ROLE OF PHYTOESTROGENS IN PREVENTION OF OSTEOPOROSIS

Authors

  • Stefka Pankova Department of Pharmacognosy and Pharmaceutical Сhemistry, Faculty of Pharmacy Medical University–Plovdiv, Bulgaria
  • Dobrina Tsvetkova Department of Pharmaceutical Сhemistry, Faculty of Pharmacy Medical University–Sofia, Bulgaria

Keywords:

Phytoestrogens, Osteoporosis, Bone, Prevention

Abstract

Osteoporosis is a disease characterized with the disbalance between the bone-building activity of osteoblasts and the re absorptive activity of osteoclasts. Estrogen deficiency occurring after menopause leads to enhanced risk of sudden fractures due to reduced bone mass.

Phytoestrogens are polyphenolic plant metabolites: isoflavonoids, flavonoids (flavones, flavanones, chalcones), lignans, stilbenes. Phytoestrogens possess estrogenic activity and display the higher affinity for β-estrogen receptor due to their structural similarity to 17β-Estradiol. It is reported that bone loss is suppressed by Genistein and Daidzein from soy products, Quercetin and Rutin, Resveratrol from grapes and red wine, Kaempferol and Apigenin, Hesperidin, (+)-Catechin and Epigallocatechin gallate from green tea and Oleuropein.

The most effective isoflavone in preserving bone health appears to be Genistein, which stimulates osteoblast and inhibits osteoclast function. Osteo protective effect of Formononetin on skeletal system results from the inhibition of osteoclastogenesis. Effects of Coumestrol on osteoblasts and osteoclasts are in increasing the bone density and preventing of bone resorption.

Bioactive flavonoids enhance bone formation and inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. 8-Prenylnaringenin promotes osteoblastic differentiation and inhibits bone resorption activity of osteoclasts by inducing ot their apoptosis.

Plant lignans have been shown to provide estrogenic support, antioxidant and anti-inflammatory activity. Stilbene antioxidant Resveratrol exerts potential to attenuate bone loss due to multiple actions on both osteoblasts and osteoclasts. Monoterpene components from essential oils protects from bone loss. Due to inhibitory of the osteoclast activity.

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References

Sanchez-Rodriguez MA, Ruiz-Ramos M, Correa-Munoz E, Mendoza-Nunez VM. Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskeletal Disord 2007;8(124):1-7.

Mao T, Kamakshi V. Bone grafts and bone substitutes. Int J Pharm Pharm Sci 2014;6(Suppl 2):88-91.

Cummings-Vaughn L, Grammack J. Falls, osteoporosis and hip fractures. Med Clin North Amer 2011;95(3):495-506.

Mazziotti G, Canalis E, Giustina A. Drug-induced osteoporosis: mechanisms and clinical Iimplications. Am J Med 2010;123(10):877-84.

Teucher B, Dainty JR, Spinks CA, Majsak-Newman G, Berry DJ, Hoogewerff JA, et al. Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. J Bone Miner Res 2008;23(9):1477-85.

Hallstrom H, Wolk A, Glynn A, Michaëlsson K. Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women. Osteoporos Int 2006;17(7):1055-64.

Mahmood M, Saleh A, Al-Alawi F, Ahmed F. Health effects of soda drinking in adolescent girls in the United Arab Emirates. J Crit Care 2008;23(3):434-40.

Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, et al. Benefits and risks of bisphosphonate therapy for osteoporosis. J Clin Endocrinol Metab 2012;97(7):2272-82.

Green J, Czanner G, Reeves G, Watson J, Wise L, Beral V. Oral bisphosphonates and risk of cancer of oesophagus, stomach, and colorectum: nested case-control study. BMJ 2010;341(1):4444.

Bowring CE, Francis RM. National osteoporosis society's position statement on hormone replacement therapy in the prevention and treatment of osteoporosis. Menopause Int 2011;17(2):63-5.

Sacco SM, Horcajada MN, Offord E. Phytonutrients for bone health during ageing. Br J Clin Pharmacol 2013;75(3):697-707.

Price CT, Langford JR, Liporace FA. Essential nutrients for bone health and a review of their availability in the average north american diet. Open Orthop J 2012;6(1):143-9.

