COCHLEAR SYNAPTIC TINNITUS – CAN IT BE CURED
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i2.46520Keywords:
Tinnitus, Cochlear origin, Hearing loss, Audiogram, Carbamazepine, PiracetamAbstract
Objective: The objective of this study was to determine the tinnitus demography, etiology, treatment options, and their response in a Tertiary Care Teaching Hospital.
Methods: The study was conducted on patients above 21 and below 80 years who presented with tinnitus and hearing loss to ENT outpatient department (OPD) of Dr. Patnam Mahender Reddy Institute of Medical Sciences (PMRIMS), Chevella from May 2019 to February 2020. To identify the cause of tinnitus, the following investigations were considered: Pure-tone audiogram; tympanometry; blood investigations, color Doppler ultrasonography to evaluate blood flow disturbance in the vertebral and basilar artery, middle/inner ear high-resolution computerized tomography scan (CT), and, in the case of suspicion of vestibular Schwannoma or neurovascular conflict, magnetic resonance imaging/angio-CT (MRI/Angio-CT) was done.
Results: Among the patients attending ENT OPD with tinnitus, those with idiopathic cochlear synaptic tinnitus were identified, and 100 were selected and treated with various modalities of pharmacological treatment available for the same found that no specific drug was 100% effective in relieving the symptom.
Conclusion: The present study treated tinnitus of cochlear origin with various drugs and followed up with patients for 3 months. They were assessed with tinnitus sample case history questionnaire, and the study concluded that no pharmacological treatment effectively treats cochlear synaptic tinnitus.
Downloads
References
Borka C, Luxon ML. Scott Brown’s Otorhinolaryngology and Head and Neck Surgery. 7th ed., Vol. 3. Great Britain: Edward Arnold Ltd.; 2008. p. 3594-619.
Crummer RW, Hassan GA. Diagnostic approach to Tinnitus. Am Fam Phys 2004;69:120-6. PMID 14727828
Ahmad N, Seidman M. Tinnitus in the older adult: Epidemiology, pathophysiology and treatment options. Drugs Aging 2004;21:297-305. doi: 10.2165/00002512-200421050-00002, PMID 15040757
Deka RC. Causes, pathogenesis, diagnosis and management of tinnitus. Indian J Otol 2005;11:3-5.
Dobie RA. Overview: Suffering from tinnitus. In: Snow JB, editor. Tinnitus: Theory and Management. Ontario: B C Decker Inc.; 2004. p. 1-7.
Neri G, De Stefano A, Baffa C, Kulamarva G, Di Giovanni P, Petrucci G, et al. Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: Personal experience from a randomized controlled study. Acta Otorhinolaryngol Ital 2009;29:86- 91. PMID 20111618
Claussen CF. Rakel and bope. In: Conn’s Current Therapy. 60th ed. Philadelphia, PA: Elsevier Inc.; 2008.
Jacobson GP, McCaslin DL. A search for evidence of a direct relationship between Tinnitus and suicide. J Am Acad Audiol 2001;12:493-96. doi: 10.1055/s-0042-1745639, PMID 11791935
Hazell JW, Jastreboff PJ. Tinnitus: Auditory mechanisms: A model for tinnitus and hearing impairment. J Otolaryngol 1990;19:1-5. PMID 2179573
Atik A. Pathophysiology and treatment of Tinnitus: An elusive disease. Indian J Otolaryngol Head Neck Surg 2014;66:1-5. doi: 10.1007/ s12070-011-0374-8. PMID 24533352, PMCID PMC3918281
Hoekstra CE, Rynja SP, van Zanten GA, Rovers MM. Anticonvulsants for tinnitus. Cochrane Database Syst Rev 2011;2011:CD007960. doi: 10.1002/14651858.CD007960.pub2, PMID 21735419, PMCID PMC6599822
Hulshof JH, Vermeij P. The value of carbamazepine in the treatment of tinnitus. ORL J Otorhinolaryngol Relat Spec 1985;47:262-6. doi: 10.1159/000275781, PMID 3900856
Hulshof JH, Vermeij P. The value of flunarizine in the treatment of Tinnitus. ORL J Otorhinolaryngol Relat Spec 1986;48:33-6. doi: 10.1159/000275839, PMID 3513083
Donaldson I. Tegretol: A double-blind trial in Tinnitus. J Laryngol Otol 1981;95:947-51. doi: 10.1017/s0022215100091659, PMID 7026707
Sanchez TG, Balbani AP, Bittar RS, Bento RF, Câmara J. Lidocaine test in patients with Tinnitus: Rationale of accomplishment and relation to the treatment with carbamazepine. Auris Nasus Larynx 1999;26:411-7. doi: 10.1016/s0385-8146(99)00020-6, PMID 10530736
Langguth B, Salvi R, Elgoyhen AB. Emerging pharmacotherapy of Tinnitus. Expert Opin Emerg Drugs 2009;14:687-702. doi: 10.1517/14728210903206975, PMID 19712015, PMCID PMC2832848
Denk DM, Heinzl H, Franz P, Ehrenberger K. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol 1997;117:825-30. doi: 10.3109/00016489709114208, PMID 9442821
Saletu B, Grünberger J, Anderer P, Linzmayer L, König P. On the cerebral-protective effects ofcaroverine, a calcium-channel blocker and anti-glutamatergic drug: Double-blind, placebo-controlled, EEG mapping and psychometric studies under hypoxia. Br J Clin Pharmacol 1996;41:89-99. doi: 10.1111/j.1365-2125.1996.tb00165.x, PMID 8838434
Published
How to Cite
Issue
Section
Copyright (c) 2022 Sowmya Ramarappu Sowmya, Mahesh Dasari
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
