COMPARISON OF AMLODIPINE TRANSDERMAL PATCHES USING HYDROXYPROPYLMETHYLCELLULOSE AND CHITOSAN

Abstract

Objective: The aim of our study was to design and evaluate Amlodipine transdermal patches & compare these patches using polymers such as hydroxypropylmethylcellulose and chitosan. Methods: Amlodipine were prepared by solvent casting method by using polymers like  hydroxypropylmethylcellulose and chitosan in different proportions(1percent, 1.5percent, 2percent and 2.5percent). Plasticizers used were propylene glycol and  dibutylpthlate.The transdermal patches were evaluated for their physicochemical properties like folding endurance, thickness, percentage moisture loss, percentage moisture absorption, drug content and water vapour transmission rate. Result: The diffusion studies were performed by using franz diffusion cell.Formulation H7(2percent HPMC) and C7(2percent CS) with DBP as plasticizer showed a maximum release of 99percent in 24 hours Conclusion: Out of these two formulations the use of chitosan in a transdermal patches seems to be attractive due to its biocompatibility and biodegradability as well as opportunities to modify the charge density and molecular chain length of the chitosan in the membrane without changing its status as a natural biopolymer. Thus the knowledge on the use of chitosan to control drug release in transdermal delivery systems might be applicable to other transdermal drug delivery system as well.

Keywords: Transdermal, hydroxypropylmethylcellulose, Chitosan, Amlodipine