COMPARISON OF CYTOLOGICAL AND HISTOPATHOLOGICAL FINDINGS IN BREAST LESIONS – A TERTIARY CARE CENTER

Patel Hani Bharatkumar; Matariswa Samanta; Pawan Nikhra; Vishakha Behl; Patel Ujaskumar Ashvinbhai

doi:10.22159/ajpcr.2023.v16i6.47558

Authors

Patel Hani Bharatkumar Post Graduate, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
Matariswa Samanta Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
Pawan Nikhra Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
Vishakha Behl Assistant Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.
Patel Ujaskumar Ashvinbhai Assistant Professor, Department of General Surgery, American International Institute of Medical Sciences, Udaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i6.47558

Keywords:

Breast lump, Fine needle aspiration cytology, Histopathology

Abstract

Objective: The objective of the study was to compare the findings of cytological and histopathological features of breast lesions.

Methods: This study conducted on 109 patients with breast lump with fine needle aspiration cytology (FNAC) followed by histopathology at Department of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur, Rajasthan. The study duration is 18-month study period (April 2021 to September 2022).

Results: The mean age of the study subjects was 44.20 years with majority of the patients belonged to the age group 41–50 years (36.70%). Out of 109 cases, 84 cases (77.07%) were benign and 23 cases (21.10%) were malignant pathology in FNAC. Rest two cases had intermediate pathology. Majority of histopathological diagnosis of breast lumps in the present study were benign pathology (75.23%) and rest all malignant (24.77%).

Conclusion: Our study shows that FNAC can reliably distinguish between benign and malignant conditions and it is a sensitive and specific modality that assist in diagnosis and management of breast lesions. Although FNAC has been found to be a most valuable economic, simple, and safe diagnostic procedure, due to certain pitfall of FNAC like in case of pauci-cellularity blood mixed aspirates and blind technique procedure. Histopathological correlation is always mandatory for early diagnosis and better prognosis.

Downloads

Download data is not yet available.

Author Biographies

Matariswa Samanta, Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur, Rajasthan, India

Pawan Nikhra, Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Associate Professor, Department of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur, Rajasthan, India

Vishakha Behl, Assistant Professor, Department of Pathology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, India.

Assistant Professor, Department of Pathology, Pacific Institute of Medical Sciences, Umarda, Udaipur, Rajasthan, India

Patel Ujaskumar Ashvinbhai, Assistant Professor, Department of General Surgery, American International Institute of Medical Sciences, Udaipur, Rajasthan, India.

Assistant Professor, Department of General Surgery, American International Institute of Medical Sciences, Bedwas, Udaipur, Rajasthan

References

Daramola AO, Odubanjo MO, Obiajulu FJ, Ikeri NZ, Banjo AA. Correlation between fine-needle aspiration cytology and histology for palpable breast masses in a Nigerian tertiary health institution. Int J Breast Cancer 2015;2015:742573. doi: 10.1155/2015/742573, PMID 26635977

Arunraja KK. A Comparative Study Between FNAC, Trucut Biopsy and Histopathological Examination in Breast Lumps in Tirunelveli Medical College Hospital, Tirunelveli [Doctoral Dissertation]. Tirunelveli:Tirunelveli Medical College.

Rupom TU, Choudhury T, Banu SG. Study of fine needle aspiration cytology of breast lump: Correlation of cytologically malignant cases with their histological findings. Bangabandhu Sheikh Mujib Med Univ J 2011;4:60-4. doi: 10.3329/bsmmuj.v4i2.8631

Poudel S, Ranabhat S, Parajuli B, Pun G. Evaluation of breast lump by fine needle aspiration cytology. J Gandaki Med Coll Nepal 2016;9:38-42. doi: 10.3126/jgmcn.v9i2.17864

Adhikari RC, Jha A. Fine needle aspiration cytology findings of mucinous carcinoma of breast: A study of eight cases with histological correlation. J Pathol Nepal 2012;2:285-8. doi: 10.3126/jpn.v2i4.6879

Ibikunle DE, Omotayo JA, Ariyibi OO. Fine needle aspiration cytology of breast lumps with histopathologic correlation in Owo, Ondo State, Nigeria: A five-year review. Ghana Med J 2017;51:1-5. doi: 10.4314/ gmj.v51i1.1, PMID 28959065, PMCID PMC5611949

Chauhan SC, Sarvaiya AN. Cytological and histopathological correlation of breast lump: A 3 year study at tertiary care center. Ann Pathol Lab Med 2017;4:A292-6. doi: 10.21276/APALM.1380

Risaldar AA, Begum Z, Alvi U. Correlation of FNAC with histopathology of breast lesions. IP J Diagn Pathol Oncol 2020;5:375- 80. doi: 10.18231/j.jdpo.2020.073

Hatada T, Ishii H, Ichii S, Okada K, Fujiwara Y, Yamamura T. Diagnostic value of ultrasound-guided fine-needle aspiration biopsy, core-needle biopsy, and evaluation of combined use in the diagnosis of breast lesions. J Am Coll Surg 2000;190:299-303.

