THE PATTERN OF RISING AND FALLING OF SERUM CK-MB IN PATIENTS SUFFERING FROM MYOCARDIAL INFARCTION
DOI:
https://doi.org/10.22159/ajpcr.2024v17i11.51217Keywords:
Myocardial infarction, Isoenzymes, Creatine kinase MB, CK-MMAbstract
Objectives: Isoenzymes in the blood are important diagnostic and prognostic biomarkers in medical sciences for various cardiac diseases, that is, myocardial infarctions. Creatine kinase (CK)-MB is an important Isoenzyme secret when the destruction of cardiac muscle cells takes place.
Methods: A total of 196 myocardial infarction patients and 104 controls were studied in the cardiology department of Hamidia Hospital, Bhopal. Initial elevation of CK-MB occurs after 6 h mean time to peak elevation was 8–24 h and the time to return to the baseline was >48 h in male controls the mean CK-MB level was 19.34±2.83 IU/L and in female the means CK-MB level was 19.32±3.65 IU/L.
Result: The mean value of CK-MB at different time intervals in MI patients where 245.12±64.56 at 8–16 h, 230.50±44.88 IU/L at 17–24 h, 88.33±3.84 IU/L at 25–32 h, 74.50±38.19 IU/L at 33–40 h, and 50.88±2.32 IU/L at 41–48 h.
Conclusion: The pattern of rising and falling of CK-MB provided most valuable about the MI and its timely management. In conditions where reinfarction is suspected, CK-MB may be useful to classify a new event due to its shorter duration of elevation at detectable levels in plasma.
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References
Schlattner U, Tokarska-Schlattner M, Wallimann T. Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta. 2006;1762(2):164-80.
Hawkins RC, Tan HL. Comparison of the diagnostic utility of CK, CK-MB (activity and mass), troponin T and troponin I in patients with suspected acute myocardial infarction. Singapore Med J. 1999;40(11):680-4.
Aydin S, Aydin S. Irisin concentrations as a myocardial biomarker. In: Patel VB, Preedy VR, editors. Biomarkers in Cardiovascular Disease. Dordrecht: Springer; 2016. p. 489-504.
Khan IA, Wattanasuwan N. Role of biochemical markers in diagnosis of myocardial infarction. Int J Cardiol. 2005;104(2):238-40.
Wu AH, Apple FS, Gibler WB, Jesse RL, Warshaw MM, Valdes R Jr. National academy of clinical biochemistry standards of laboratory practice: Recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem. 1999;45(7):1104-21.
Keffer JH. Myocardial markers of injury. Evolution and insights. Am J Clin Pathol. 1996;105(3):305-20.
Beausire T, Faouzi M, Palmiere C, Fracasso T, Michaud K. High-sensitive cardiac troponin hs-TnT levels in sudden deaths related to atherosclerotic coronary artery disease. Forensic Sci Int. 2018;289:238-43.
Mondello C, Cardia L, Ventura-Spagnolo E. Immunohistochemical detection of early myocardial infarction: A systematic review. Int J Legal Med. 2017;131(2):411-21.
Aljakna A, Fracasso T, Sabatasso S. Molecular tissue changes in early myocardial ischemia: From pathophysiology to the identification of new diagnostic markers. Int J Legal Med. 2018;132(2):425-38.
Anderson PA, Malouf NN, Oakeley AE, Pagani ED, Allen PD. Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res. 1991 Nov;69(5):1226-33.
Lippi G, Von Meyer A, Cadamuro J, Simundic AM. Blood sample quality. Diagnosis (Berl). 2019 Mar 26;6(1):25-31.
Alan B, Storrow W. Brian Gibler: The role of cardiac markers in the emergency department. Clin Chim Acta. 1999;284(2):187-96.
Duma RJ, Seigel A. Serum creatinine phosphokinase in acute myocardial infarction: Diagnostic value. Arch Intern Med. 1965;115:443-51.
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