SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF TELMISARTAN BY SOLID DISPERSION AND PELLETIZATION TECHNIQUES USING SOLUPLUS AS CARRIER

VISWANADH KUNAM; DEVALA RAO GARIKAPATI; VIDYADHARA SURYADEVARA; VENKATA BASAVESWARA RAO MANDAVA; RAMESH BABU JANGA; SIVA PRASAD SUNKARA

doi:10.22159/ijap.2020v12i1.35620

Authors

VISWANADH KUNAM Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019, Andhra Pradesh, India
DEVALA RAO GARIKAPATI Department of Pharmaceutical Analysis, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada 520010
VIDYADHARA SURYADEVARA Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019, Andhra Pradesh, India
VENKATA BASAVESWARA RAO MANDAVA Department of Pharmacy and Chemistry, Chairman, BOS, Chemistry and Pharmacy, Krishna University, Machilipatnam 521001, Krishna Dist., Andhra Pradesh, India
RAMESH BABU JANGA Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019, Andhra Pradesh, India
SIVA PRASAD SUNKARA Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijap.2020v12i1.35620

Keywords:

Telmisartan, Soluplus, Crospovidone, HPMC E5, Solid dispersions, Pellets

Abstract

Objective: In the present investigation, an attempt was made to improve the surface characters and solubility of the drug by solid dispersion and coating it on the nonpareil sugar beads as pellets.

Methods: Telmisartan solid dispersions were prepared by kneading method using soluplus. Crospovidone was added as disintegrant in pellets. Telmisartan pellets were prepared by dissolving soluplus and crospovidone in ethanol in different ratios and coated on nonpareil sugar beads as a drug layer by pan coating technique. Various physicochemical parameters like particle size, friability, angle of repose and drug content were evaluated for the prepared solid dispersions and pellet formulations. In vitro dissolution studies were carried out in pH 7.5 phosphate buffer using USP apparatus II. Fourier Transform Infrared Spectrometry, Differential Scanning Calorimetry and Scanning Electron Microscopic analysis were performed for solid dispersions, pellet formulations and its polymers to determine the interactions and surface characteristics.

Results: The physicochemical parameters were within the specified I. P limits. It was observed that the solid dispersion formulation TS₅containing 1:5 ratio of telmisartan to soluplus showed better dissolution rate to the extent of 1.143 folds and 2.033 folds when compared to a marketed formulation and the pure drug, respectively. Similarly, pellet formulation TP₃containing 1:3 ratio of telmisartan to soluplus showed an improved dissolution rate to the extent of 1.221 folds and 2.170 folds when compared to the marketed formulation and the pure drug, respectively. FTIR and DSC analysis revealed that there was no major interaction between the drug and the excipients.

Conclusion: From the present study, it was observed that the solubility of telmisartan was enhanced by soluplus in pellet formulations when compared to solid dispersions.

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