EFFECT OF RANITIDINE ON HYPOGLYCAEMIC ACTIVITY OF GLIPIZIDE IN RABBITS
DOI:
https://doi.org/10.22159/ijcpr.2024v16i5.5069Keywords:
Ranitidine, Glipizide, Hypoglycaemic, Blood sugarAbstract
Objective: To study the effect of Ranitidine (H2 receptor antagonist) in combination with Glipizide on the blood sugar level in rabbits.
Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1, while was co-administrated with Ranitidine to each rabbit as a combinational drug therapy on day 7. Ranitidine was administrated to each rabbit from day 2 to day 6 as a single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h.
Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.9, 78.4, 67.2, 60.2 and 67.5 mg% and on day 7 were 90.3, 77.09, 63.3, 55.7 and 64 mg% respectively. When mean blood sugar level on day 1 and day 7 were considered, there was a significant reduction in blood sugar level at 2, 4 and 6 h but there was no significant fall in blood sugar level at 0 and 1 hour after co-administration of Glipizide and Ranitidine.
Conclusion: Ranitidine, when co-administered with glipizide, significantly increases the hypoglycaemic action of glipizide.
Downloads
References
Krishnaiah YS, Satyanarayana S, Visweswaram D. Influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide in rabbits. Indian J Physiol Pharmacol. 1994;38(4):316-8. PMID 7883304.
Ratna Tuladhar L, Lal Shrestha S, Bimali S, Bhusal S, Khadka P. Drug-drug interactions between hypoglycemic and non hypoglycemic medication in diabetic patients with comorbidities in a tertiary care center: a descriptive cross-sectional study. JNMA J Nepal Med Assoc. 2021 Nov 15;59(243):1125-30. doi: 10.31729/jnma.7080, PMID 35199748.
Kim NT, Cho CK, Kang P, Park HJ, Lee YJ, Bae JW. Effects of CYP2C9*3 and *13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects. Arch Pharm Res. 2022 Feb;45(2):114-21. doi: 10.1007/s12272021-01366-y, PMID 34952963.
Ogonowski J. Glipizide a short acting sulphonylurea derivative. Przegl Lek. 1996;53(9):666-7. PMID 8992534.
Melander A, Bitzen PO, Faber O, Groop L. Sulphonylurea antidiabetic drugs an update of their clinical pharmacology and rational therapeutic use. Drugs. 1989;37(1):58-72. doi: 10.2165/00003495-198937010-00004, PMID 2651086.
Ghosh M. Fundamental of experimental pharmacology. 2nd ed. 2015 Jan. p. 154-5.
Sharma NC, Sur BK, Shukla RK. A simplified technique for estimation of blood glucose. Indian J Physiol Pharmacol. 1972;16(4):349-53. PMID 4662715.
Feely J, Collins WC, Cullen M, El Debani AH, MacWalter RS, Peden NR. Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists. Br J Clin Pharmacol. 1993;35(3):321-3. doi: 10.1111/j.13652125.1993.tb05702.x, PMID 8471413.
Leucuta A, Vlase L, Farcau D, Nanulescu M. Pharmacokinetic interaction study between ranitidine and metoclopramide. Rom J Gastroenterol. 2004 Sep;13(3):211-4. PMID 15470533.
Published
How to Cite
Issue
Section
Copyright (c) 2024 RANJEETA GHOLVE, SAM JOHN, DHANESHWAR SHEP, MANISH RAMAVAT
This work is licensed under a Creative Commons Attribution 4.0 International License.
