PREVALENCE OF ANEMIA AND ITS ASSOCIATION WITH BODY MASS INDEX AND PLASMA PROTEIN IN MEDICAL STUDENTS OF KOLHAN REGION OF JHARKHAND – A CROSSSECTIONAL STUDY
DOI:
https://doi.org/10.22159/ajpcr.2024.v17i4.49666Keywords:
Haemoglobin, Plasma Protein, public health, nutrition, AdolescentAbstract
Objectives: Anemia is one of the major public health concerns affecting almost 30% of the global population. Past studies have indicated that anemia is linked to lower body mass index (BMI) and plasma protein levels. This study aims to determine the prevalence of anemia among medical students and also to investigate its association with BMI and plasma proteins.
Methods: A cross-sectional study of 177 medical and paramedical students aged 18–21 years was done at MGM Medical College in Jamshedpur from September 2018 to July 2019. A Transasia EM200 automated chemical analyzer was used to identify plasma protein using the biuret approach. HemoCOR-D (cyanmethemoglobin) was quantified by a colorimetric instrument. A colorimetric apparatus measured hemoglobin (Hb) with HemoCOR-D (cyanmethemoglobin).
Results: There are a total of 177 pupils. The study included 48% (n=85) females and 52% (n=92) males. Males had a mean age of 20.03± 0.99 years while females had a mean age of 20.16±0.937 years. Males had greater Hb levels and protein levels than females, with averages of 13.61 ± 1.43 and 7.77± 0.93, respectively. Males had a frequency of anemia of 15.4%, while females had a prevalence of 70.9%. The researchers discovered a statistically significant link between anemic and non-anemic girls’ plasma protein levels (p=0.07), protein intake and plasma protein (p=0.048), and BMI and Hb (p=0.022).
Conclusions: A significant association was found between daily protein intakes with plasma protein. The association between BMI and hemoglobin was also found significant.
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References
WHO. Anaemia in Women and Children; 2021. Available from: https:// www.who.int/data/gho/data/themes/topics/anaemia_in_women_and_ children [Last accessed on 2023 Jan 06].
Cappellini MD, Motta I. Anemia in clinical practice-definition and classification: Does hemoglobin change with aging? Semin Hematol. 2015 Oct 1;52(4):261-9. doi: 10.1053/j.seminhematol.2015.07.006, PMID 26404438
Ugwuja EI, Ogbonnaya LU, Obuna AJ, Awelegbe F, Uro-Chukwu H. Anaemia in relation to body mass index (BMI) and socio-demographic characteristics in adult Nigerians in Ebonyi State. J Clin Diagn Res. 2015;9(1):LC04-7. doi: 10.7860/JCDR/2015/9811.5485, PMID 25738011
Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ. Iron deficiency anaemia: Pathophysiology, assessment, practical management. BMJ Open Gastroenterol. 2022;9(1):e000759. doi: 10.1136/bmjgast-2021-000759, PMID 34996762
Alquaiz AM, Gad Mohamed A, Khoja TA, Alsharif A, Shaikh SA, Al Mane H, et al. Prevalence of anemia and associated factors in child bearing age women in Riyadh, Saudi Arabia. J Nutr Metab. 2013;2013:636585. doi: 10.1155/2013/636585, PMID 24205435
Balarajan Y, Ramakrishnan U, Ozaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123-35. doi: 10.1016/S0140- 6736(10)62304-5, PMID 21813172
Ghadiri-Anari A, Nazemian N, Vahedian-Ardakani HA. Association of body mass index with hemoglobin concentration and iron parameters in Iranian population. ISRN Hematol. 2014;2014:525312.
Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low-and middle-income countries. Ann N Y Acad Sci. 2019;1450(1):15-31. doi: 10.1111/nyas.14092, PMID 31008520
Kordas K, Fonseca Centeno ZY, Pachón H, Jimenez Soto AZ. Being overweight or obese is associated with lower prevalence of anemia among Colombian women of reproductive age. J Nutr. 2013;143(2):175-81. doi: 10.3945/jn.112.167767, PMID 23236023
Shattnawi KK, Alomari MA, Al-Sheyab N, Bani Salameh A. The relationship between plasma ferritin levels and body mass index among adolescents. Sci Rep. 2018;8(1):15307. doi: 10.1038/s41598-018- 33534-4, PMID 30333502
Khan A, Khan WM, Ayub M, Humayun M, Haroon M. Ferritin is a marker of inflammation rather than iron deficiency in overweight and obese people. J Obes. 2016;2016:1937320. doi: 10.1155/2016/1937320, PMID 28116148
Huang YF, Tok TS, Lu CL, Ko HC, Chen MY, Chen SC. Relationship between being overweight and iron deficiency in adolescents. Pediatr Neonatol. 2015;56(6):386-92. doi: 10.1016/j.pedneo.2015.02.003, PMID 25987352
Jeon YJ, Jung IA, Kim SH, Cho WK, Jeong SH, Cho KS, et al. Serum ferritin level is higher in male adolescents with obesity: Results from the Korean National Health and Nutrition Examination survey 2010. Ann Pediatr Endocrinol Metab. 2013;18(3):141-7. doi: 10.6065/ apem.2013.18.3.141, PMID 24904868
Sharif M, Madani M, Tabatabaie F. Comparative evaluation of iron deficiency among obese and non-obese children. Iran J Ped Hematol Oncol. 2014;4(4):160-6. PMID 25598956
Jeong J, Cho Y, Cho IY, Ahn J. Association between obesity and anemia in a nationally representative sample of South Korean adolescents: A cross-sectional study. Healthcare (Basel). 2022;10(6):1055. doi: 10.3390/healthcare10061055, PMID 35742105
Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164-74. PMID 24778671
Em 200. Transasia Bio-medicals; 2018. Available from: https:// transasia.co.in/instrument/clinical-chemistry/em-200/7 [Last accessed on 2023 Sep 20].