Weaver CM, Alekel DL, Ward WE, Ronis MJ. Flavonoid intake and bone health. J Nutr Gerontol Geriatr 2012;31(3):239-53.

Putnam SE, Scutt AM, Bicknell K, Priestley CM, Williamson EM. Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health. Phytother Res 2007;21(2):99-112.

Kalita JC, Milligan SR. In vitro estrogenic potency of phytoestrogen-glycosides and some plant flavanoids. Ind J Sci Technol 2010;3(12):1142-7.

Cos P, De Bruyne T, Apers S, Berghe DV, Pieters L, Vlietinch AJ. Phytoestrogens: recent developments. Planta Med 2003;69(1):589-99.

Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women. Ann Intern Med 2007;146(1):839-47.

Nathiya S, Durga M, Devasena T. Quercetin, encapsulated Quercetin and its application-a review. Int J Pharm Pharm Sci 2014;6(10):20-6.

Kyung TW, Lee JE, Shin HH, Choi HS. Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-kB. Exp Mol Med 2008;40(1):52-8.

Ornstrup MJ, Harslof T, Kjaer TN, Langdahl BL, Pedersen SB. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab 2014;99(12):4720-9.

Habauzit V, Horcajada MN. Phenolic phytochemicals and bone. Phytochem Rev 2008;7(2):313-44.

Riggs BL. The mechanisms of estrogen regulation of bone resorption. J Clin Invest 2000;106(10):1203-4.

Krassas GE, Papadopoulou P. Oestrogen action on bone cells. J Musculoskeletal Neuronal Interact 2001;2(2):143-51.

Cederroth CR Nef S. Soy, phytoestrogens and metabolism: a review. Mol Cell Endocrinol 2009;304(1-2):30-42.

Song L, Liang X, Zhou Y. Estrogen-mimicking isoflavone genistein prevents bone loss in a rat model of obstructive sleep apnea-hypopnea syndrome. Int J Clin Exp Pathol 2014;7(4):1687-94.

Ward HA, Vogiatzoglou A, Luben RN, Mulligan A, Wareham NJ, Forouhi NG, et al. Association between dietary phyto-oestrogens and bone density in men and postmenopausal women. Br J Nutr 2011;106(7):1063-9.

Bitto A, Polito F, Squadrito F, Marini H, D'Anna R, Irrera N, et al. Genistein aglycone: a dual mode of action anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation. Curr Med Chem 2010;17(27):3007-18.

Poulsen RC, Kruger MC. Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action. Nutr Rev 2008;66(7):359-74.

Occhiuto F, Pasquale RD, Guglielmo G, Palumbo DR, Zangla G, Samperi S, et al. Effects of phytoestrogenic isoflavones from red clover (Trifolium pratense L.) on experimental osteoporosis. Phytother Res 2007;21(2):130-4.

Kenny AM, Mangano KM, Abourizk RH, Bruno RS, Anamani DE, Kleppinger A, et al. Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr 2009;90(1):234-42.

Ishimi Y. Soybean isoflavones in bone health. Forum Nutr 2009;61(1):104-16.

Sehmisch S, Erren M, Kolios L, Tezval M, Seidlova-Wuttke D, Wuttke W, et al. Effects of isoflavones Equol and Genistein on bone quality in a rat osteopenia model. Phytother Res 2010;(24, Suppl 2):S168-S74.

Ming LG, Chen KM, Xian CJ. Functions and action mechanisms of flavonoids Genistein and Icariin in regulating bone remodeling. J Cell Physiol 2013;228(3):513-21.

Hsieh TP, Sheu SY, Sun JS, Chen MH, Liu MH. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression. Phytomed 2010;17(6):414-23.

Yang L, Yu Z, Qu H, Li M. Comparative effects of Hispidulin, Genistein, and Icariin with ffects of Hispidulin, Genistein, and Icariin with estrogen on bone tissue in ovariectomized rats. Cell Biochem Biophys 2014;70(1):485-90.

Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2004;79(2):326-33.

