ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL OF QUCERTIN

Authors

  • Muthukala B. Department of Advanced Zoology and Biotechnology, Presidency College, Chennai 600005
  • Sivakumari K. Department of Advanced Zoology and Biotechnology, Presidency College, Chennai 600005
  • Ashok K. Department of Advanced Zoology and Biotechnology, Presidency College, Chennai 600005

Keywords:

Qucertin, Antioxidant, Anti-inflammatory, Hemoprotective

Abstract

Objective: In the present study the antioxidant potential and anti-inflammatory effect of qucertin compound was assessed.

Methods: The antioxidant potential of the drug was determined by ORAC assay and DPPH assay. Likewise for anti-inflammatory studies, RBC's were collected from healthy volunteers and the hemo protective activity of the drug was carried out at various concentrations.

Results: The results showed that qucertin has a positive effect on both the parameters. The probable reasons governing the facts are discussed in the light of previous literature.

Conclusion: The results show that qucertin seems to be a good replacement for chemical therapeutic drugs as it has antioxidative and anti-inflammatory properties.

Downloads

Download data is not yet available.

References

Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83–98.

Middleton EJ. Effect of plant flavonoids on immune and inflammatory cell functions. Adv Exp Med Biol 1998;439:175-82.

De Groot H, Rauen U. Tissue injury by reactive oxygen species and the protective effects of flavonoids. Fundam Clin Pharmacol 1998;12:249-55.

Huang D, Ou B, Hampsch-Woodill M, Flanagan J, Prior R. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 2002;50:4437-44.

Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agric Food Chem 2005;53:1841-56.

Gandhidasan R, Thamaraichelvan A, Baburaj S. Anti-inflammatory action of Lannae coromandelica by HRBC membrane stabilization. Fitoterapia 1999;62:81-3.

Meena MC, Patini V. Isolation and identification of flavonoid Qucertin†from Citrullus colocynthis (Linn.) Schrad. Asian J Exp Sci 2008;22(1):137-42.

Harborne JB. Plant phenolics. In: secondary plant products (Eds) Bell EA, Charlewood BV, Springer Verlag Berlin; 1981. p. 320.

Casteel HW, Wender SM. Identification of flavonoid compounds, Rf values and colour tests. Anal Chem 1953;25l:508.

Smith EB. In: Prospective in phytochemistry (Eds) Harborne JB, Swain T. Academic Press; London: 1969.

Harsh ML, Nag TN, Jain S. Arid zone plants of Rajasthan a source of antimicrobials. Comp Physiol Ecol 1983;8:129-31.

Ulubelen A, Mabry JJ, Dellamonicas G, Chopin J. Flavonoids of Passiflora plamer. J Nat Prod 1984;47:384-5.

Goswami A, Reddi A. Antimicrobial activity of flavonoids of medicinally important plant Cassia angustifolia in vivo and in vitro. J Phytol Res 2004;17:179-81.

Saxena S, Sharma R, Rajore S, Batra A. Isolation and identification of flavonoid "Vitexin" from Jatropha curcas L. J Plant Sci Res 2005;21:116-7.

Joshi RS. Biosynthesis of primary and secondary products from in vivo and in vitro tissue cultures of some medicinal plants. Ph. D. Thesis, University of Rajasthan, Jaipur, India; 1985.

Jain R, Patni V, Arora DK. Isolation and identification of flavonoid "quercetin" from Acacia catechu (L. f.) Willd-A Katha yielding plant. J Phytol Res 2007;20:43-5.

Ferrali C, Signorini B, Caciotti. Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity. FEBS Lett 1997;416:123–9.

Published

15-07-2015

How to Cite

B., M., S. K., and A. K. “ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL OF QUCERTIN”. International Journal of Current Pharmaceutical Research, vol. 7, no. 3, July 2015, pp. 58-59, https://mail.innovareacademics.in/journals/index.php/ijcpr/article/view/7923.

Issue

Section

Original Article(s)