EVALUATION OF THE DETERMINATION AND IMPLEMENTATION OF BEYOND-USE DATE (BUD) TO NON-STERILE EXTEMPORANEOUS COMPOUNDED MEDICINES BY PHARMACISTS IN SUKOHARJO INDONESIA

HIDAYAH KARUNIAWATI; MARSILIA ROSA SINENSIS HI

doi:10.22159/ijap.2024.v16s6.SE2016

Authors

HIDAYAH KARUNIAWATI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia
MARSILIA ROSA SINENSIS HI Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2024.v16s6.SE2016

Keywords:

Extemporaneous compounding, Beyond use date, Pharmacist, Expired date

Abstract

Objective: This research aims to evaluate pharmacists' determination and implementation of Beyond-Use Date (BUD) for extemporaneously compounded medicines from non-sterile drugs and the factors that influence it.

Methods: This research is a non-experimental cross-sectional study that used a validated questionnaire with the cluster sampling method applied to select pharmacists. The data were analyzed statistically using the Mann-Whitney, Kruskal Wallis tests and Spearman Correlation.

Results: Of the 181 pharmacists who participated, 161 (89.0%) were aged 26–45 years, 160 (88.4%) were women, 118 (65.2%) were married, and 173 (95.6%) had a bachelor's degree with a profession. Around 75%–77% of respondents calculate BUD on the extemporaneous compounded and mark BUD on the drug label or medicine packaging. Around 80% of pharmacists inform patients about BUD, but only 65% ensure patients understand it. Age, marital status, education level, length of work experience, and income significantly influence the determination and implementation of BUD (P<0.05). Knowledge has a significant relationship with pharmacists' attitudes (r = 0.836) and behavior (r = 0.646) towards BUD

Conclusion: The role of pharmacists in determining and implementing BUD in extemporaneously compounded medicines needs to be improved to ensure maximum drug quality, safety, and optimal therapy.

Downloads

Download data is not yet available.

References

USP. USP compounding standards and beyond-use dates updates to BUDs in compounding standards. In: USP; 2022. Available from: www.usp.org/compounding [Last accessed on 24 Apr 2024].

Pertiwi GS. Tingkat pengetahuan mahasiswa program studi farmasi fakultas kedokteran universitas mataram tentang beyond use date obat. JKU. 2021;10(2):435-40. doi: 10.29303/jku.v10i2.550.

Nilansari AF, Wardani S, Widyawarman D. Edukasi beyond use date obat rumah tangga DI desa demangan kecamatan gondokusuman. Reswara J Pengabdi KPD Masy. 2022;3(2):771-7. doi: 10.46576/rjpkm.v3i2.1995.

Kusuma IY, Octaviani P, Muttaqin CD, Lestari AD, Rudiyanti F, Sa’diah HF, Sa’diah H. Upaya peningkatan pemahaman masyarakat terhadap beyond use date didesa kecepit kecamatan punggelan kabupaten banjarnegara pelita abdi masyarakat. J Pelita Abdi Masy. 2020;1(1):22-9.

Priyoherianto A, Puspadina V, Tingkat Pengetahuan CP, Terhadap P. Beyond use. J Farm Indones. 2023;4(1):6-11.

Cokro F, Arrang ST, Chiara MA, Hendra OS. Prevalence of pharmacist knowledge on beyond use date (BUD) of various non-sterile compounding drugs in Indonesia. Pharm Pract (Granada). 2022 Jan 1;20(1):2630. doi: 10.18549/PharmPract.2022.1.2630, PMID 35497902.

Kementrian kesehatan republik Indonesia. Kemenkes RI Peraturan Menteri Kesehtan Republik Indonesia tentang Standar Pelayanan Kefarmasian di Klinik. Kementrian Kesehat Republik Indones. 2021;101.

BPOM R. Waspada obat kadaluwarsa. Badan Pengawas Obat Makanan; 2019.

Christina F. Beyond use date produk nonsteril. Media Inf Peresepan Rasional Bagi Tenaga Kesehat Indones. 2012;10(3):18-24.

Dodi Sukma RA, Hardianto R, Heleni Filtri. Analisa tingkat kepuasan mahasiswa terhadap perkuliahan daring pada era pandemi COVID-19. Publikasi Artikel ZONAsi: Jurnal Sistem Informasi. 2021;3(2):130-42. doi: 10.31849/zn.v3i2.8353.

