ULTRA-FAST SYNTHESIS OF CURCUMIN-LOADED SILVER NANOPARTICLES: IMPROVED PHYSICOCHEMICAL PROPERTIES FOR DRUG DELIVERY

CHONG XUE LI; GAMAL OSMAN ELHASSAN; SIHAM A. ABDOUN; RIYAZ AHMED KHAN; MANOJ GOYAL; MONIKA BANSAL; JAMAL MOIDEEN MUTHU MOHAMED

doi:10.22159/ijap.2025v17i1.52647

Authors

CHONG XUE LI Faculty of Pharmacy and BioMedical Sciences, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia
GAMAL OSMAN ELHASSAN Department of Pharmaceutics, College of Pharmacy, Qassim University, Buriadah, K. S. A. https://orcid.org/0000-0001-9116-2520
SIHAM A. ABDOUN Department of Pharmaceutics, College of Pharmacy, Qassim University, Buriadah, K. S. A. https://orcid.org/0000-0001-8970-3236
RIYAZ AHMED KHAN Department of Pharmaceutics, College of Pharmacy, Qassim University, Buriadah, K. S. A.
MANOJ GOYAL Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Dammam, Saudi Arabia
MONIKA BANSAL Department of Neuroscience Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Dammam, Saudi Arabia
JAMAL MOIDEEN MUTHU MOHAMED Faculty of Pharmacy and BioMedical Sciences, MAHSA University, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia https://orcid.org/0000-0001-6362-8629

DOI:

https://doi.org/10.22159/ijap.2025v17i1.52647

Keywords:

Drug delivery, green synthesis, Drug formulation, AgNPs, Curcumin, In vitro study, Garlic extract

Abstract

Objective: This study focused on the green synthesis of silver nanoparticles (AgNPs) using fresh garlic extract (Allium sativum-AS) as a reducing agent for the efficient delivery of curcumin (CuR), a natural anti-cancer agent used in breast cancer therapy.

Methods: The study began with the preparation of fresh AS, which was then mixed with silver nitrate (AgNO₃) solution and CuR solution under sunlight for the green synthesis of stable CuR-loaded nanoparticles (C-AgNPs). This method not only offered an eco-friendly approach to the synthesis of C-AgNPs but also highlighted the potential physicochemical characterization of AS and CuR in this context. Moreover, this study assesses the characteristics of the resulting C-AgNPs and conducts a comparative analysis with different formulations to evaluate their efficacy.

Results: The prepared C-AgNPs, characterized by Fourier-Transform Infrared Spectroscopy (FTIR), indicated that CuR, silver nitrate (AgNO₃), and AS extract were successfully incorporated, confirming the successful synthesis. The optimized preparation, referred to as AgNP1, demonstrated an entrapment efficacy of 74.24±5.87%, a drug loading of 95.99±7.81%, and a drug content of 96.11±7.82%. Additionally, the cumulative percentage of drug release was found to be 57.12±2.76% at 180 min. The drug was successfully loaded into the C-AgNPs, exhibiting physicochemical compatibility without any adverse chemical interactions with the additives used.

Conclusion: In conclusion, this study demonstrated that nanoparticle-based drug delivery systems offer a significant advancement over conventional therapies by providing controlled and efficient drug delivery, thereby improving therapeutic outcomes.

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