ARRHENIUS KINETICS IN THE EVALUATION OF THE BIOLOGICAL ACTIVITY OF PHARMACEUTICAL TINCTURES

TATIANA V. PLETENEVA; DARIA A. GALKINA; OLGA A. FATKULINA; DAIAANA D. OGOTOEVA; OLGA V. LEVITSKAYA; ELENA V. USPENSKAYA; ANTON V. SYROESHKIN

doi:10.22159/ijap.2023v15i4.48058

Authors

TATIANA V. PLETENEVA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0000-0001-7297-980X
DARIA A. GALKINA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0000-0002-0270-2888
OLGA A. FATKULINA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0000-0001-5168-6063
DAIAANA D. OGOTOEVA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation https://orcid.org/0000-0002-3691-3261
OLGA V. LEVITSKAYA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation
ELENA V. USPENSKAYA Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation
ANTON V. SYROESHKIN Рeoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow-117198, Russian Federation

DOI:

https://doi.org/10.22159/ijap.2023v15i4.48058

Keywords:

Tinctures, Spirotox-test, Arrhenius kinetics, Activation energy, LALLS, DLS, Electrokinetic potential

Abstract

Objective: To develop a method for identifying tinctures by assessing their biological activity at different temperatures based on Arrhenius kinetics.

Methods: The tinctures of anti-inflammatory and cardiotonic actions were chosen for the Spitotox-test. Chromatographic ethanol (HPLC grade, 99.8%, Fisher Scientific, UK) and deionized high-resistance water (18.2 MΩ cm, Milli-Q, Millipore) were used to prepare 70% water-alcohol extractant. The dispersity of the infusions and solvents was evaluated by LALLS (Malvern, UK) (micrometer range) and DLS (nanometer range) (Zetasizer Nano ZS, Malvern, UK) methods.

Results: The observed (obs) values of activation energy ( °^bsE_a) of ligand-receptor interactions of infusoria Spirostomum ambiguum and components of tinctures with regard to the extractant: water volume ratio was ranked in descending order of toxicity: motherwort (1:10; 87±13 kJ/mol)>calendula (1:7; 103±18 kJ/mol)>eucalyptus (1:7; 159±5 kJ/mol)>valerian (1:5; 135±6 kJ/mol)>hawthorn (1:4; 113±20 kJ/mol). The found values of activation energy were included in the previously created library for the construction of the correlation diagram « °^bsE_a-LD₅₀», which allowed to assess the toxicity of tinctures in comparison with other pharmaceutical substances.

Conclusion: The method for assessing the biological activity of tinctures was developed by Arrhenius kinetics. The values of activation energy °^bsE_a of ligand-receptor interactions can be used for the identification of tinctures.

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References

World Health Organization (WHO). WHO Traditional Medicine Strategy 2014-2023. Geneva: World Health Organization. 2013. p. 1-76. Available from: https://apps.who.int/iris/handle/10665/92455. [Last accessed on 06 May 2023]

Nath R, Kityania S, Nath D, Talkudar AD, Sarma G. An extensive review on medicinal plants in the special context of economic importance. Asian J Pharm Clin Res. 2023;16(2):6-11. doi: 10.22159/ajpcr.2023.v16i2.46073.

Rahul G, Nandhakumar E. A systematic review of five herbal ingredients for the management of diabetes mellitus. Asian J Pharm Clin Res. 2022;15(12):18-23. doi: 10.22159/ajpcr.2022.v15i12.45427.

Ahmad F, Kamaraj B, Mohamed JMM, Ebrahim D, Al Humoud SY, El-sagheer AM. Ethnopharmacological and phytochemical study of major species from labiatae family in saudi arabia: a systematic review. Int J App Pharm 2022;1:44-57. doi: 10.22159/ijap.2022.v14ti.40.

European Pharmacopoeia 11.2. Strasburg: EDQM Council of Europe; 2023. Available from: https://online.uspnf.com/uspnf. [Last accessed on 06 May 2023]

United States Pharmacopeia. Rockville (MD): United States Pharmacopeial Convention, USA. Vol. 2022;2(3). Available from: https://pheur.edqm.eu/subhome/11 [cited May 6 2023].

Shinjyo N, Waddell G, Green J. Valerian root in treating sleep problems and associated disorders-a systematic review and meta-analysis. J Evid Based Integr Med. 2020;25:2515690X20967323. doi: 10.1177/2515690X20967323, PMID 33086877, PMCID 7585905.

European Pharmacopoeia 11.2. Strasburg: EDQM Council of Europe. Valerian Tincture. 2023. p. 1771-2. Available from: https://online.uspnf.com/uspnf. [Last accessed on 06 May 2023]

Lunz K, Stappen I. Back to the roots-an overview of the chemical composition and bioactivity of selected root-essential oils. Molecules. 2021;26(11). doi: 10.3390/molecules26113155. PMID 34070487.

Zhang RH, Liu ZK, Yang DS, Zhang XJ, Sun HD, Xiao WL. Phytochemistry and pharmacology of the genus Leonurus: the herb to benefit the mothers and more. Phytochemistry. 2018;147:167-83. doi: 10.1016/j.phytochem.2017.12.016. PMID 29335190.