Dahlan S. Statistik untuk kedokteran dan kesehatan. Jakarta: Epidemiologi; 2015.

Tobing L, Sinaga YV, Tingkat N. Pengetahuan masyarakat mengenai epilepsi di lingkungan X kelurahan tegal sar I mandala II medan. Anat Med J. 2021;4(1):43.

Lestari I, Hanum F, Peluang Kerja DPP, DI CVP. Indah Bantul. J Pendidik Sosiol. 2020;9(1):2-17.

LI Z, Liu J, LI H, Huang Y, XI X. Primary healthcare pharmacists perceived organizational support and turnover intention: do gender differences exist? X. Psychol Res Behav Manag. 2023 Apr 14;16:1181-93. doi: 10.2147/PRBM.S406942, PMID 37082527.

Algazlan N, Al Jedai A, Alamri A, Alshehri AM, Aldaiji L, Almogbel Y. Association between intention to leave work and quality of work life of Saudi pharmacists. Saudi Pharm J. 2022;30(2):103-7. doi: 10.1016/j.jsps.2021.12.022, PMID 35528856.

Gubbins PO, Ragland D, Castleberry AN, Payakachat N. Family commitment and work characteristics among pharmacists. Pharmacy (Basel). 2015;3(4):386-98. doi: 10.3390/pharmacy3040386, PMID 28975924.

Sofyan DM, Hubungan Tingkat O, Tingkat PT. Pengetahuan masyarakat di dusun sumberan sedayu bantul tentang pencegahan COVID-19 bulan january 2021. Maj Farm. 2022;18(2):220-6. doi: 10.22146/farmaseutik.v18i2.70171.

Khairunnisa Z Khairunnisa Z, Sofia R, Magfirah S. Hubungan karakteristik dan tingkat pengetahuan dengan perilaku pencegahan COVID-19 pada masyarakat desa paya bujok blang pase kota langsa. Averrous J Kedokt Kesehat Malikussaleh. 2021;7(1):53. doi: 10.29103/averrous.v7i1.4395.

SA Adah L, Martadani L, Taqiyuddin A. Analisis perbedaan kinerja karyawan PADA PT surya indah food multirasa jombang. J Inov Penelit. 2021;2(2):515-22.

Hadning I, Rahajeng B, Utami P, Khairiati SM, Wardhani N, Ramadhani NL. Evaluasi pelaksanaan peraturan penetapan standar jasa profesi apoteker di daerah istimewa yogyakarta. Jurnal Manajemen Dan Pelayanan Farmasi. 2022;12(2):65. doi: 10.22146/jmpf.61125.

Gusti Ebtavanny T, Lu’lu’il Firdauzia D, Rachma Pramestuti H, Lawuningtyas Hariadini A, Kurnia Illahi R. Hubungan antara tingkat pengetahuan dan ketepatan apoteker dalam mengelola obat sisa, obat rusak, dan obat kedaluwarsa di apotek malang raya. PJI. 2021;9(1):49-55. doi: 10.20473/jfiki.v8i32021.250-258.

Kurniawan AH, Hasbi F, Arafah MR. Pengkajian pengetahuan sikap dan determinasi pengelolaan beyond use date obat di rumah tangga wilayah kecamatan menteng jakarta pusat. Maj Farm Farmakol. 2023;15-21.

Anggianingrum R, Ramadhan RF, Hadi S, Setiawan D. Sosialisasi batas penggunaan obat atau beyond use date (BUD) di apotek kimia farma 188. J Pengabdi Masy Panacea. 2023;1(4):110-5. doi: 10.20527/jpmp.v1i4.10362.

Netta SN, lilla H PA. Relationship between knowledge and behaviour of self-medication in cough towards one community in east java. Pharmacon. J Farmasi Indones. 2024 Apr 8;21(1):37-48.

Harlianti MS, Andayani TM, Puspandari DA. Willingness to pay pelayanan konseling apoteker di apotek di kecamatan polokarto tahun 2016. Pharmacon. 2019 Mar 14;15(1):37-41. doi: 10.23917/pharmacon.v15i1.7247.