antil, D., R. Sharma, and B. BHUSHAN. “FORMULATION AND IN VITRO CHARACTERIZATION OF THIOCOLCHICOSIDE PRONIOSOMES FOR ORAL DELIVERY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 16, no. 4, Apr. 2023, pp. 114-21, doi:10.22159/ajpcr.2023.v16i4.46456.

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