DESIGN AND IN-VITRO EVALUATION OF CONTROLLED RELEASE TRI-LAYER VENLAFAXINE HCL TRANSDERMAL PATCH
Abstract
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Objectives: The purpose of this study was to design a suitable transdermal therapeutic system for venlafaxine hydrochloride (VFH) with the objective
to prolong the release to be used for controlled release drug delivery.
Methods: Transdermal patches of VFH with a hydroxypropyl methylcellulose drug reservoir were prepared by the solvent evaporation technique.
In this investigation, the Eudragit RSPO membrane in different concentrations was cast to achieve controlled release of the drug. The absence of
physiochemical interactions between VFH and the polymers was confirmed by Fourier transform infrared spectroscopy. The physicochemical
parameters and in-vitro drug release studies of formulations were performed and data of optimized formulation were fitted to various kinetic models.
Results: The results indicated that suitable tri-layered transdermal patches of VFH with controlled drug release could be prepared. All the formulations
exhibited satisfactory physicochemical characteristics. Among the formulations prepared, formulation F2 showed optimized controlled release for
24 hrs (96.42%) with the flux of 28.28 μg/cm2/hr and permeability coefficient of 1.1315×10−3 cm/hr. Drug release from optimized patch followed
Korsmeyer-Peppas model and was mediated by Fickian diffusion mechanism.
Conclusion: Hence, the development of adhesive type tri-layered transdermal patches for VFH might be a promising one to control the drug release
for 24 hrs with reduced side-effects.
Keywords: Venlafaxine hydrochloride, Tri-layered transdermal patch, Plasticizer, In-vitro drug release study, In-vitro permeation study.
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