Ibrahim AE, Bateman AC, Theaker JM, Low JL, Addis B, Tidbury P, et al. The role and histological classification of needle core biopsy in comparison with fine needle aspiration cytology in the preoperative assessment of impalpable breast lesions. J Clin Pathol 2001;54:121-5. doi: 10.1136/jcp.54.2.121, PMID 11215280

Kumar PS, Mahesh GS. Clinical profile and correlation between FNAC and histopathology of breast lumps in a teaching hospital. Glob J Res 2014;14:2.

Homesh NA, Issa MA, El-Sofiani HA. The diagnostic accuracy of fine needle aspiration cytology versus core needle biopsy for palpable breast lump (s). Saudi Med J 2005;26:42-6. PMID 15756351

Pruthi S. Detection and evaluation of a palpable breast mass. Mayo Clin Proc 2001;76:641-7.; quiz 647-8. doi: 10.4065/76.6.641, PMID 11393504

Haas JS, Kaplan CP, Brawarsky P, Kerlikowske K. Evaluation and outcomes of women with a breast lump and a normal mammogram result. J Gen Intern Med 2005;20:692-6. doi: 10.1111/j.1525- 1497.2005.0149.x, PMID 16050876

Dawood SS, Lei X, Dent R, Mainwaring PN, Gupta S, Cortes J, et al. Impact of marital status on prognostic outcome of women with breast cancer. J Clin Oncol 2014;32 15 Suppl:594. doi: 10.1200/ jco.2014.32.15_suppl.594

Hirachand S, Lakhey M, Akthar J, Ghimire R, Dhakhwan R. Comparison of FNAC and open biopsy in palpable breast lumps. Health Renaiss 2010;7:9-12.

Vijayabharathi I, Bhagyalakshm A, Prasad JR, Kumar SS. Prospective study of CYTO histopathological correlation of breast lesions. J Evid Based Med Healthc 2015;2:3577-86. doi: 10.18410/jebmh/2015/513

Patrikar A, Maimoon S, Mahore S. Filarial granuloma in breast. Indian J Pathol Microbiol 2008;51:85-6. doi: 10.4103/0377-4929.40411, PMID 18417870

Sainsbury R. The breast. In: Williams NS, Ronan P, O’Connell CJK, editors. Bailey Love’s Short Practice of Surgery. 25th ed. United Kingdom: Bulstrode (Arnold Publication, Hodder); 2008. p. 827-50.

Amrikachi M, Green LK, Rone R, Ramzy I. Gynaecomastia: Cytological features and diagnostic pitfalls in fine needle aspirates. Acta Cytol 2001;45:948-52. doi: 10.1159/000328369, PMID 11726123

Kanchana PV, Ramalaxmi PV, Reddy KP, Raiza D. Cytohistological correlative study of breast lesions. J Evol Med Dent Sci 2015;4:4418- 28. doi: 10.14260/jemds/2015/639

Mansoor I. Profile of female breast lesions in Saudi Arabia. J Pak Med Assoc 2001;51:243-7. PMID 11558215

Aziz M, Ahmad N, Zahid J, Faizullah AM. Comparison of FNAC and open biopsy in palpable breast lumps. J Coll Physicians Surg Pak 2004;14:654-6. PMID 15533277

Nggada HA, Tahir MB, Musa AB, Gali BM, Mayun AA, Pindiga UH, et al. Correlation between histopathologic and fine needle aspiration cytology diagnosis of palpable breast lesions: A five-year review. Afr J Med Med Sci 2007;36:295-8. PMID 18564643

Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, et al. Breast cancer prognostic classification in the molecular era: The role of histological grade. Breast Cancer Res 2010;12:207. doi: 10.1186/ bcr2607. PMID 20804570, PMCID PMC2949637

Sikka M, Agarwal S, Bhatia A. Interobserver agreement of the Nottingham histologic grading scheme for infiltrating duct carcinoma breast. Indian J Cancer 1999;36:149-53. PMID 10921219