TO STUDY THE SEROPREVALENCE OF BRUCELLOSIS IN CASES OF ACUTE UNDIFFERENTIATED FEBRILE ILLNESS AT A TERTIARY CARE HOSPITAL, AMRITSAR
DOI:
https://doi.org/10.22159/ajpcr.2024v17i12.52967Keywords:
Acute febrile illness, Fever, ZoonoticAbstract
Objective: This study sought to determine the seroprevalence of human brucellosis in patients presenting with acute undifferentiated illness at a tertiary care hospital.
Methods: The cross-sectional investigation was done on patients presenting to the outpatient or inpatient Department of Medicine at Government Medical College, Amritsar during the study period, regardless of age group, with an acute undifferentiated febrile illness. A 5 mL of whole blood was extracted in a plain vacutainer from suspected patients and enzyme-linked immunosorbent assay (ELISA) was performed.
Results: Out of 100 samples,11 came out positive by ELISA. Four females and seven males tested positive. Three (27.27%) of the 11 samples had immunoglobulin (Ig)G anti-bodies, whereas 8 (72.72%) samples had IgM anti-bodies.
Conclusion: Brucellosis is a serious zoonotic illness with consequences for public health. Efforts should be focused on creating and executing efficient animal vaccination programs, as well as on better diagnostic techniques.
Downloads
References
Patil DP, Ajantha GS, Shubhada C, Jain PA, Kalabhavi A, Shetty PC, et al. Trend of human brucellosis over a decade at tertiary care centre in North Karnataka. Indian J Med Microbiol. 2016 Oct 1;34(4):427-32. doi: 10.4103/0255-0857.195372, PMID: 27934819
Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol. 2007 Jul 1;25(3):188-202. doi: 10.4103/0255-0857.34758, PMID: 17901634
Doganay M, Aygen B. Human brucellosis: An overview. Int J Infect Dis. 2003 Sep 1;7(3):173-82. doi: 10.1016/S1201-9712(03)90049-X
Pathak AD, Dubal ZB, Doijad S, Raorane A, Rodrigues S, Naik R, et al. Human brucellosis among pyrexia of unknown origin cases and occupationally exposed individuals in Goa Region, India. Emerg Health Threats J. 2014 Jan 1;7(1):23846. doi: 10.3402/ehtj.v7.23846, PMID: 24762925
Rubio M, Barrio B, Díaz R. Usefulness of rose Bengal, Coombs and counter-immunoelectrophoresis for the diagnosis of human brucellosis cases with negative seroagglutination. Enferm Infecc Microbiol Clin. 2001 Oct 1;19(8):406-7. doi: 10.1016/s0213-005x(01)72675-4, PMID: 11602144
Baily GG, Krahn JB, Drasar BS, Stoker NG. Detection of Brucella melitensis and Brucella abortus by DNA amplification. J Trop Med Hyg. 1992 Aug 1;95(4):271-5. PMID: 1495123
Wharton M, Chorba TL, Vogt RL, Morse DL, Buehler JW. Case definitions for public health surveillance. MMWR Recomm Rep. 1990 Oct 19;39(RR-13):1-43. PMID: 2122225
Mantur BG, Amarnath SK. Brucellosis in India-a review. J Biosci. 2008 Nov;33(4):539-47. doi: 10.1007/s12038-008-0072-1, PMID: 19208979
Aghamohammad S, Rastin M, Mostafavi E, Anaraki AH, Rahravani M, Sadaf RA, et al. Determination of seroprevalence of brucellosis in livestock and high-risk population in Kurdistan, Western Iran. Comp Immunol Microbiol Infect Dis. 2023;93:101942. doi: 10.1016/j. cimid.2022.101942, PMID: 36603240
Shome R, Kalleshamurthy T, Shankaranarayana PB, Giribattanvar P, Chandrashekar N, Mohandoss N, et al. Prevalence and risk factors of brucellosis among veterinary health care professionals. Pathog Glob Health. 2017 Jul 4;111(5):234-9. doi: 10.1080/20477724.2017.1345366, PMID: 28689480
Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: A retrospective evaluation and review of the literature. Int J Infect Dis. 2010 Jun 1;14(6):e469-78. doi: 10.1016/j.ijid.2009.06.031, PMID: 19910232
Madzingira O, Fasina FO, Kalinda C, Van Heerden H. Seroprevalence of brucellosis among clinically suspected human cases presenting at health facilities in Namibia from 2012 to 2017. Biomed Environ Sci. 2021 Mar 20;34(3):232-5.
Handa R, Singh S, Singh N, Wali JP. Brucellosis in North India: Results of a prospective study. J Commun Dis. 1998 Jun 1;30(2):85-7. PMID: 9914673
Shukla JL, Husain AA, Lyngdoh SA, Nonglang FP, Sahai N, Gogoi M, et al. Seroepidemiological study of human brucellosis in the Northeast region of Meghalaya, India. J Fam Med Prim Care. 2022 Sep 1;11(9):5176-86. doi: 10.4103/jfmpc.jfmpc_1705_21, PMID: 36505523
Published
How to Cite
Issue
Section
Copyright (c) 2024 SUNIDHI SOHAL, KANWARDEEP SINGH, SHAILPREET KAUR SIDHU, SATPAL ALOONA, LOVEENA OBEROI, MANINDER KAUR, NEELU NAGPAL
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
