CLINICAL PROFILE, RISK FACTORS, AND PULMONARY FUNCTION TESTS IN PATIENTS OF OBSTRUCTIVE SLEEP APNEA
DOI:
https://doi.org/10.22159/ajpcr.2024v17i7.51818Keywords:
Obstructive sleep apnea, Risk Factors, Snoring, Pulmonary Function testAbstract
Objectives: The aim of this study was to analyze clinical profile, risk factors, and pulmonary function test (PFT) in patients with obstructive sleep apnea (OSA).
Methods: This was a prospective study undertaken in the department of pulmonary medicine of a tertiary care medical institute in which adult patients OSA were included on the basis of a predefined inclusion and exclusion criteria. Demographic details of patients were noted. Gender distribution, age distribution, clinical profile, and risk factors were studied. Severity of OSA was assessed by apnea hypopnea index (AHI). PFTs were done in all the cases.
Results: Out of 60 studied cases, there were 39 (65.00%) males and 21 (35.00%) females with a M: F ratio of 1: 0.53. The mean age of the studied cases was 51.58±11.14 years. The most common risk factor present in studied cases was increased neck circumference. Severity of OSA, as determined by AHI, was found to be mild, moderate, and severe in 34 (56.67%), 20 (33.33%), and 6 (10.00%) patients, respectively. Snoring that was bothersome to others was the most common presenting complaints in studied cases and was found in 52 (86.67%) cases. PFT was normal in 23 (38.33%) patients whereas obstructive as well as restrictive features were seen in 16 (26.67%) and 14 (23.33%) patients, respectively.
Conclusion: PFTs should be included during workup of patients with OSA and obstructive lung disease may coexist and cause an increase in mortality.
Downloads
References
Barletta P, Abreu AR, Ramos AR, Dib SI, Torre C, Chediak AD. Role of obstructive sleep apnea in cognitive impairment. Int J Head Neck Surg. 2019 Jul-Sep;10(3):57-61. doi: 10.5005/jp-journals-10001-1373, PMID: 34305353, PMCID: PMC8302067
Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008 Feb 15;5(2):144-53. doi: 10.1513/ pats.200707-114MG, PMID: 18250206, PMCID: PMC2628457
Trosman I, Trosman SJ. Cognitive and behavioral consequences of sleep disordered breathing in children. Med Sci (Basel). 2017 Dec 1;5(4):30. doi: 10.3390/medsci5040030, PMID: 29194375, PMCID: PMC5753659
Paschou SA, Bletsa E, Saltiki K, Kazakou P, Kantreva K, Katsaounou P, et al. Sleep apnea and cardiovascular risk in patients with prediabetes and type 2 diabetes. Nutrients. 2022 Nov 24;14(23):4989. doi: 10.3390/ nu14234989, PMID: 36501019, PMCID: PMC9741445
Bloch KE. Polysomnography: A systematic review. Technol Health Care. 1997 Oct;5(4):285-305. doi: 10.3233/THC-1997-5403, PMID: 9429270
Liang BM, Lam DC, Feng YL. Clinical applications of lung function tests: A revisit. Respirology. 2012;17(4):611-9. doi: 10.1111/j.1440- 1843.2012.02149.x, PMID: 22329710
Waters T. Alternative interventions for obstructive sleep apnea. Cleve Clin J Med. 2019 Sep;86(9);Suppl 1:34-41. doi: 10.3949/ccjm.86. s1.06, PMID: 31509502
Shivalkar B, Van de Heyning C, Kerremans M, Rinkevich D, Verbraecken J, De Backer W, et al. Obstructive sleep apnea syndrome: More insights on structural and functional cardiac alterations, and the effects of treatment with continuous positive airway pressure. J Am Coll Cardiol. 2006;47(7):1433-9. doi: 10.1016/j.jacc.2005.11.054, PMID: 16580533
