A CRITICAL INSIGHT INTO SHIKIMATE KINASE PATHWAY
Keywords:
Tuberculosis, MDR-TB, Shikimate Kinase, Shikimate pathwayAbstract
Objective: Tuberculosis is the most infectious disease that appears to be dreadful even in the presence of anti tubercular drugs. The problem of MDR-TB is growing at an alarming rate and the prevalence of the disease cause devastation to the molecular level. We hereby carry out a review of shikimate pathway used for tuberculosis management. Based on the available evidence on its vital roles, we highlight ways in which their therapeutic potential can be properly harnessed for possible integration into the country's healthcare system.
Methods: Information was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 20115 for publications on shikimate pathways and their therapeutic targets for Multi Drug Resistance Tuberculosis (MDR-TB).
Results: Numerous factors have been reported to be the causative agent in the progression of the disease. Apart from this, a number of transcription factors is also been involved in the down regulation of the modulatory pathology. The emergence of MDR-TB washes out the treatment and control of Tuberculosis at an extremely difficult stage. Epidemilogical data revels that Tuberculosis kill approx. 3 million people in a year. Shikimate Kinase and other agents can be involved therapeutic target and evaluation of new pathways. Emphasis need to be urgently given for the diagnosis and treatment of the TB in the society effectively.
Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of Shikimate Kinase Pathway used in MDR-TB management so as to ensure a more rational use. Shikimate Kinase is one of the main enzymes involved in Shikimate pathway that has emerged as a vital target in many of the morbidity.
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