Wardana MS, Jufri M, Munim A. Physicochemical properties and nutrition of moringa oleifera lam. leaf extract: a preliminary study on preparation phytosomes as herbal supplement for children. Int J App Pharm. 2022;14(1):281-7. doi: 10.22159/ijap.2022v14i1.43477.

Maurya H, Kumar T. Formulation, standardization, and evaluation of polyherbal dispersible tablet. Int J App Pharm. 2019;11(1):158-67. doi: 10.22159/ijap.2019v11i1.30113.

Goncharuk VV, Syroeshkin AV, Zlatskiy IA, Uspenskaya EV, Orekhova AV, Levitskaya OV. Quasichemical description of the cell death kinetics of cellular biosensor Spirostomum ambigua for testing the biological activity of aqueous solutions. J Water Chem Technol. 2017;39(2):97-102. doi: 10.3103/S1063455X17020072.

Way2Drug. Available from: http://www.way2drug.com/passonline/. Last 06 May 2023]

Duc Nguyen HD. Neurotherapeutic effects of quercetin and its metabolite compounds on cognitive impairment and Parkinson’s disease: an in silico study. Eur J Drug Metab Pharmacokinet. 2023;48(2):151-69. doi: 10.1007/s13318-023-00816-w, PMID 36848007.

Merlani M, Nadaraia N, Amiranashvili L, Petrou A, Geronikaki A, Ciric A. Antimicrobial activity of some steroidal hydrazones. Molecules. 2023;28(3):36770834. doi: 10.3390/molecules28031167, PMID 36770834, PMCID PMC9920613.

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Addendum to Assessment report on Eucalyptus globulus Labill. folium; 2022. Available from: https://www.ema.europa.eu/en/medicines/herbal/eucalypti-folium. [Last accessed on 06 May 2023]

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Assessment report on Calendula officinalis L., flos; 2018. Available from: https://www.ema.europa.eu/en/medicines/herbal/calenduleae-flos. [Last accessed on 06 May 2023]

Patan A. Valeriana jatamansi: an ethnobotanical review. Asian J Pharm Clin Res. 2018;11(16):38-40. doi: 10.22159/ajpcr.2018.v11s4.31706.

Das G, Shin HS, Tundis R, Gonçalves S, Tantengco OAG, Campos MG. Plant species of sub-family valerianaceae-a review on its effect on the central nervous system. Plants (Basel). 2021;10(5):846. doi: 10.3390/plants10050846, PMID 33922184.

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Assessment report on Leonurus cardiaca L., herba; 2010. Available from: https://www.ema.europa.eu/en/medicines/herbal/leonuri-cardiacae-herba. [Last accessed on 06 May 2023]

Angeloni S, Spinozzi E, Maggi F, Sagratini G, Caprioli G, Borsetta G. Phytochemical profile and biological activities of crude and purified Leonurus cardiaca extracts. Plants (Basel). 2021;10(2):195. doi: 10.3390/plants10020195, PMID 33494336.

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Addendum to Assessment report on Leonurus cardiaca L. herba; 2019. Available from: https://www.ema.europa.eu/en/medicines/herbal/leonuri-cardiacae-herba [Last accessed on 06 May 2023]

Nazhand A, Lucarini M, Durazzo A, Zaccardelli M, Cristarella S, Souto SB. Hawthorn (Crataegus spp.): an updated overview on its beneficial properties. Forests. 2020;11(5):564. doi: 10.3390/f11050564.

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Assessment report on Crataegus spp.; 2016. Available from: https://www.ema.europa.eu/en/medicines/herbal/crataegi-folium-cum-flore. [Last accessed on 06 May 6]

Syroeshkin AV, Pleteneva TV, Uspenskaya EV, Zlatskiy IA, Antipova NA, Grebennikova TV. D/H control of chemical kinetics in water solutions under low deuterium concentrations. Chem Eng J. 2019;377:119827. doi: 10.1016/j.cej.2018.08.213.

Syroeshkin AV, Ogotoeva DD, Galkina DA, Uspenskaya EV, Pleteneva TV. Polarimetry and dynamic light scattering in quality control of cardiotonic and hypotensive tinctures. Int J App Pharm. 2022;14(6):114-9. doi: 10.22159/ijap.2022v14i6.45907.

Clogston JD, Patri AK. Zeta potential measurement. Methods Mol Biol. 2011;697:63-70. doi: 10.1007/978-1-60327-198-1_6, PMID 21116954.

Ferreyra Maillard APV, Espeche JC, Maturana P, Cutro AC, Hollmann A. Zeta potential beyond materials science: applications to bacterial systems and to the development of novel antimicrobials. Biochim Biophys Acta Biomembr. 2021;1863(6):183597. doi: 10.1016/j.bbamem.2021.183597. PMID 33652005.

European Medicines Agency. Committee on Herbal Medicinal Products, European Union. Assessment report on Valeriana officinalis L., radix and Valeriana officinalis L.; 2016. Available from: https://www.ema.europa.eu/en/medicines/herbal/Valerianae-radix. [Last accessed on 06 May 2023]