PREPARATION OF ORAL CURCUMIN DELIVERY FROM 3D-NANO-CELLULOSE NETWORKS MATERIAL PRODUCED BY ACETOBACTER XYLINUM USING OPTIMIZATION TECHNIQUE

THANH XUAN NGUYEN; HUONG LAN THI PHAM; THUONG THI NGO; PHONG XUAN ONG

doi:10.22159/ijap.2020v12i2.36627

Authors

THANH XUAN NGUYEN Institute of Scientific Research and Applications, Hanoi Pedagogical University 2; Xuan Hoa, Phuc Yen, Vinh Phuc 280000, Vietnam
HUONG LAN THI PHAM Institute of Scientific Research and Applications, Hanoi Pedagogical University 2; Xuan Hoa, Phuc Yen, Vinh Phuc 280000, Vietnam
THUONG THI NGO Institute of Scientific Research and Applications, Hanoi Pedagogical University 2; Xuan Hoa, Phuc Yen, Vinh Phuc 280000, Vietnam
PHONG XUAN ONG Institute of Scientific Research and Applications, Hanoi Pedagogical University 2; Xuan Hoa, Phuc Yen, Vinh Phuc 280000, Vietnam

DOI:

https://doi.org/10.22159/ijap.2020v12i2.36627

Keywords:

Acetobacter xylinum, Characterization, Curcumin, Loading, Optimization, 3D-nano-cellulose networks material (3DCM)

Abstract

Objective: To prepare oral curcumin delivery and optimize curcumin loading of 3D-nano-cellulose networks material (3DCM) by looking into the impact of process variables on the response utilizing response surface methodology (RSM) and Box-Behnken design.

Methods: Optimization of curcumin loading of 3DCM was conducted using RSM and Box-Behnken model. Impact of four independent variables, including, the concentration of curcumin (X₁), temperature (X₂), shaking speed (X₃), and time of loading (X₄), was studied on one dependent response, that is, an amount of loaded curcumin (Y). Characterization of optimized 3DCM including curcumin was examined by Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) analysis .

Results: R² value for Y was approximately 0.94. X₁ possessed the biggest positive impact compared to X₂, X₃ and X₄. Optimized conditions for curcumin loading of 3DCM were X₁ at 3 mg/ml, X₂ at 40 °C, X₃ at 120 rpm and X₄ at 120 min. SEM photograph of 3DCM surfaces were found including fibers creating a 3D network structure. FTIR spectra studies depicted that there was no interaction between curcumin and 3DCM.

Conclusion: The data obtained in this study thus suggest that curcumin loaded 3DCM was successfully fabricated to give a potential oral delivery system of curcumin.

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Author Biography

THANH XUAN NGUYEN, Institute of Scientific Research and Applications, Hanoi Pedagogical University 2; Xuan Hoa, Phuc Yen, Vinh Phuc 280000, Vietnam

Thanh Xuan Nguyen is a main lecturer and a director of Institute of Scientific Research and Applications at Hanoi Pedagogical University 2 (HPU2). He received a Bachelor of Science in Biology and Chemistry in 2000 from HPU2, Vietnam. He was awarded the second prize of the Vietnamese scientific and technical creative competition in 1999 of the Vietnam Fund for Supporting Technological Creations (VIFOTEC), and the second prize of the Student Scientific Research in 1999 of the Ministry of Education and Training (MOET), Vietnam. He also received a Master of Science in Human and Animal Physiology in 2005 from the Hanoi National University of Education, Vietnam. In 2010, he won a full scholarship and became a PhD student of Biopharmaceutical Engineering at Huazhong University of Science and Technology (HUST), China. He received his PhD degree from HUST, in 2014. His research interests focus on Biopharmaceutical Engineering, application of bio-pharmaceutical engineering (new materials, bio-nanomaterials, multifunctional materials, and so on) to design and manufacture the intelligent carrier systems for drug delivery and the functionally active substances in the body.

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