DESIGN-EXPERT SOFTWARE (DOE): AN APPLICATION TOOL FOR OPTIMIZATION IN PHARMACEUTICAL PREPARATIONS FORMULATION

IYAN SOPYAN; DOLIH GOZALI; SRIWIDODO; RIZKA KHOIRUNNISA GUNTINA

doi:10.22159/ijap.2022v14i4.45144

Authors

IYAN SOPYAN Department of Pharmaceutics and Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia, 45632, Center of Phamaceutical Dosage Form Development, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia, 45632 https://orcid.org/0000-0001-7616-5176
DOLIH GOZALI Department of Pharmaceutics and Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia, 45632 https://orcid.org/0000-0001-7616-5176
SRIWIDODO Department of Pharmaceutics and Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia, 45632
RIZKA KHOIRUNNISA GUNTINA Department of Pharmaceutics and Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia, 45632

DOI:

https://doi.org/10.22159/ijap.2022v14i4.45144

Keywords:

Formulation, Optimization, Software, Design expert

Abstract

Formulation is a crucial stage in drug development since it determines the best formula. The quality of the preparation is good and fulfills the standard parameters when using the best formula. This stage is completed through laboratory experiments that take a long time to complete. To address this, software utilizing computer technology, such as software Design Expert, can be used. The goal of this investigation is to see how Design Expert is used in research formulation and optimization. The method of writing a review was carried out by searching Google Scholar and Science Direct with the keywords "Formulation" and "Design Expert," yielding 63 articles, which were then screened using inclusion criteria, notably field of research on formulation optimization accepted for publication between 2011 and April 2020, and exclusion in the form of review articles. The review's findings suggest that the platform is widely utilized and effective at reducing the number of trials, time, and costs associated with formulation development.

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