Su SJ, Yeh YT, Su SH, Chang KL, Shyu HW, Chen KM, et al. Biochanin A promotes osteogenic but inhibits adipogenic differentiation: evidence with primary adipose-derived stem cells. Evidence-Based Complementary Altern Med 2013;2013(1);1-12.

Kuhnle GGC, Dell'Aquila C, Runswick SA, Bingham SA. Variability of phytoestrogen content in foods from different sources. Food Chem 2009;113(4):1184-7.

Mu H, Bai YH, Wang ST, Zhu ZM, Zhang YW. Research on antioxidant effects and estrogenic effect of Formononetin from Trifolium pratense (red clover). Phytomed 2009; 16(4):314-9.

Wu XT, Wang B, Wei JN. Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells. J Biomed Mater Res B Appl Biomater 2009;90(2):621-8.

Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-Equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial. Menopause 2011;18(5):563-74.

Shen CL, Chyu MC, Yeh JK, Zhang Y, Pence BC, Felton CK, et al. Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial. Osteoporosis Int 2012;23(5):1541-52.

Puel C, Mathey J, Agalias A, Kati-Coulibaly S, Mardon J, Obled C, et al. Dose-response study of effect of Oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr 2006;25(5):859-68.

Hooshmand S, Chai SC, Saadat RL, Payton ME, Brummel-Smith K, Arjmandi BH. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr 2011;106(6):923-30.

Possemiers S, Bolca S, Grootaert C, Heyerick A, Decroos K, Dhooge W, et al. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J Nutr 2006;136(7):1862-7.

Keiler AM, Zierau O, Kretzschmar G. Hop extracts and hop substances in treatment of menopausal complaints. Planta Med 2013;79(7):576-9.

Asthana S, Agarwa T, Khursheed A, Dutta D. Molecukar modeling and QSAR analysis to exploretherapeutic potentials of phytoestrogens in osteoporosis. Int J Pharm Pharm Sci 2014;6(3):239-43.

Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med 2013;79(7):538-53.

Luo D, Kang L, Ma Y, Chen H, Kuang H, Huang Q, et al. Effects and mechanisms of 8-Prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7. Food Sci Nutr 2014;2(4):341-50.

Lü X, Zhou Y, Chen KM, Zhao Z, Zhou J, Ma XN. Inhibitory effect of 8-Prenylnaringenin on osteoclastogensis of bone marrow cells and bone resorption activity. Yao Xue Xue Bao 2013;48(3):347-51.

Lv X, Chen KM, Ge BF, Ma HP, Song P, Cheng K. Comparative study on effect of 8-Prenlynaringenin and Narigenin on activity of osteoclasts cultured in vitro. Zhongguo Zhong Yao Za Zhi 2013;38(12):1992-6.

Ming LG, Lv X, Ma XN, Ge BF, Zhen P, Song P, et al. The prenyl group contributes to activities of phytoestrogen 8-Prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro. Endocrinol 2013;154(3):1202-14.

Peng S, Zhang G, Zhang BT, Guo B, He Y, Bakker AJ, et al. The beneficial effect of icaritin on osteoporotic bone is dependent on the treatment initiation timing in adult ovariectomized rats. Bone 2013 Jul; 55(1):230-40.

Cornish SM, Chilibeck PD, Paus-Jennsen L, Biem HJ, Khozani T, Senanayake V, et al. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metabol 2009;34(2):89-98.

Yin J, Tezuka Y, Subehan, Shi L, Nobukawa M, Nobukawa T, et al. In vivo anti-osteoporotic activity of Isotaxiresinol, a lignan from wood of Taxus yunnanensis. Phytomed 2006;13(1-2):37-42.

Mühlbauer RC, Lozano A, Palacio S, Reinli A, Felix R. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism. Bone 2003;32(4):372-80.

Published

10-04-2015

How to Cite

Pankova, S., and D. Tsvetkova. “ROLE OF PHYTOESTROGENS IN PREVENTION OF OSTEOPOROSIS”. International Journal of Current Pharmaceutical Research, vol. 7, no. 2, Apr. 2015, pp. 1-6, https://mail.innovareacademics.in/journals/index.php/ijcpr/article/view/5942.

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Section

Review Article(s)