FORMULATION AND DEVELOPMENT OF MUCOADHESIVE NASAL DRUG DELIVERY OF ROPINIROL HCL FOR BRAIN TARGETING

AMRUTA SONAWANE; GAYATRI JAWALE; NITIN DEVHADRAO; ASHWINI BANSODE; JYOTI LOKHANDE; DHANASHREE KHERADE; PRATIKSHA SATHE; NITIN DESHMUKH; GANESH DAMA; HARSHAL TARE

doi:10.22159/ijap.2023v15i5.48437

Authors

AMRUTA SONAWANE Department of Pharmaceutics, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0009-0002-2084-2339
GAYATRI JAWALE Department of Pharmaceutics, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0009-0007-4180-9147
NITIN DEVHADRAO Department of Pharmaceutics, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0000-0002-9643-0675
ASHWINI BANSODE Department of Pharmaceutics, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0000-0002-7212-0568
JYOTI LOKHANDE Department of Pharmaceutics, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0009-0002-9663-2186
DHANASHREE KHERADE Department of Pharmaceutical Chemistry, Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Alandi, Pune-412105, Maharashtra, India https://orcid.org/0000-0002-4167-7646
PRATIKSHA SATHE Department of Pharmacognosy, Shriram Shikshan Sanstha’s College of Pharmacy, Paniv, Malshiras, Solapur-413113, Maharashtra, India https://orcid.org/0009-0008-1090-5491
NITIN DESHMUKH Department of Science and Technology, Savitribai Phule Pune University, Pune-411007, Maharashtra, India https://orcid.org/0009-0001-1379-0465
GANESH DAMA Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Otur, Savitribai Phule Pune University, Pune-411007, Maharashtra, India https://orcid.org/0000-0002-4993-6841
HARSHAL TARE Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Otur, Savitribai Phule Pune University, Pune-411007, Maharashtra, India https://orcid.org/0000-0002-4404-5396

DOI:

https://doi.org/10.22159/ijap.2023v15i5.48437

Keywords:

Ropinirole , HCl, Nanoparticles, Box-behnken, Mucoadhesion, Encapsulation

Abstract

Objective: The purpose of this research was to create polymeric nanoparticles of ropinirole HCl for nasal administration utilising the ionic gelation process.

Methods: The preparation method was optimized using box-behnken design employing chitosan concentration, guar gum concentration and surfactant concentration as independent variables were as Encapsulation efficiency and mucoadhesion of the formulation were selected as dependent variables. Differential scanning calorimetry and infrared spectroscopy analysis of the drug and polymers revealed that the drug and excipients are physicochemically compatible. Studies on entrapment efficiency, drug content, and In vitro release were conducted on the nanoparticles.

Results: Each formulation was determined to have a drug content of between 60% and 70% and an entrapment efficiency of between 65% and 84%. In vitro drug release tests demonstrated that ropinirole HCl will release between 65 and 81 percent after 5 h.

Conclusion: The results showed that the particle size, encapsulation effectiveness, and drug content were all significantly affected by the amounts of chitosan and guar gum.

Downloads

Download data is not yet available.

References

Marieb EN. Essential of human anatomy and physiology. 7th ed. San Francisco: Benjamin-Cummings; 2003.

Kaiser GE. The innate immune system. Doc Kaiser’s microbiology home page. Community college Baltimore County; 2007.

Orahilly R, Muller F, Carpenter S, Swenson R. Chapter 52. Basic human anatomy. R Swenson. In: Dartmouth Medical School, editor. The nose and paranasal sinuses; 2008.

Mann MD. Chapter 10. The nervous system in action. In: Gustatory and Olfactory senses. University of Nebraska Medical Center; 2008.

Des Jardins TR. Chapter 1. Cardiopulmonary anatomy and physiology-Essentials of Respiratory Care. The anatomy and physiology of the respiratory system. 5th ed; 2008. p. 3-66.

Dykewicz MS. Rhinitis and sinusitis. J Allergy Clin Immunol. 2003;111(2)Suppl:S520-9. doi: 10.1067/mai.2003.82, PMID 12592298.

Pawankar R, Mori S, Ozu C, Kimura S. Overview on the pathomechanisms of allergic rhinitis. Asia Pac Allergy. 2011;1(3):157-67. doi: 10.5415/apallergy.2011.1.3.157, PMID 22053313.

Van Cauwenberge PB. Nasal sensitization. Allergy. 1997;52(33)Suppl:7-9. doi: 10.1111/j.1398-9995.1997.tb04797.x, PMID 9188940.

