THE CORRELATION OF MATRIX METALLOPROTEINASE-9 WITH STROKE AND PREVALENCE, RISK FACTORS, AND KNOWLEDGE OF STROKE AMONG PALESTINIANS

ROZAN ATTILI; HATEM A HEJAZ

doi:10.22159/ijms.2020.v8i6.39593

Authors

ROZAN ATTILI Department of Medical Sciences, College of Pharmacy and Medical Sciences, Hebron University, P. O. Box 40; Hebron, Palestine.
HATEM A HEJAZ Department of Medical Sciences, College of Pharmacy and Medical Sciences, Hebron University, P. O. Box 40; Hebron, Palestine.

DOI:

https://doi.org/10.22159/ijms.2020.v8i6.39593

Keywords:

Matrix metalloproteinase-9, Risk-factors, Stroke, MMP-9, Ischemic stroke, Knowledge, Prevalence

Abstract

Objectives: The research study aims to estimate the prevalence of the stroke, to evaluate the stroke associated risk factors, and to determine the factors and symptoms associated with the knowledge of the stroke among the Palestinian population. Furthermore, to find the association between matrix metalloproteinase-9 (MMP-9) levels and the stroke, the concentration of MMP-9 in the serum of stroke patients was measured.

Methods: The research study includes a cross-sectional survey that was conducted. The serum MMP-9 levels were also measured in 11 stroke patients using an ELISA reader. Statistical analysis was performed by GraphPad Prism version 8. Sociodemographic characteristics of stroke patients associated with stroke among the Palestinian population were also obtained and analyzed.

Results: The higher incidence of the stroke was in the patient’s ages between 51 and 60 years old, with 30 patients (46%) of the total stroke patients. The majority of the stroke patients 40 (60.6%) were having enough income. Most of the stroke patients (29, 43.9%) were none educated. The majority of the stroke patients 48 (72.2%) had a family member/s who has been diagnosed with a stroke. Most of the stroke patients 60 (90.9%) have sudden numbness, weakness in the face, arms, and legs. All the samples analyzed showed a marked increase in MMP-9 concentration.

Conclusions: The prevalence of stroke and the high risk of stroke were high among adults aged ≥51 years in Palestine. Hypertension was the highest risk factor for stroke. The serum MMP-9 could be an important prognostic factor for the stroke.

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