IN VITRO PROTECTIVE EFFECT OF PROTEINS OF TERMINALIA CHEBULA FRUITS ACTION ON INHIBITION OF HEMOLYSIS, PROTEINASE, AND PROTEIN DENATURATION PROCESS

Omkar NG; Vedamurthy Joshi; Dinesha Ramadas

doi:10.22159/ajpcr.2023.v16i11.47985

Authors

Omkar NG Department of Physiology, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India.
Vedamurthy Joshi Department of Pharmaceutics, CORMIL and CMPAT, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India.
Dinesha Ramadas Department of Biochemistry, Adichunchanagiri School of Natural Sciences, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University, B.G. Nagara, Karnataka, India. https://orcid.org/0000-0002-8702-3357

DOI:

https://doi.org/10.22159/ajpcr.2023.v16i11.47985

Keywords:

Terminalia chebula fruits, Crude proteins, Anti-inflammatory activity, Proteinase inhibition, Haemolysis inhibition

Abstract

Objective: The study helps to evaluate the anti-inflammatory activity of Terminalia chebula fruit protein.

Methods: The crude protein extracted from T. chebula fruits was subjected to analysis for its hemolysis inhibitory, proteinase inhibitory, and protein denaturation inhibitory activities.

Results: In the antioxidant property model, the crude protein exhibited an inhibitory activity of 52% compared to 58% and 61% for ascorbic acid and alpha-tocopherol, respectively. In the hemolysis inhibition studies, the crude proteins demonstrated an inhibition of 42.1%. In the protein denaturation inhibitory study, the crude protein showed a maximum inhibition of 28%, while in the proteinase inhibitory studies, it exhibited a maximum inhibition of 43.1%.

Conclusion: The results of the study revealed that the crude proteins possess antioxidant and anti-inflammatory properties in various model systems.

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Author Biographies

Omkar NG, Department of Physiology, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India.

Department of Physiology, Shridevi Institute of Medical Sciences & Research Hospital, Tumkur, Karnataka

Vedamurthy Joshi, Department of Pharmaceutics, CORMIL and CMPAT, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India.

Professor, Dept. of Pharmaceutics, CORMIL & CMPAT, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara-571448, Karnataka, India

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