Nguyen TP, Caberlotto L, Morine MJ, Priami C. Network analysis of neurodegenerative disease highlights a role of toll-like receptor signaling. BioMed Res Int. 2014;2014:686505. doi: 10.1155/2014/686505, PMID 24551850.

Pardeshi CV, Belgamwar VS. Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting. Expert Opin Drug Deliv. 2013;10(7):957-72. doi: 10.1517/17425247.2013.790887, PMID 23586809.

Mittal D, Ali A, Md S, Baboota S, Sahni JK, Ali J. Insights into direct nose to brain delivery: current status and future perspective. J Drug Deliv. 2014;21(2):75-86. doi: 10.3109/10717544.2013.838713.

Kumar A, Pandey AN, Jain SK. Nasal-nanotechnology: revolution for efficient therapeutics delivery. Drug Deliv. 2016;23(3):681-93. doi: 10.3109/10717544.2014.920431. PMID 24901207.

Nasreen A, Priyanka K. An overview on brain targeting drug delivery system. Int J Adv Pharm. 2015;5(2):112-8.

Prajapati N, Srivastava P, Bhargava S. Recent advances in nasal drug delivery using natural polymers. Curr Drug Ther. 2012;7(3):170-8. doi: 10.2174/157488512803988076.

Pavuluri P, Velmula M, Rao UM. Nanotechnology-mediated nose to brain drug delivery for Parkinson’s disease: a mini review. World J Pharm Pharm Sci. 2015;4(7):522-37.

Ugwoke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol. 2001;53(1):3-21. doi: 10.1211/0022357011775145, PMID 11206189.

Olivier JC. Drug transport to brain with targeted nanoparticles. Neurorx. 2005;2(1):108-19. doi: 10.1602/neurorx.2.1.108, PMID 15717062.

Velavan P, Karuppusamy C, Venkatesan P. Nanoparticles as drug delivery systems. J Pharm Sci Res. 2015;7(12):1118-22.

Dhuria SV, Hanson LR, Frey WH. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci. 2010;99(4):1654-73. doi: 10.1002/jps.21924, PMID 19877171.

Mistry A, Stolnik S, Illum L. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm. 2009;379(1):146-57. doi: 10.1016/j.ijpharm.2009.06.019, PMID 19555750.

Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci. 2000;11(1):1-18. doi: 10.1016/s0928-0987(00)00087-7, PMID 10913748.

Dhakar RC, Maurya SD, Tilak VK, Gupta AK. A review on factors affecting the design of nasal drug delivery system. Int J Drug Deliv. 2011;3:194-208.

Deka T, Das MK, Das S, Das P, Singha LR. Box-behnken design approach to develop nano-vesicular herbal gel for the management of skin cancer in experimental animal model. Int J App Pharm. 2022 Nov 7;14(6):148-66. doi: 10.22159/ijap.2022v14i6.45867.

Arpna I, Ahmed Masheer K. Box-behnken design for optimization of formulation variables for controlled release gastroretentive tablet of verapamil hydrochloride. Int J App Pharm. 2023 Jan 7;15(1):256-63. doi: 10.22159/ijap.2023v15i1.46489.

Gopi G, Kannan K. Formulation development and optimization of nateglinide-loaded ethyl cellulose nanoparticles by box-behnken design. Int J Pharm Pharm Sci. 2015 Sep 1;7(9):310-5.

Singh S, Singla YP, Arora S. Statistical, diagnostic and response surface analysis of nefopam hydrochloride nanospheres using 35 box-behnken design. Int J Pharm Pharm Sci. 2015 Oct 1;7(11):89-101.

Purba NB, Rohman AB, Martono SU. The optimization of HPLC for quantitative analysis of acid orange 7 and sudan II incosmetic products using box behnken design. Int J Appl Pharm. 2019;11(2):130-7.

Keerthana V, Dhanalakshmi S, Harikrishnan N. A perspective review on applications of nanoparticle mediated drug delivery to the cns. Int J Curr Pharm Sci. 2020 Jan 15;12(1):1-4. doi: 10.22159/ijcpr.2020v12i1.36819.

Dubey ADN, Ramteke S, Jain D. Preparation and characterization of gliadin nanoparticles for brain drug delivery. Asian J Pharm Clin Res. 2018 Jul 7;11(7):345-7. doi: 10.22159/ajpcr.2018.v11i7.25478.

https://journals.innovareacademics.in/index.php/ajpcr/article/view/25478. [Last accessed on 24 Jul 2023]