FORMULATION AND EVALUATION OF EFFERVESCENT GRANULES OF IBUPROFEN
DOI:
https://doi.org/10.22159/ijap.2019v11i6.34912Keywords:
Ibuprofen, Effervescent, Granules, Wet granulationAbstract
Objective: The object of this investigation was to formulate and evaluate effervescent granules of ibuprofen, to increase its dissolution rate to get rapid analgesic and antipyretic effects.
Methods: Five formulas (F1-F5) of effervescent ibuprofen granules were formulated by the wet granulation method. Croscarmellose sodium, powder of banana and other ingredients were used in the formulation of effervescent granules. Evaluation studies were carried out for all five formulas, these include: (compatibility study, flowability study, % of drug content, effervescent time and in vitro dissolution study).
Results: The results show that the formulated granules have good flow properties with suitable bulk density for the uniting dose. FTIR study shows that there is no drug interaction with other ingredients in the formula. All five formulas have effervescent time less than 3 min, F5 show the best drug release 99.1±1 and effervescent time about 80 sec.
Conclusion: Ibuprofen was successfully formulated and evaluated as effervescent granules by using a combination of croscarmellose sodium and banana powder.
Downloads
References
Aulton ME. Pharmaceutics: the science of dosage form design. 2nd ed. New York: Churchill Livingstone; 2002.
Diy ASM, Thom NY. Formulation and evaluation of metronidazole effervescent granules. Int J Pharm Sci Res 2018;9:2525-9.
Parikh, Dilip M. Effervescent granules. Handbook of pharmaceutical granulation technology. Edn 3. Informa Healthc; 2005. p. 365-84.
Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vitro bioavailability. Pharm Res 1995;12:413–20.
Lachmann L, Liberman H, Kanig J. The theory and practice of industrial pharmacy. Edn 3. Verghese Publishing House, Bombay; 1991. p. 320-1.
Bhosale AV, Hardikar SR, Patil N, Patel U, Sumbe Y, Jagtap R. Formulation and in vitro evaluation of microbially triggered ibuprofen. Int J PharmTech Res 2009;1:328-33.
S Patel, Natvarlal M Patel. Development of directly compressible co-processed excipient for dispersible tablets using 32 full factorial design. Int J Pharm Pharm Sci 2009;1:125-48.
Senthil P, Suresh Kumar CH, Narasimha Raju, S Mohideen. Formulation and evaluation of gastric oral floating tablet of glipzide. Int J Biol Pharm Res 2010;1:108-13.
Wells J. Pharmaceutical preformulation: the physicochemical properties of drug substances. In: Aulton M. The science of dosage form design by Michael. 2nd ed. Churchill livengstone; 2004. p. 133-4.
Kaerger S, Edge S, Price R. Influence of particle size and shape on flowability and compatibility of binary mixtures of paracetamol and microcrystalline cellulose. Eur J Pharm Sci 2004;22:173-9.
Sandhya S, Gowthami G, Vinod KR, VidyaSravanthi E, Saikumar P, Rao Knv, et al. Formulation and evaluation of herbal effervescent granules incorporated with limnophila indica extract for bacillary dysentery. Ann Bio Res 2012;3:63-72.
R Margret chandira, Debjit Bhowmik, Rahul Yadav, B Jayakar, K Sampath Kumar. Formulation and evaluation of the oral tablets ibuprofen. Pharma Innovation 2012;1:32-42.
Abolfazl Aslani, Fatemeh Fattahi. Formulation characterization and physicochemical evaluation of potassium citrate effervescent tablet. Adv Pharm Bull 2013;3:217–25.
Eter lakin. Infrared and Raman spectroscopy. 1st edition; 2011.
The United State Pharmacopeia (USP), 30, NF28, USA: The United State Pharmacopeia Convention Inc; 2010.
RB Saudagar. Formulation and characterization and evaluation of mouth dissolving tablet of lisinopril by using dehydrated banana powder as a natural polymer. WJIPR 2015;4:763-74.
Nayyar Parz, Pramod Kuma. FDA-Approved natural polymers for fast-dissolving tablets. J Pharm 2014;1-6. http://dx.doi.org/10.1155/2014/952970.
Shah SJ. Formulation and evaluation of mouth dissolving tablet of tramadol hydrochloride. AJPCR 2013;6:31-6.
J Ham, S Parthiban, A Vikneswari, GP Sentil kumar, T Tamiz Mani. Formulation and evaluation of orodispersible liquisolid compacts of meloxicam using banana powder as natural super disintigrentes. AJPRS 2015;3:25-38.
Gopinath E. Evaluation of musa acuminate fruit as a natural super disintegrant for tablet formulation. AJPCR 2018;11:167-71.
Hiola R, Tunadi R. Development of effervescent granules of corn milk supplemented with probiotic lactobacillus strain shirota. Int J Appl Pharm 2018;10:71-5.
Masaad AMA, Shayoub MEA, Maghrabi IA, Masaad NMA. In vitro-in vivo correlation study of a newly formulated effervescent ciprofloxacin tablets with reference tablets. Int J Curr Res Chem Pharm Sci 2016;3:1-12.