Galvan T, Camuso J, Sullivan K, Kim S, White D, Redline S, et al. Association of estradiol with sleep apnea in depressed perimenopausal and postmenopausal women: A preliminary study. Menopause. 2017 Jan;24(1):112-7. doi: 10.1097/GME.0000000000000737, PMID: 27648659, PMCID: PMC5177515
Kapse V, Patel V, Mhaisekar D, Kulkarni M. Gender differences in clinical profile and risk factors for obstructive sleep apnea in a public health care setting. Int J Res Med Sci. 2019;7(7):2808-12. doi: 10.18203/2320-6012.ijrms20192924
Lin CM, Davidson TM, Ancoli-Israel S. Gender differences in obstructive sleep apnea and treatment implications. Sleep Med Rev. 2008;12(6):481-96. doi: 10.1016/j.smrv.2007.11.003, PMID: 18951050
Shepertycky MR, Banno K, Kryger MH. Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep. 2005;28(3):309-14. PMID: 16173651
Kareem O, Tanvir M, Bader GN. Prevalence of high risk obstructive sleep apnoea by Berlin questionnaire in patients with hypertension: Study from a tertiary care hospital. Sleep Sci Pract. 2020;4(1):15. doi: 10.1186/s41606-020-00052-0
Nair S, Paul T, Mehta AA, Haridas N, Kunoor A, Sudhakar N. Prevalence of overlap syndrome in patients with obstructive sleep apnea in a quaternary care center of Kerala. Indian J Public Health. 2022;66:S12-6. doi: 10.4103/ijph.ijph_1085_22, PMID: 36412466
Bouloukaki I, Fanaridis M, Stathakis G, Ermidou C, Kallergis E, Moniaki V, et al. Characteristics of patients with obstructive sleep apnea at high risk for cardiovascular disease. Medicina (Kaunas). 2021;57(11):1265. doi: 10.3390/medicina57111265, PMID: 34833483
Mitra AK, Bhuiyan AR, Jones EA. Association and risk factors for obstructive sleep apnea and cardiovascular diseases: A systematic review. Diseases. 2021;9(4):88. doi: 10.3390/diseases9040088, PMID: 34940026
Thompson C, Legault J, Moullec G, Baltzan M, Cross N, Dang-Vu TT, et al. A portrait of obstructive sleep apnea risk factors in 27,210 middle-aged and older adults in the Canadian longitudinal study on aging. Sci Rep. 2022;12(1):5127. doi: 10.1038/s41598-022-08164- 6, PMID: 35332170
Qian Y, Dharmage SC, Hamilton GS, Lodge CJ, Lowe AJ, Zhang J, et al. Longitudinal risk factors for obstructive sleep apnea: A systematic review. Sleep Med Rev. 2023;71:101838. doi: 10.1016/j. smrv.2023.101838, PMID: 37639973
Mehfooz N, Siraj F, Shabir A, Mantoo S, Shah TH, Hafiz U, et al. Spirometric abnormalities in patients with sleep-related breathing disorders. J Fam Med Prim Care. 2021 Feb;10(2):1009-14. doi: 10.4103/ jfmpc.jfmpc_1018_20, PMID: 34041113, PMCID: PMC8138423
Haponik EF, Bleecker ER, Allen RP, Smith PL, Kaplan J. Abnormal inspiratory flow-volume curves in patients with sleep-disordered breathing. Am Rev Respir Dis. 1981;124(5):571-4. doi: 10.1164/ arrd.1981.124.5.571, PMID: 7305112
Abdeyrim A, Zhang Y, Li N, Zhao M, Wang Y, Yao X, et al. Impact of obstructive sleep apnea on lung volumes and mechanical properties of the respiratory system in overweight and obese individuals. BMC Pulm Med. 2015;15:76. doi: 10.1186/s12890-015-0063-6, PMID: 26209328
Published
How to Cite
Issue
Section
Copyright (c) 2024 Sowmya Guguloth, Mounika A, Bhanurekha B
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.