SPECTROPHOTOMETRIC DETERMINATION OF MEPHEDRONE IN A BULK FORM

Authors

  • Vaishali Parastekar V. E. S College of Arts, Science and Commerce, Sindhi Society, Chembur, Mumbai 400071
  • Vasant Barhate V. E. S College of Arts, Science and Commerce, Sindhi Society, Chembur, Mumbai 400071

Keywords:

Mephedrone, Spectophotomerty, Oxidation, Potassium permanganate, 1, 10-phenanthroline

Abstract

Objective: Two simple and sensitive Spectrophotometric methods are developed for estimation of Mephedrone.

Methods: The first method is based on oxidation of the drug with alkaline Potassium Permanganate at room temperature (25± °c). The increase in absorbance of colored Manganate ions was measured at 610 nm. The second method is based on the oxidation of the drug with 1, 10–phenanthroline producing red colored chromogen which is measured at 510 nm.

Results: All parameters affecting the developments of the color were investigated and the conditions were optimized. Under the optimum condition used, Beer's law was obeyed in the concentration range 40-160 µg/ml and 80-220 µg/ml for method A and B respectively. Molar absorptivity was found to be 4.60×102 L. mole-1 cm-1and 3.89×102 L. mole-1 cm-1 respectively.

Conclusion: The proposed methods are well suited for determination of Mephedrone in bulk samples.

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References

Adam Winstock, Luke Mitcheson, John Ramsey Susannah Davies, Malgorzata Puchnavewicz, John Marsden. Mephedrone use, subjective effects and health risks; Society for the study. Addiction 2011;106(11):1991-6.

C Rambabu, S Venkata Rao, G Ramu, A Biksham Babu. Quantitative analysis of Mephedrone in bulk and pharmaceutical formulations by reverse phase high performance liquid chromatography. Rasayan J Chem 2010;3(4):796-9.

Eman Y Santali, Anna-Karnia Cadogan, Niamh Nic Daeid, Kathleen A. Sarage, Oliver B. Sulclifee. Synthesis, full chemical characterization and development of validate d methods for the quantitation of (±)-4 methylmethacathinone (Mephedrone). J Pharm Biomed Anal 2011;56(2):246-55.

Peter Jankovics, Andras Varadi, Laszio Tolayesi, Szilvia Lohner Julia Nemeth Palotas, Hilda Koszegi szalai. Identification & characterization of the new designer drug 4’-methylmethacathinone (4-MEC) and elaboration of a novel liq chromatography-tandem mass spectroscopy [LC-MS]. Forensic Sci Int 210;(1-3):213-20.

Emmislivka, Characterization of (MDPV) & Mephedrone in Legal High†products by chemical colour test, microcrystalline tests with confirmation by LC-MS, The Center For Forensic Science Research & Education, Willow curve, PA. ARCADIA university; 2011.

Syeda A Shah, James Barker, Andrea Petroczi, Paul Cross, Roland Archer. Quantitative analysis of Mephedrone using Liquid chromatography tandem mass spectroscopy; Application to human hair. J Pharm Biomed Anal 2012;6:64-9.

El Shamaileh Majed, Gonzalez-Rodriquez, Jose, Baron, Mark, Croxton, et al. A rapid HPLC-DAD method for the simultaneous analysis of mephedrone & methcathinone after liquid-liquid extraction from serum & whole blood matrices; IALM 2012, 22nd congress of the international Academy of legal Medicine, Turkey; 2012.

Aftab Aslam Parwaz Khan, Ayaz Mohd, Shaista Bano, KS Siddiqi, Abdullah Mohammed Asiri. Spectrophotometric methods for the determination of Ampicillin by KMnO4 and 1-chloro-2, 4-dinitrobenzene in pharmaceuticals. Arabian J Chem 2015;8(2):255-63.

Kalsang Tharpa, Kanakapura Basavaiah, Nagaraju Rajendraprasad, Kanakpura Basavaiah Vinay, Salmara Ganeshbhat Hiriyanna. Sensitive spectrophotometric assay of simvastin in pharmaceuticals using permanganate. Braz J Pharm Sci 2010;46:1.

Mohamaed, El-Ghaffar, Dina El Sherbiny, Dalia El-wasseef, Saadia El-Ashry. Spectrophotometric methods for determination of Ritodrine in bulk and in pharmaceutical dosage form. J Food Anal 2008;16(2):26-35.

Biksham Babu, G Ramu, S Venkata Rao, T Neeharika, C Rambabu. Spectrophotometric determination of an antiretroviral drug stavudine in bulk and pharmaceutical formulations: A. Rasayan J Chem 2011;4(2):33.

Published

15-07-2015

How to Cite

Parastekar, V., and V. Barhate. “SPECTROPHOTOMETRIC DETERMINATION OF MEPHEDRONE IN A BULK FORM”. International Journal of Current Pharmaceutical Research, vol. 7, no. 3, July 2015, pp. 51-55, https://mail.innovareacademics.in/journals/index.php/ijcpr/article/view/7920.

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