DESIGN AND EVALUATION OF FORSKOLIN BUCCAL MUCOADHESIVE MICROSPHERES
Keywords:
Forskolin, Kondagogu gum, In vitro muco adhesion, Swelling indexAbstract
Objective: The objective of the present study was to develop buccal mucoadhesive microspheres of Forskolin (FSK) for hypertension.
Methods: The microspheres were prepared by orifice ionic gelation method using different ratios of Sodium alginate and Kondagogu gum. Fourier-transformed infrared (FTIR) spectroscopy study shows that drug and other excipients are compatible with each other. A 22 full factorial design was applied to optimize the formulation considering concentration of Sodium alginate and Kondagogu gum as independent variables; % swelling index and In vitro % muco adhesion as dependent variables.
Results: The prepared formulations were characterized for % yield, drug entrapment efficiency, scanning electron microscopy (SEM) and in vitro drug release. Microspheres prepared with the ratio of sodium alginate: kondagogu gum (1:1.5) showed swelling index 37±3 % and in vitro mucoadhesion 73±3%. SEM images confirmed that microspheres are a hollow spherical structure to a smooth surface morphology. The drug entrapment efficacy of all the formulations was in the range of 58.42±1.2–79.52±1.5 %.
Conclusion: The values of coefficient correlation (r) were calculated and were found to be zero order release from prepared formulation (K2).
Downloads
References
Macfarlane GT, Hay S, Macfarlane S, Gibson GR. Effect of different carbohydrates on growth, polysaccharidase and glycosidase production by Bacteroides ovatus, in batch and continuous culture. J Appl Bacteriol 1990;68(2):179-87.
Agarwal KC, Parks RE. Forskolin: a potential antimetastic agent. Int J Cancer 1983;32:801–4.
Mitra Jelvehgari, Hadi Valizadeh, Ramin Jalali Motlagh, Hassan Montazam. Formulation and physicochemical characterization of buccoadhesive microspheres containing diclofenac sodium. Adv Pharm Bull 2014;4(3):295-301.
Kim CK, Lee EJ. The controlled release of blue dextran from alginate beads. Int J Pharm 1992;79:11-9.
Hari PC, Chandy T, Sharma CP. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J Microencapsulation 1996;13:319-29.
Chowdary KPR, Rao YS. Design and in vitro and in vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: a technical note. AAPS Pharm Sci Tech 2003;4:39.
Shirur M, Chen J, Wei Z, Liu H, Bi D. Intranasal administration of melatonin starch microspheres. Int J Pharm Sci 2004;272:37-43.
Huang YC, Yen MK, Chiang CH. Formulation factors in preparing BTM-Chitosan microspheres by spray drying method. Int J Pharm 2000;242:239-42.
Wong CF, Yuen KH, Peh KK. An in-vitro method for buccal adhesion studies: importance of instrument variables. Int J Pharm 1999;180(1):47-57.
Shidhaye SS, Thakkar PV, Dand NM, Kadam VJ. Buccal drug delivery of pravastatin sodium. AAPS Pharm Sci Tech 2010;11(1):416-24.