A CORRELATION STUDY OF BLOOD HBA1C WITH FASTING AND POSTPRANDIAL BLOOD GLUCOSE

Authors

  • PANKAJ KUMAR Department of Biochemistry, VIMS Palghar, Maharashtra, India
  • ABHAY NILKANTH NAGDEOTE Department of Biochemistry, ESIC Medical College and Hospital MIA, Alwar, Rajasthan, India
  • PARUL GUPTA Department of Biochemistry, GACH, Patna, India
  • AVINASH N JADHAO Department of Biochemistry, Seth GSMC and KEMH Parel, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.22159/ajpcr.2024.v17i4.49660

Keywords:

Blood glucose, HBA1C, Postprandial

Abstract

Objectives: This study aimed to evaluate the correlation between raised blood sugar and glycated hemoglobin (HbA1c), a gold standard test for the assessment of glycemic control. Serial monitoring of HbA1C in diabetes mellitus helps in the prevention of microvascular and macrovascular complications.

Methods: We retrospectively reviewed the laboratory reports of 397 patients who visited the hospital for various reasons. There were 195 males and 202 females in the study group. We evaluated the correlation between HbA1c and two indicators of glycemic control: fasting blood glucose (FBG) and postprandial blood glucose (PPBG).

Results: Both FBG and PPBG showed a significant positive correlation with HbA1c. However, PPBG had a stronger correlation with HbA1c than FBG. The Spearman’s correlation coefficient (r) was 0.610 (p<0.05) for FBG and HbA1c and 0.683 (p<0.05) for PPBG and HbA1c.

Conclusions: PPBG was a better predictor of HbA1c than FBG. PPBG may be an alternative marker of HbA1c for the management and monitoring of diabetes mellitus.

Downloads

Download data is not yet available.

References

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis of Burden. Study 2010. J Lancet. 2012;380:2095-128.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(1):S62-7.

Reusch JE. Diabetes, microvascular complications, and cardiovascular complications: What is it about glucose? J Clin Invest. 2003 Oct;112(7):986-8. doi: 10.1172/JCI19902. PMID: 14523035; PMCID: PMC198532

Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013 Jan;93(1):137-88. doi: 10.1152/physrev.00045.2011. PMID: 23303908.

Gallagher EJ, Le Roith D, Bloomgarden Z. Review of hemoglobin A(1c) in the management of diabetes. J Diabetes. 2009 Mar;1(1):9-17. doi: 10.1111/j.1753-0407.2009.00009.x. PMID: 20923515

Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther. 2008 Nov;88(11):1322-35. doi: 10.2522/ptj.20080008. PMID: 18801863; PMCID: PMC2579903

Shrestha L, Jha B, Yadav B, Sharma S. Correlation between fasting blood glucose, postprandial blood glucose and glycated hemoglobin in non-insulin treated type 2 diabetic subjects. Sunsari Techn Coll J. 2012;1(1):18-21.

Feingold KR. Capsule commentary on Radin, pitfalls in hemoglobin A1c measurement: when results may be misleading. J Gen Internal Med. 2014 Feb;29(2):363. doi: 10.1007/s11606-013-2632-9. PMID: 24065382; PMCID: PMC3912282

Radin MS. Pitfalls in hemoglobin A1c measurement: When results may be misleading. J Gen Intern Med. 2014 Feb;29(2):388-94. doi: 10.1007/ s11606-013-2595-x. PMID: 24002631; PMCID: PMC3912281

Published

07-04-2024

How to Cite

KUMAR, P., A. N. NAGDEOTE, P. GUPTA, and A. N. JADHAO. “A CORRELATION STUDY OF BLOOD HBA1C WITH FASTING AND POSTPRANDIAL BLOOD GLUCOSE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 17, no. 4, Apr. 2024, pp. 20-22, doi:10.22159/ajpcr.2024.v17i4.49660.

Issue

Section

Original Article(s)