DESIGN AND EVALUATION OF FORSKOLIN BUCCAL MUCOADHESIVE MICROSPHERES

Authors

  • Saritha T. Department of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana 500085, India, Department of Pharmaceutics, School of Pharmacy (Formerly Lalitha College of Pharmacy), Anurag Group of Institutions, Ghatkesar, Hyderabad 501301, Telangana, India,
  • Anna Balaji Trinity College of Pharmaceutical Sciences, Karimnagar, Telangana, India
  • Jaswanth A. Department of Pharmacology, Procadence Institute of Pharmaceutical Sciences, Medak, Telangana, India

Keywords:

Forskolin, Kondagogu gum, In vitro muco adhesion, Swelling index

Abstract

Objective: The objective of the present study was to develop buccal mucoadhesive microspheres of Forskolin (FSK) for hypertension.

Methods: The microspheres were prepared by orifice ionic gelation method using different ratios of Sodium alginate and Kondagogu gum. Fourier-transformed infrared (FTIR) spectroscopy study shows that drug and other excipients are compatible with each other. A 22 full factorial design was applied to optimize the formulation considering concentration of Sodium alginate and Kondagogu gum as independent variables; % swelling index and In vitro % muco adhesion as dependent variables.

Results: The prepared formulations were characterized for % yield, drug entrapment efficiency, scanning electron microscopy (SEM) and in vitro drug release. Microspheres prepared with the ratio of sodium alginate: kondagogu gum (1:1.5) showed swelling index 37±3 % and in vitro mucoadhesion 73±3%. SEM images confirmed that microspheres are a hollow spherical structure to a smooth surface morphology. The drug entrapment efficacy of all the formulations was in the range of 58.42±1.2–79.52±1.5 %.

Conclusion: The values of coefficient correlation (r) were calculated and were found to be zero order release from prepared formulation (K2).

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Published

15-07-2015

How to Cite

T., S., A. Balaji, and J. A. “DESIGN AND EVALUATION OF FORSKOLIN BUCCAL MUCOADHESIVE MICROSPHERES”. International Journal of Current Pharmaceutical Research, vol. 7, no. 3, July 2015, pp. 17-21, https://mail.innovareacademics.in/journals/index.php/ijcpr/article/view/7911.

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Original Article(s)