ACENOCOUMAROL OR WARFARIN: WHICH IS THE CLINICIAN'S ALLY?

Authors

  • Karthik Rao N
  • Navin Patil
  • A Avinash
  • Handattu Manjunatha Hande
  • Sushil Kiran Kunder
  • Raghavendra Rao

Abstract

ABSTRACT
Warfarin and acenocoumarol are commonly prescribed oral anticoagulant drugs that are used in the prevention and treatment of thromboembolic
disorders across the world. Although both these drugs act by a similar mechanism, there are significant differences between them, especially in terms
of their half-lives, and more importantly, in their variability in response pharmacogenetically. This case report highlights an instance wherein warfarin
proved to provide a much more stable anticoagulant cover, as compared to that provided by acenocoumarol.
Keywords: Thrombosis, Bleeding, Antiphospholipid antibody syndrome, Anticoagulant, International normalized ratio.

Downloads

Download data is not yet available.

References

REFERENCES

Undas A, Ciesla-Dul M, Zólcinski M, Tracz W. Switching from

acenocoumarol to warfarin in patients with unstable anticoagulation

and its effect on anticoagulation control. Pol Arch Med Wewn

;119(6):360-5.

Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G,

et al. Pharmacology and management of the vitamin K antagonists:

American College of Chest Physicians Evidence-Based Clinical

Practice Guidelines (8

Edition). Chest 2008;133 Suppl 6:160S-98.

Gurwitz JH, Avorn J, Ross-Degnan D, Choodnovskiy I, Ansell J. Aging

th

and the anticoagulant response to warfarin therapy. Ann Intern Med

;116(11):901-4.

Sconce EA, Khan TI, Wynne HA, Avery P, Monkhouse L, King BP,

et al. The impact of CYP2C9 and VKORC1 genetic polymorphism and

patient characteristics upon warfarin dose requirements: Proposal for a

new dosing regimen. Blood 2005;106(7):2329-33.

Beinema M, Brouwers JR, Schalekamp T, Wilffert B. Pharmacogenetic

differences between warfarin, acenocoumarol and phenprocoumon.

Thromb Haemost 2008;100(6):1052-7.

Barcellona D, Vannini ML, Fenu L, Balestrieri C, Marongiu F.

Warfarin or acenocoumarol: Which is better in the management of oral

anticoagulants? Thromb Haemost 1998;80(6):899-902.

Published

01-03-2016

How to Cite

Rao N, K., N. Patil, A. Avinash, H. M. Hande, S. K. Kunder, and R. Rao. “ACENOCOUMAROL OR WARFARIN: WHICH IS THE CLINICIAN’S ALLY?”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 4-5, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/9525.

Issue

Section

Case Study(s)

Most read articles by the same author(s)

<< < 1 2 3 4 > >>