LIPOPHILICITY PROFILING ON THE BASIC OF OECD GUIDELINE OF HARIDRA HYDROALCOHOLIC EXTRACT ON THE BASIS OF ITS MARKER COMPOUND CURCUMIN
Abstract
Objective: The objective of this study was to calculate the lipophilicity (LOG P) of Haridra extracts on the basis of their main chemical compound curcumin.
Methods: As per the OECD guidelines for the testing of chemical adopted by the council on July 27, 1995, partition, and partition coefficient (n-octanol/ water): Shake flask method, this experiment is performed in this first extracts are prepared by raw herbal drugs (Haridra, coarse powder). Snyder classified solvents based on their interactions with three solutes determined by their gas–liquid partition coefficients corrected for differences in solvent size, polarizability, and dispersion interactions.
Results: Haridra shows hydrophilicity and its marker compound shows LOG P.
Conclusion: Haridra is highly useful drugs its pharmacological activity is anti-inflammation, useful in the skin. However, where curcumin is more potent due to its lipophilic property. It is highly useful in various alignments.
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