PHARMACOLOGICAL SCREENING FOR POTENCY OF ANTIOBESITY ON FIVE PLANTS BASED ON ETHNOPHARMACOLOGICAL USE

Authors

  • Finna Setiawan
  • Ketut Adnyana I
  • Elin Yulinah Sukandar
  • Sukrasno
  • Ari Yuniarto Bandung Institute of Technology
  • Resny Pebritrinasari

Abstract

ABSTRACT
Objective: The objective of this research was to screening potency of anti-obesity effect and antioxidant activity from Sapindus rarak Pulp., Punica
granatum Leaves, Jasminllum sambac Flos., Tamarindus indica Pulp., and Senna alexandrina Leaves.
Methods: This study was performed through in-vitro method to determine the potency of anti-obesity, such as its ability to inhibit pancreatic lipase
activity and radical-scavenging activity against free radicals like 1,1-diphenyl-2-picrylhydrazyl to determine the potency of these plants as antioxidant.
Results: The 50% inhibitory concentration of pancreatic lipase activity inhibitory and antioxidant activity consecutively, P. granatum Leaves
(20.64 ppm; 77.89 ppm), J. sambac Flos. (53.46 ppm; 127.95 ppm), T. indica Pulp. (62.02 ppm; 159.16 ppm), S. alexandrina Leaves (94.69 ppm;
142.28 ppm), and S. rarak Pulp. (796.32 ppm; 147.56 ppm).
Conclusion: P. granatum Leaves showed the best potency of anti-obesity compared to other plants based on its ability to inhibit pancreatic lipase
activity and antioxidant activity.
Keywords: Anti-obesity, Pancreatic lipase activity, Antioxidant.

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Author Biography

Ari Yuniarto, Bandung Institute of Technology

School of Pharmacy and Rank of 125 in Southeast Asia (2014)

References

REFERENCES

Han LK, Zheng YN, Yoshikawa M, Okuda H, Kimura Y. Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement Altern Med 2005;5:9.

Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes (Lond) 2013;37:333-40.

Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: Considerations and implications. Int J Obes (Lond) 2012;36(3):387-96.

Patel RM, Patel NJ. In vitro antioxidant activity of coumarin compounds by DPPH, super oxide and nitric oxide free radical scavenging methods. J Adv Pharm Edu Res 2011;1:52-68.

Han LK, Kimura Y, Okuda H. Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet. Int J Obes 1999;23(2):174‑9.

Chaturvedi S, Joshi A, Dubey BK. Pharmacognostical, phytochemical, and cardioprotective activity of Tamarindus indica Linn. Bark. Int J Pharm Sci Res 2011;2(11):3019-27.

Pradono DI, Darusman LK, Susanti A. Pancreatic lipase in vitro inhibition by aqueous and ethanol extract of asam jawa leaves (Tamarindus indica) and kunci pepet rhizome (Kaempferiae rotundae). J Nat Indones 2011;13(2):146-54.

Rani N, Vasudeva N, Sharma SK. Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill. BMC Complement Altern Med 2012;12:145.

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114(12):1752-61.

Lee H, Lee YJ, Choi H, Ko EH, Kim JW. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. J Biol Chem 2009;284(16):10601-9.

Higuchi M, Dusting GJ, Peshavariya H, Jiang F, Hsiao ST, Chan EC, et al. Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead box O1 mediated upregulation of antioxidant enzymes. Stem Cells Dev 2013;22(6):878‑88.

Sfar S, Boussoffara R, Sfar MT, Kerkeni A. Antioxidant enzymes activities in obese Tunisian children. Nutr J 2013;12:18.

Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. Obesity-associated oxidative stress: Strategies finalized to improve redox state. Int J Mol Sci 2013;14(5):10497-538.

Published

01-07-2015

How to Cite

Setiawan, F., K. Adnyana I, E. Yulinah Sukandar, Sukrasno, A. Yuniarto, and R. Pebritrinasari. “PHARMACOLOGICAL SCREENING FOR POTENCY OF ANTIOBESITY ON FIVE PLANTS BASED ON ETHNOPHARMACOLOGICAL USE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 8, no. 4, July 2015, pp. 299-01, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/6786.

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