ROLE OF MRI IN EVALUATION OF SEIZURE DISORDER
DOI:
https://doi.org/10.22159/ajpcr.2023.v16i8.47754Keywords:
Seizures, Generalized tonic–clonic seizure, Myoclonic seizures, Infarct with gliosis, Ring-enhancing lesionsAbstract
Objectives: The present study was conducted to identify structural abnormalities on the brain imaging that may be associated with the cause of seizures and to study the spectrum of MRI findings in patients with seizures.
Methods: This time-bound descriptive study was conducted on 100 seizure patients in the department of radiodiagnosis of GMC, Patiala. Informed consent was obtained and then MR imaging of brain was done. The results were analyzed.
Results: Mean age was 39.59±15.96 years (range: 18–85 years) with 70% male and 30% female patients. The majority of the patients (80%) had generalized tonic–clonic seizures, followed by myoclonic seizures (8%), simple partial seizures (5%), complex partial seizures (2%), absence seizures (2%), motor seizures (1%), febrile seizures (1%), and tonic seizures (1%). The mean seizure duration was 2.15±1.48 months. On magnetic resource imaging (MRI), 44% patients had normal MRI. In remaining patients, MRI findings were infarct with gliosis (20%), ring enhancing lesions (18%), atrophy (6%), neoplasm (4%), thrombosis (3%), venous malformation (2%), and developmental malformations (3%).
Conclusion: The most common type of seizures is GTCS. MRI can be normal in the majority of the patients of seizures. Common MRI abnormalities were infarct with gliosis and ring-enhancing lesions. Hence, MRI plays a significant role in the initial evaluation of seizures patients to rule out any organic or developmental lesions.
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References
Stafstrom CE, Carmant L. Seizures and epilepsy: An overview for neuroscientists. Cold Spring Harb Perspect Med 2015;5:a022426. doi: 10.1101/cshperspect.a022426. PMID: 26033084; PMCID: PMC4448698
Kaculini CM, Tate-Looney AJ, Seifi A. The history of epilepsy: From ancient mystery to modern misconception. Cureus 2021;13:e13953. doi: 10.7759/cureus.13953. PMID: 33880289; PMCID: PMC8051941
Sander JW, Hart YM, Johnson AL, Shorvon SD. National General Practice Study of Epilepsy: Newly diagnosed epileptic seizures in a general population. Lancet 1990;336:1267-71. doi: 10.1016/0140- 6736(90)92959-l. PMID: 1978113
Fisher RS. The new classification of seizures by the international league against epilepsy 2017. Curr Neurol Neurosci Rep 2017;17:48. doi: 10.1007/s11910-017-0758-6. PMID: 28425015
Bernal B, Altman NR. Evidence-based medicine: Neuroimaging of seizures. Neuroimaging Clin N Am 2003;13:211-24. doi: 10.1016/ s1052-5149(03)00019-4. PMID: 13677802
Bonilha L, Montenegro MA, Cendes F, Li LM. The role of neuroimaging in the investigation of patients with single seizures, febrile seizures, or refractory partial seizures. Med Sci Monit 2004;10:RA40-6. PMID: 14976443
Duncan JS, Winston GP, Koepp MJ, Ourselin S. Brain imaging in the assessment for epilepsy surgery. Lancet Neurol 2016;15:420- 33. doi: 10.1016/S1474-4422(15)00383-X, PMID: 26925532; PMCID: PMC6736670
Narra, R, Putcha A, Yeshwanty, Penumatcha N. (2021). Mri evaluation of seizures: Study at a tertiary referral center in Southern India. Asian J Med Radiol Res 2021;9:20-6.
Chabarwal S, Kardam NK. Role of MRI in evaluation of seizure disorder in Southern Rajasthan, India. Int J Res Med Sci 2019;7:2095- 9. doi: 10.18203/2320-6012.ijrms20192479
Patel V, Maheshwari A, Sindhwani G, Bhatt J, Doshi J. MRI in epilepsy: A hope in the midst of a storm. Int J Anat Radiol Surg 2017;6:RO08-16. doi: 10.7860/IJARS/2017/28259:2280
Davagnanam I, Chen Z, Hoskote C, Ding D, Yang B, Wang Y, et al. Prevalence of MRI abnormalities in people with epilepsy in rural China. Neurology 2020;95:e1236-43. doi: 10.1212/WNL.0000000000010171, PMID: 32611640; PMCID: PMC7538231
Kushwah AP, Kedar K, Pande S. Role of MRI in evaluation of seizures. J Evol Med Dent Sci 2015;4:16977-83. doi: 10.14260/ JEMDS/2015/2564
Singh R, Kumari R, Prabhakaran T. Clinical spectrum and neuroimaging findings in children with seizures: A five-year retrospective study. Iran J Child Neurol 2022;16:157- 66. doi: 10.22037/ijcn.v16i4.35635, PMID: 36204443; PMCID: PMC9531203
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Copyright (c) 2023 DR NEERAJ SINGLA, Dr. Rajesh K Badhan, Dr Jarnail Singh, Dr Amarjit Kaur
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