Cappellini MD, Musallam KM, Taher AT. Iron deficiency anaemia revisited. J Intern Med. 2020;287(2):153-70. doi: 10.1111/joim.13004, PMID 31665543
National Family Health Survey (NFHS-4), Version: 2015-16, India; 2017. p. 1-634. Available from: https://rchiips.org/nfhs/nfhs-4reports/ india.pdf
Choudhary N, Goyal MK, Sahay A, Vimal K, Setua KC. A comparative study of plasma protein and hemoglobin in 18-21 years age group students of MGM Medical College, Jamshedpur, Jharkhand. Int J Med Res Prof. 2019;5(6):63-6. doi: 10.21276/ijmrp.2019.5.6.016
Khan UH, Asif E, Hassan SA, Zohra RR, Hanif E. Prevalence of nutritional anaemia with association of body mass index among Karachi University students, Pakistans. J Pak Med Assoc. 2019;71:55-8. doi: 10.47391/JPMA.470
Siddharam SM, Venketesh GM, Thejeshwari HL. A study of anemia among adolescent girls in rural area of Hassan district, Karnataka, South India. Int J Biol Med Res. 2011;2(4):922-4.
Thamban V, Venkatappa KG, Swarnalatha PK, Sparshadeep EM. Anemia in relation to body mass index among female students of North Kerala: A pilot study. Int J Res Med Sci. 2018;6(11):3607-10. doi: 10.18203/2320-6012.ijrms20184416
Sinha AK, Singh Karki GM, Karna KK. Prevalence of anemia amongst adolescents in Biratnagar, Morang Dist. Nepal. Int J Pharm Biol Arch. 2012;3(5):1077-81.
Wenzel BJ, Stults HB, Mayer J. Hypoferremia in obese adolescents. Lancet. 1962;18:2(7251):327-8.
Shill KB, Karmakar P, Kibria MG, Das A, Rahman MA, Hossain MS, et al. Prevalence of iron-deficiency anaemia among university students in Noakhali region, Bangladesh. J Health Popul Nutr. 2014;32(1):103-10. PMID 24847599
Kaner G, Pekcan G, Pamuk G, Pamuk BÖ, Amoutzopoulos B. Is iron deficiency related with increased body weight? A cross-sectional study. Prog Nutr. 2016;18:102-10.
Verma A, Rawal VS, Kedia G, Kumar D, Chauhan J. Factors influencing anaemia among girls of school going age (6-18 years) from the slums of Ahmedabad city. Ind J Community Med. 2004;29:25-6.
Hsaini A, Aboussaleh Y, Bikri S, Ahami A. Association between BMI and iron status among diabetic patients in Oujda-ANGAD-MOROCCO. Curr Res Nutr Food Sci. 2020;8(2):416-23. doi: 10.12944/ CRNFSJ.8.2.07
Yanoff LB, Menzie CM, Denkinger B, Sebring NG, McHugh T, Remaley AT, et al. Inflammation and Iron deficiency in the hypoferremia of obesity. Int J Obes (Lond). 2007;31(9):1412-9. doi: 10.1038/ sj.ijo.0803625, PMID 17438557
Oliveira F, Rocha S, Fernandes R. Iron metabolism: From health to disease. J Clin Lab Anal. 2014;28(3):210-8. doi: 10.1002/jcla.21668, PMID 24478115
Andrews NC. Iron metabolism: Iron deficiency and iron overload. Annu Rev Genomics Hum Genet. 2000;1:75-98. doi: 10.1146/annurev. genom.1.1.75, PMID 11701625
Ghadimi R, Esmaili H, Kheirkhah D, Tamaddoni A. Is childhood obesity associated with iron deficiency anemia? Caspian J Pediatr. 2015;1(2):65-72.
Lecube A, Carrera A, Losada E, Hernández C, Simó R, Mesa J. Iron deficiency in obese postmenopausal women. Obesity (Silver Spring). 2006;14(10):1724-30
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