FORMULATION AND EVALUATION OF TASTE MASKED ORAL SUSPENSION OF CEFUROXIME AXETIL USING HYDROXYPROPYL-BETA-CYCLODEXTRIN

Authors

  • Renju Prabhakaran Sance Laboratories Pvt Ltd, Kottayam, Kerala
  • Janakiraman K Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India-608002
  • Jyoti Harindran Department of Pharmaceutical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India

Abstract

ABSTRACT
Objective: Cefuroxime axetil is a prodrug of Cefuroxime, which is extremely bitter in taste, which reduces the patient compliance when taken as
oral suspension especially in pediatric population. The objective of this study was to mask the bitter taste of Cefuroxime axetil using Hydroxy propyl
betacyclodextrin [HP- Betacyclodextrin] by inclusion complexation method.
Methods: The complexation of Cefuroxime axetil and HP- Betacyclodextrin was carried out at 1:1, 1:2, 1:2.5 and 1:3 ratios respectively. The prepared
suspension was evaluated for various parameters like pH, viscosity, redispersibility, pourability, assay and invitro dissolution profile. A comparative
evaluation of the taste masking was carried out for the developed formulations and marketed product.
Results: All the formulations and the marketed product were meeting all the quality parameters. Formulations with 1:3 and 1:2.5 ratios showed
better taste masking compared to the marketed product and the formulation with 1:2.5 ratio shown to have better invitro dissolution pattern.
Conclusion: Considering the invitro dissolution profile and taste evaluation with marketed product, formulation with 1:2.5 ratio of Cefuroxime axetil
and HP- Betacyclodextrin was selected as the optimum formulation.
Keywords: Cefuroxime axetil, Taste masking, Betacyclodextrin, Inclusion complexation.

Downloads

Download data is not yet available.

Author Biographies

Renju Prabhakaran, Sance Laboratories Pvt Ltd, Kottayam, Kerala

Deputy Manager- FR&D

Janakiraman K, Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamilnadu, India-608002

Assoiate professor

References

REFERENCES

Vummaneni V, Nagpal D. Taste masking technologies: An overview and

recent updates. Int J Res Pharm Biomed Sci 2012;3(2):510-24.

Sharma S, Lewis S. Taste masking technologies: A review. Int J Pharm

Pharm Sci 2010;2(2):6-13.

Menjoje AR, Kulkarni MG. Pharmaceutical composition for improving

palatability of drugs and process for preparation thereof. U.S Patent

No. 7378109 B2 to Council of Scientific and Industrial Research; 2008.

Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral

pharmaceuticals: Recent developments and approaches. Drug Dev Ind

Pharm 2004;30(5):429-48.

Chatap VK. Review on taste masking methods of bitter drug.

Pharmainfo.net 2007;5.

Yuqian D, Zhai Y, Zhang J, Wu C, Luo C, Sun J, et al. Development

and evaluation of taste-masked dry suspension of cefuroxime axetil for

enhancement of oral bioavailability. Asian J Pharm Sci 2013;8:287-94.

Vinod J, Chenthilnathan A. Formulation development and evaluation of

taste masked cefuroxime axetil dry suspension. Pelagia Res Libr Pharm

Sin 2013;4(2):98-103.

Uzunovic A, Vranic E. Stability of cefuroxime axetil oral suspension

at different temperature storage conditions. Bosn J Basic Med Sci

;8(1):93-7.

Donn KH, James NC, Powell JR. Bioavailability of cefuroxime axetil

formulations. J Pharm Sci 1994;83(6):842-4.

Fernadez M, Garriz E. Coated particulate cefuroxime axetil

compositions. WO043638 to Glaxo Group Ltd.; 2003.

Khan AR, Kondawar KV, Gosavi AS. Pharmaceutical Formulation

WIPO Patent Application No. 043707 to Wokhardt Research Centre;

Nighute AB, Bhise SB. Preparation and evaluation of microcrystals of

cefuroxime axetil. Int J PharmTech Res 2009;1(3):682-94.

Birhade ST, Bankar VH, Gaikwad PD, Pawar SP. Preparation and

evaluation of cyclodextrin based binary systems for taste masking.

IJPSDR 2010;2(3):199-203.

Pateli AR, Vavia PR. Preparation and evaluation of taste masked

famotidine formulation using drug/β-cyclodextrin/polymer ternary

complexation approach. AAPS PharmSciTech 2008;9:2.

Rowe RC. Hand Book of Pharmaceutical Excipients. 5

ed. Washington,

DC: Pharmaceutical Press; 2006.

th

Szejtli J, Szente L. Elimination of bitter, disgusting tastes of drugs and

foods by cyclodextrins. Eur J Pharm Biopharm 2005;61(3):115-25.

Gould S, Scott RC. 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD):

A toxicology review. Food Chem Toxicol 2005;43(10):1451-9.

Michael B. James, James, Leonard G. Elliott. Pharmaceutical

composition comprising cefuroxime axetil. U.S. Patent No. 4865851 to

Glaxo Group Ltd.; 1989.

Gedam SS, Tapar KK, Borse MD, Ghuge RA. Taste masking and

characterization of diphenhydramine hydrochloride by Spray drying

technique. IJPRD 2005;1(12):03.

Published

01-03-2016

How to Cite

Prabhakaran, R., J. K, and J. Harindran. “FORMULATION AND EVALUATION OF TASTE MASKED ORAL SUSPENSION OF CEFUROXIME AXETIL USING HYDROXYPROPYL-BETA-CYCLODEXTRIN”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 90-92, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/9628.

Issue

Section

Original Article(s)

Most read articles by the same author(s)