DEVELOPMENT AND OPTIMIZATION OF RAFT-FORMING FORMULATION OF H2BLOCKERS
DOI:
https://doi.org/10.22159/ajpcr.2024.v17i4.49774Keywords:
In situ gel, Nizatidine, Raft, Controlled releaseAbstract
Objective: The present research work is focused to develop in situ raft gel of Nizatidine. sodium alginate (SA) is one of the critical components for the development in situ raft system.
Methods: The formulation was prepared using polymers such as SA and gellan gum. The formulations were subjected to evaluation characteristics such as pH, in vitro gelling capacity, viscosity, gel strength, and in vitro release studies.
Results: The pH of all the prepared batches was found in the range of 6.4–7.2 for S1–S9, and 6.3–7.2 for G1–G9. S1–S9 formulations showed viscosity in the range of 253.7–400.9 cps, and G1–G9 formulations showed viscosity in the range of 253.4–399.8 cps. Formulation S6 containing SA and G6 containing gellan gum gave the highest drug content of 99.58% and 99.5%, respectively. The highest gel strength 4.6 is exhibited by S6 and G6 formulations. Formulation S6 containing SA gave the highest drug release of 95.62% and also showed sustained and controlled release for up to 12 h.
Conclusion: Gastric raft formulation is a better choice for drugs such as Nizatidine which enhances the drug release for a prolonged time by remaining buoyant in the stomach for more than 12 h.
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Srinivas L, Sagar S. Design, optimization, and evaluation of raft forming gastro retentive drug delivery system of lafutidine usingbox-behnken design. Int J Appl Pharm. 2022 Jan 1;14(1):266-74.
Patel DM, Patel DG, Patel CN. Formulation and optimization of raft forming chewable tablet containing lafutidine. Int J Pharm Sci Drug Res. 2015;7:229-34.
Green BJ, Guymon CA. Modification of mechanical properties and resolution of printed stereolithographic objects through RAFT agent incorporation. Addit Manuf. 2019;27:20-31.
Prajapati ST, Mehta AP, Modhia IP, Patel CN. Formulation and optimisation of raft-forming chewable tablets containing H2 antagonist. Int J Pharm Investig. 2012;2(4):176-82. doi: 10.4103/2230- 973X.106988, PMID 23580933
Mohite N, Salunkhe P, Shinde C, Chavan S. Isolation and characterization of polymer from tamarind seed: An emerging excipient for pharmaceutical use. Int J Curr Adv Res. 2019;8:19024-7.
Pashikanti S, Jyothsna B. Formulation and evaluation of floating in situ gel of ciprofloxacin. Int J Appl Pharm. 2019 Jan 1;11(1):198-204. doi: 10.22159/ijap.2019v11i1.28603
Sagar S, Pramodini GN. Formulation development and characterization of lafutidine raft system. Int J Pharm Pharm Sci. 2023 Apr 1;15:8-15. doi: 10.22159/ijpps.2023v15i4.47068
AQ1 Panda S, Madhusrota P, Sethi G. Raft forming system-A novel approach for improving gastric retention.
Borade AU, Shah K, Kale SN, Katyarmal AD, Gajbhiye SS, Kolhe NS. Research on natural polymer in execution of raft forming gastro-retentive drug delivery system. Int J Health Sci. 2022 May 27;6:11914-29. doi: 10.53730/ijhs.v6nS1.7966
Sagar S, Srinivas L. Development and evaluation of raft forming gastro retentive floating drug delivery system of nizatidine by design of experiment. Int J Appl Pharm. 2022 Mar 1;14(2):242-51.
Yadav V, Jadhav P, Salunkhe P, Nikam P, Matkar S. Formulation and evaluation of gastroretentive tablets of antiulcer drug. Asian J Pharm Clin Res. 2016 Nov;9(6):48-52. doi: 10.22159/ajpcr.2016.v9i6.10360
Shekhar M, Pandav S. Raft forming gastroretentive drug delivery system: A novel approach. Int J Creat Res Thoughts. 2020;8:.
Niranjanbhai BD, Mahendrakumar VN, Surendran CS, Viral HS, Upadhyay UM. Advances in GRDDS: Raft forming system a review introduction. J Drug Deliv Ther. 2012;2(5):123-8.
Patel R, Vaishnav G. Raft forming system-gastroretentive drug delivery system. Int J Adv Eng Manage Sci. 2020;6(12):515-9. doi: 10.22161/ ijaems.612.5
Sanjay KM, Gupta MK. Characterization and evaluation of nizatidine floating microspheres based drug delivery system for anti-ulcer activity. Int J Pharm Sci Res. 2019;10(10):4557-67.
Darwish MK, Abu El-Enin AS, Mohammed KH. Formulation, optimization, and evaluation of raft-forming formulations containing nizatidine. Drug Dev Ind Pharm. 2019 Apr;45(4):651-63. doi: 10.1080/03639045.2019.1569033, PMID 30638411
Teaima M, Abdelmonem R, Saady M, El-Nabarawi M, Shoman NA. Comprehensive overview on recent updates of gastroretentive raft-forming systems. Int J Appl Pharm. 2022;14(3):40-8. doi: 10.22159/ ijap.2022v14i3.44098
Dawood NM, Abdal-hammid SN, Hussien AA. Formulation and characterization of lafutidine nanosuspension for oral drug delivery system. Int J Appl Pharm. 2018;10(2):20-30. doi: 10.22159/ ijap.2018v10i2.23075
Abouelatta SM, Aboelwafa AA, El-Gazayerly ON. Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug. Drug Deliv. 2018 Nov;25(1):1161-74. doi: 10.1080/10717544.2018.1474969, PMID 29792353
Chaturvedi P, Soni PK, Paswan SK. Designing and development of gastroretentive mucoadhesive microspheres of cefixime trihydrate using spray dryer. Int J Appl Pharm. 2023 Mar 1;15(2):185-93. doi: 10.22159/ijap.2023v15i2.45399
Saini S, Bhardwaj BY, Chhabra J, Kumar M, Pahwa R. In vivo monitoring strategies for evaluation of floating drug delivery systems. Int J Appl Pharm. 2022;14:28-33. doi: 10.22159/ijap.2022v14i6.45906
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