ANTIDEPRESSANT EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA COMPARED WITH IMIPRAMINE IN MICE MODELS

FLOYD VERNON DSOUZA; JAYARAJ M; HALMOND MELROYD DSOUZA

doi:10.22159/ajpcr.2023.v16i1.46988

Authors

FLOYD VERNON DSOUZA Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Center, Mangaluru, Karnataka, India.
JAYARAJ M Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Center, Mangaluru, Karnataka, India.
HALMOND MELROYD DSOUZA Department of Pharmacology, Clinical Practice, Mangaluru, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i1.46988

Keywords:

Antidepressants, Imipramine, Mimosa pudica

Abstract

Background: Depression was considered as mental illness worldwide. Various symptoms observed with depression are loss of interest, sad mood, disturbed sleep, low energy, and loss of appetite. Mimosa pudica is a traditional medicine having various medicinal properties. Imipramine is a tricyclic antidepressant drug used in depression. This study is to evaluate the antidepressant activity of ethanolic extract of M. pudica leaves and imipramine in mice models.

Methods: Swiss albino mice weighing 20–25 g of either sex was involved in study. In each study, the animals were divided into five groups (n=6). Drug was administered i.p. and the antidepressant activity was performed using tail suspension test (TST) and forced swim test (FST) in Group 1 – control group, Group 2 received imipramine (10 mg/kg), and Groups 3, 4, and 5 received M. pudica extract of (4, 6, 8 mg/kg).

Results: The study shows the significant reduction in immobility in acute and chronic study of TST and FST with M. pudica extract of (6 mg/kg) and imipramine when compared with control and other extracts of M. pudica (4 mg/kg and 8 mg/kg)

Conclusions: The study concluded that the ethanolic extract of M. pudica has significant antidepressant activity and can be, further, considered for the treatment of depression.

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