FORMULATION AND EVALUATION OF VITAMIN C MEDICATED CHEWING GUM
DOI:
https://doi.org/10.22159/ijas.2025v13.53243Keywords:
Medicated Chewing gum, Biodegradable, Prolamin Gum base, Vitamin CAbstract
Objectives: The objective of the present research work was to formulate and evaluate vitamin C chewing gum.
Methods: Medicated chewing gum is formulated using a natural gum base (Prolamin) extracted from wheat. The gum base is extracted by mixing Triticum aestivum flour with 70% ethanol, stirring for 2 h, filtering, and then evaporating the filtrate. The concentrated solution is further treated to form a gum base. The formulation of the chewing gum, the gum base, and calcium carbonate are mixed in a mortar, while polyvinyl acetate, ethanol, glycerin, and other excipients are combined in another. The two mixtures are combined and thoroughly mixed to form the final chewing gum. Six formulations were prepared by varying the gum base and soya lecithin quantities. The chewing gum was evaluated for several parameters, including swelling index, water retention capacity, loss on drying, solubility, content uniformity, weight variation, drug release, and stability.
Results: The results of different evaluation parameters of prepared vitamin C chewing gum were within the standard range. Among all the formulations from F2 to F5 was good enough to meet the general characteristics of ideal chewing gum as all the evaluation parameters meet the standard values of chewing gum.
Conclusion: The natural gum base obtained from wheat (prolamin) was used, and vitamin C was used as a drug. The formulation was optimized by altering soya lecithin and the gum base. All the evaluation parameters were determined, and F2 and F5 were the best formulations obtained.
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Copyright (c) 2025 VIJAYANAND PUJARI, RESHMA SAWANT, DIVYA PHATAN, LAKSHMI KURBET, SHIVAKUMAR PASAPPAGOL, RANJITA KALLOLI
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