A COMPREHENSIVE REVIEW ON HYDROGELS

Authors

  • Santhi Priya Nagam Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, A. P.
  • A. Naga Jyothi Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, A. P.
  • J. Poojitha Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, A. P.
  • Santhosh Aruna Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, A. P.
  • Rama Rao Nadendla Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Guntur, A. P.

Keywords:

Hydrogels, Types of hydrogels, Preparation methods, Applications

Abstract

Polymers play a vital role in pharmaceutical development. Efforts have been continuously made to search a polymer that act in a controlled& desired way. Hydrogel development has solved many such issues. Hydrogels are hydrophilic, three-dimensional networks. Which are able to imbibe large amounts of water or biological fluids & thus resembles to a large extent, a biological tissue. They are insoluble due to the presence of physical or chemical crosslinks such as entanglements& crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as PH, ionic strength, temperature. The main aim of this article is to give a concise review on introduction, preparation methods, types, & various applications of hydrogels in the pharmaceutical field.

Downloads

Download data is not yet available.

References

Rakesh Yeshaswi, Prathima Srinivas, Sadanandam M. Development and characterization of microemulsion formulations for transdermal delivery of aceclofenac: a research. Int J Drug Formulation Res 2010;1:359-86.

Piyush Gupta, Kavita Vermani, Sanjay Garg. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discovery Today 2002;7:124-8.

Rowley J, Madlambayan G, Faulkner J, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1999;20:45-53.

Jen AC, Wake MC, Mikos AG. Hydrogels for cell immobilization. Biotechnol Bioeng 1996;50:357-64.

Peppas NA, Huang Y, Torres M-Lugo, Ward JH, ZhangJ. Physicochemical, foundations and structural design of hydrogels in medicine and biology. Annu Rev Biomed Eng 2000;2:9–29.

Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations Eur J Pharm Biopharm 2000;50:27–46.

Mc-Neill NE, Graham NB. Properties controlling the diffusion and release of water soluble solutes frompoly (ethyloxide) hydrogels1, Polymer composition. J Biomater Sci Poly 1993;4:305-22.

George A. Paleos, Pittsburgh plastics manufacturing. Butler PAm 1993;4:305-22.

Flory PJ. Principles of polymer chemistry, Cornell Univ. Press: Ithaca, NY; 1953. p. 672.

Zohuriaan-Mehr MJ. Super-absorbents. Tehran: Iran Polymer Society; 2006. p. 2–4.

Anisha Singh, Pramod Kumar Sharma, Vipin Kumar Garg, Garima Garg. Hydrogels: a review. Int J Pharm Sci Rev Res 2010;4:97-105.

Syed KH Gulrez, Saphwan Al-Assaf, Glyn O Phillips. Hydrogels: methods of preparation, characterisation and applications. Prog Mol Environ Bioeng: Anal Model Technol Appl 2011;5:655-60.

Zhou Y, Chu JS, Wu XY. Theoretical analysis of drug release into a finite medium from sphere ensembles with various size and concentration distributions. Eur J Pharm Sci 2004;22:251–9.

Katchalsky, I Michaeli. Polyelectrolyte gels in salt solution. J Polym Sci 1955;15:69-86.

L Brannon-Peppas, NA Peppas. Equilibrium swelling behaviour of pH-sensitive hydrogels. Chem Eng Sci 1991;46:715-22.

Katchalsky. Rapid swelling and deswelling of reversible gels of polymeric acids by ionization. Experimentia 1949;5:319-20.

Katchalsky S Lifson, H Eisenberg. Equation of swelling for poly electrolyte gels. J Polym Sci 1951;7:571-4.

T Tanaka. Phase transition in gels and a single polymer. Polymer 1979;20:1404-12.

L Brannon-Peppas, NA Peppas. The equilibrium swelling behaviour of porous and non-porous hydrogels, in: L. Brannon-Peppas, RS Harland. Eds. Absorbent Polymer Technology, Elsevier, Amsterdam; 1990. p. 67-75.

W Oppermann. Swelling behaviour and elastic properties of ionic hydrogels, in: RS Harland, RK Prud' home. Eds. Polyelectrolyte Gels: Properties, Preparation, and Applications, ACS Symposium Series, No. 480, American Chemical Society, Washington, DC; 1992. p. 159-70.

Kikuchi, T Okano. Temperature-responsive polymers as on off switches for intelligent bio-interfaces. In: T Okano. Ed. Biorelated Polymers and Gels, Academic Press: Boston, MA; 1998. p. 1-28.

Lee KY, Mooney DJ. Hydrogels for tissue engineering. Chem Rev 2001;101:1869-80.

Van der, Linden HJ, Herber S, Olthuis W, Bergveld P. Patterned dual pH responsive core shell hydrogels with controllable swelling kinetics and volume. Analyst 2003;128:325-31.

Azad AK, Sermsintham N, Chandrkrachang S, StevensWF. Chitosan membrane as a wound healing dressing: characterization and clinical applications. J Biomed Mater Res Part B 2004;69B:216-22.

Passé ERG, Blaine G. Preliminary cell culture studies on hydrogels assembled through aggregation of leucine zipper domains. Lancet 1948;255:651-1.

Merrill EW. Poly (ethyleneoxide) starmolecules synthesis, characterization, and applications in medicine and biology. Biomater Sci Polym Edn 1993;5:1–11.

Published

07-01-2016

How to Cite

Nagam, S. P., A. N. Jyothi, J. Poojitha, S. Aruna, and R. R. Nadendla. “A COMPREHENSIVE REVIEW ON HYDROGELS”. International Journal of Current Pharmaceutical Research, vol. 8, no. 1, Jan. 2016, pp. 19-23, https://mail.innovareacademics.in/journals/index.php/ijcpr/article/view/10608.

Issue

Section

Review Article(s)