DETERMINATION OF PHARMACOKINETIC PARAMETERS FOR ATROPA BELLADONA EXTRACT CONTAINING ATROPINE IN TABLET DOSAGE FORM
Abstract
ABSTRACT
Objective: The present work was to formulate oral herbal tablets of Atropa belladona extract and also with pure atropine, further to determine the
pharmacokinetic parameters and determine the dose frequency based on half-life.
Methods: After the quantification of the extract through high-performance thin layer chromatography, tablets were prepared with extract and
pure form of atropine through direct compression technique by varying the process and formulation parameters. The pre- and post-compression
parameters were evaluated for the formulated batches. In vivo studies using rabbit models of either sex were done and the various pharmacokinetic
parameters were reported.
Results: The pharmacokinetic data obtained for pure and extract showed no significant difference in C
Conclusion: According to the results the Atropa belladonna extract and pure atropine tablets gave a t
1/2
max
at t
max
of 2 hrs.
of 3 hrs, representing that one tablet (equivalent
to 0.021 mg of atropine) can be administered at every 3 hrs.
Keywords: Atropine, Atropa belladonna, Herbal, Pharmacokinetics, Tablets.
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