AN EXHAUSTIVE REVIEW ON EMERGING DRUG TARGETS OF TUBERCULOSIS WITH SPECIAL EMPHASIS ON CELL WALL SYNTHESIS

SNEHAL R THAKAR; DEEPALI A BANSODE

doi:10.22159/ijls.2021.v9i5.42000

Authors

SNEHAL R THAKAR Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
DEEPALI A BANSODE Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.

DOI:

https://doi.org/10.22159/ijls.2021.v9i5.42000

Keywords:

Cell wall synthesis, Enzymatic pathways, Mycolic acid, Tuberculosis

Abstract

Tuberculosis (TB) is one of the top 10 causes of mortality and morbidity. Worldwide, yet, it has been over 60 years since a novel drug was introduced in market to treat the disease exclusively. Increased number of drug resistant TB cases has prompted the search for novel potent anti-TB drug. Mycobacterial cell wall has unique structure which provides integrity to the cell. The future development of new potent anti-TB drug targets is associated with the synthesis of various cell wall constituents; the structural and genetic information about mycobacterial cell wall envelope is now available. In the present review, we have focused on prospective drug targets that can be optimum triumph for successful drug candidate.

Author Biography

DEEPALI A BANSODE, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.

BVDU PCP is a renowned institute which had ranked 4th in NIRF amongst the Pharmacy institiutions in India. Reserach in our institute is the basis of our ranking.

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