FORMULATION AND EVALUATION OF VALSARTAN FAST DISINTEGRATING TABLETS BY VACUUM DRYING TECHNIQUE
Abstract
ABSTRACT
Objective: The main objective present research work an attempt has been made to prepare fast dissolving tablets of Valsartan by using vacuum
drying technique. Camphor, Urea and Menthol are used as a sublimating agent. Valsartan is an oral antihypertensive agent, with problems of variable
bioavailability and bioequivalence related to its poor water solubility. Valsartan is an angiotensin II type 1 receptor antagonist indicated in the
treatment of hypertension.
Methods: The prepared tablets Valsartan fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability,
disintegration time, drug content, water absorption ratio, wetting time, in- vitro drug release, FTIR, DSC studies and short term stability studies. The
blend was examined for the pre-compressional and post-compressional parameter.
Results and Discussions: The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing
property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. Based on the invitro
disintegration
time and dissolution studies formulations
SC2 and
SC3
were
found
to
be promising
and
showed
a
disintegration
time of 24
sec
and
16 sec
respectively.
Formulation
SC3 containing
camphor showed
highest
drug release
99.4% within
10 min.
IR spectral
analysis
and
DSC study
showed
that
there
was
no drug interaction
with formulation
additives
of
the
tablet as
there
is no
variation
and shift in
the position of
characteristic
absorption
bands it can
be
justified
there
is no interaction
between
drug and polymer.
Short term
stability studies
on the formulations
indicated
that
there
are
no significant change in hardness,
friability,
drug content
and in-vitro
drug release
(p<0.05).
Conclusion: The results concluded that fast dissolving tablets of Valsartan showing enhanced dissolution may lead to improved bioavailability
and effective therapy by using sublimation method.
Keywords: Fast dissolving tablet, Valsartan, Crospovidone, Camphor, Urea, Disintegration time.
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References
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